2-methylbutanedioic acid, 1-(2,5-dioxo-1-pyrrolidinyl)4-methyl ester | 343967-88-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methylbutanedioic acid, 1-(2,5-dioxo-1-pyrrolidinyl)4-methyl ester
• 英文别名: 1-O-(2,5-dioxopyrrolidin-1-yl) 4-O-methyl 2-methylbutanedioate
• CAS: 343967-88-4
• 化学式: C₁₀H₁₃NO₆
• 分子量: 243.216
• InChiKey: VANTZWRXYQLQLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  90
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-methylbutanedioic acid, 1-(2,5-dioxo-1-pyrrolidinyl)4-methyl ester 、 (8S)-1,4-二氧杂-7-氮杂螺[4.4]壬烷-8-羧酸 生成 (8S)-7-[(2R)-4-methoxy-2-methyl-4-oxobutanoyl]-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid
  参考文献：
  名称：

  ONDETTI, M. A.;CONDON, M. E.

  摘要：

  DOI：
• 作为产物：
  描述：

  4-methoxy-2-methyl-4-oxobutanoic acid 、 N-羟基丁二酰亚胺 生成 2-methylbutanedioic acid, 1-(2,5-dioxo-1-pyrrolidinyl)4-methyl ester
  参考文献：
  名称：

  ONDETTI, M. A.;CONDON, M. E.

  摘要：

  DOI：

文献信息

• Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04311705A1

  公开（公告）日：1982-01-19

  Compounds, compositions and method of alleviating hypertension using a compound of the formula ##STR1## wherein R is hydrogen or lower alkyl; R.sub.1 is hydrogen, lower alkyl or phenyl-lower alkyl; R.sub.2 is hydrogen, lower alkyl or phenyl lower alkyl or halo substituted lower alkyl; R.sub.3 is hydroxy, --NHOH or lower alkoxy; Pr-COOR is a substituted proline of the structures ##STR2## R.sub.4 is halogen, keto, azido, cycloalkyl, phenyl, substituted phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, ##STR3## or Y--R.sub.6 ; R.sub.5 is hydrogen or lower alkyl; Y is oxygen or sulfur; R.sub.6 is lower alkyl, phenyl, substituted phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, 1- or 2-naphthyl, substituted 1- or 2- naphthyl, biphenyl, or substituted biphenyl; R.sub.7 is halogen or --Y--R.sub.8 ; R.sub.8 is lower alkyl, phenyl, phenyl-lower alkyl substituted phenyl-lower alkyl, biphenyl, napthyl, or the R.sub.8 groups join to complete an unsubstituted 5- or 6-membered ring or such ring wherein one or more carbon atoms are substituted by a lower alkyl or di(lower alkyl) group; R.sub.9 is keto, phenyl, 2- or 4-hydroxyphenyl; n is 0 or 1; and salts thereof.

  这是一段关于使用某化合物缓解高血压的方法、化合物和组合物的描述。
• ONDETTI, M. A.;CONDON, M. E.
  作者：ONDETTI, M. A.、CONDON, M. E.

  DOI：——

  日期：——
• Amylin Peptides and Derivatives and Uses Thereof
  申请人：Sun Chengzao

  公开号：US20140221287A1

  公开（公告）日：2014-08-07

  There are provided polypeptide conjugates having enhanced duration of biological activity, and methods of use thereof. The polypeptide conjugates include duration enhancing moieties, including water soluble polymers, bound to the polypeptide components of defined sequence. Methods of use are provided for treatment of metabolic disorders. Methods of use are provided for treatment of an eating disorder, insulin resistance, obesity, overweight, abnormal postprandial hyperglycemia, Type I diabetes, Type II diabetes, gestational diabetes, metabolic syndrome, dumping syndrome, hypertension, dyslipidemia, cardiovascular disease, hyper lipidemia, sleep apnea, cancer, pulmonary hypertension, cholescystitis, osteoarthritis, or short bowel syndrome.