2-苄基-5-氨基甲基吲哚 | 773884-24-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 2-苄基-5-氨基甲基吲哚
• 中文别名: 2-苄基-5-氨甲基吲哚
• 英文名称: (2-benzyl-1H-indol-5-yl)methylamine
• 英文别名: (2-benzyl-1H-indol-5-yl)methanamine
• CAS: 773884-24-5
• 化学式: C₁₆H₁₆N₂
• 分子量: 236.316
• InChiKey: NOGIEXNFAHCQBM-UHFFFAOYSA-N

物化性质

• 沸点：
  445.7±35.0 °C(Predicted)
• 密度：
  1.174±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  41.8
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 海关编码：
  2933990090

文献信息

• Bicyclic compounds as NR2B receptor antagonists
  申请人：——

  公开号：US20040204409A1

  公开（公告）日：2004-10-14

  This invention provides a compound of the formula (I): 1 wherein R 1 and R 2 independently represent a hydrogen atom or the like; X represents a covalent bond or the like: A represents a bicyclic, aromatic, saturated or partially unsaturated heterocyclic or carbocyclic group having from 8 to 12 ring atoms; or the like: B represents a phenyl group or a heteroaryl group having from 5 to 6 ring atoms or the like: These compounds are useful for the treatment of disease conditions caused by overactivation of NMDA NR2B receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.

  这项发明提供了一个化合物，其化学式为(I):其中R1和R2分别表示氢原子或类似物；X表示共价键或类似物；A表示具有8至12个环原子的双环、芳香、饱和或部分不饱和的杂环或碳环基团；或类似物；B表示具有5至6个环原子的苯基或杂环基团；或类似物。这些化合物对于治疗由NMDA NR2B受体过度活化引起的疾病情况，如疼痛等在哺乳动物中具有用途。这项发明还提供了包含上述化合物的药物组合物。
• EP1615636A1
  申请人：——

  公开号：EP1615636A1

  公开（公告）日：2006-01-18
• [EN] BICYCLIC COMPOUNDS AS NR2B RECEPTOR ANTAGONISTS<br/>[FR] COMPOSES BICYCLIQUES COMME ANTAGONISTES DU RECEPTEUR NR2B
  申请人：PFIZER JAPAN INC

  公开号：WO2004089366A1

  公开（公告）日：2004-10-21

  This invention provides a compound of the formula (I) wherein R1 and R2 independently represent a hydrogen atom or the like; X represents a covalent bond or the like: A represents a bicyclic, aromatic, saturated or partially unsaturated heterocyclic or carbocyclic group having from 8 to 12 ring atoms; or the like: B represents a phenyl group or a heteroaryl group having from 5 to 6 ring atoms or the like: These compounds are useful for the treatment of disease conditions caused by overactivation of NMDA NR2B receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.