N,N'-dimethyl-5-nitro-pyrimidine-4,6-diamine | 6964-30-3

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: N,N'-dimethyl-5-nitro-pyrimidine-4,6-diamine
• 英文别名: N⁴,N⁶-dimethyl-5-nitro-pyrimidine-4,6-diyldiamine；N⁴,N⁶-Dimethyl-5-nitro-pyrimidin-4,6-diyldiamin；N4,N6-dimethyl-5-nitropyrimidine-4,6-diamine；4-N,6-N-dimethyl-5-nitropyrimidine-4,6-diamine
• CAS: 6964-30-3
• 化学式: C₆H₉N₅O₂
• 分子量: 183.17
• InChiKey: UXSRDBONEIZHCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  95.7
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  草酰氯 、 N,N'-dimethyl-5-nitro-pyrimidine-4,6-diamine 在 苯 作用下， 生成 4,6,4',6'-tetrakis-methylamino-5,5'-dinitro-1,1'-oxalyl-bis-pyrimidinium; dichloride
  参考文献：
  名称：

  643.蝶啶衍生物。第三部分 双二氢嘌呤基

  摘要：

  DOI：

  10.1039/jr9560003311
• 作为产物：
  描述：

  4,6-二氯-5-硝基嘧啶 、 甲胺 在 水 作用下， 生成 N,N'-dimethyl-5-nitro-pyrimidine-4,6-diamine
  参考文献：
  名称：

  Potential Purine Antagonists. IV. Synthesis of Some 9-Methyl-6-substituted-purines¹

  摘要：

  DOI：

  10.1021/ja01559a069

文献信息

• Synthesis and thermal transformations of 5-nitropyrimidin-4-yl dialkyldithiocarbamates
  作者：O. B. Ryabova、V. A. Makarov、V. V. Chernyshev、V. G. Granik

  DOI：10.1023/b:rucb.0000037858.17011.fb

  日期：2004.4

  heating, 5-nitropyrimidin-4-yl dialkyldithiocarbamates undergo two types of transformations. One type of these transformations involves intramolecular ipso-substitution of the nitro group to form bis(4-dialkylcarbamoylthiopyrimidin-5-yl) disulfides, whereas another type of transformations involves elimination of carbon disulfide to give 4,6-diamino-5-nitropyrimidine derivatives. The reaction pathway is controlled

  加热时，5-硝基嘧啶-4-基二烷基二硫代氨基甲酸酯经历两种类型的转化。这些转化的一种类型涉及硝基的分子内同位取代以形成双（4-二烷基氨基甲酰基硫代嘧啶-5-基）二硫化物，而另一种类型的转化涉及消除二硫化碳以得到 4,6-二氨基-5-硝基嘧啶衍生物. 反应途径受嘧啶环 6 位取代基的空间效应控制。
• Potential Purine Antagonists. IV. Synthesis of Some 9-Methyl-6-substituted-purines¹
  作者：Roland K. Robins、Hsi Hu Lin

  DOI：10.1021/ja01559a069

  日期：1957.1
• 643. Pteridine derivatives. Part III. Bisdihydropurinyls
  作者：W. E. Fidler、H. C. S. Wood

  DOI：10.1039/jr9560003311

  日期：——
• Conditioning of Skeletal Muscles in Adult and Old Mice for Protection From Contraction-Induced Injury
  作者：S. V. Brooks、J. A. Opiteck、J. A. Faulkner

  DOI：10.1093/gerona/56.4.b163

  日期：2001.4.1

  The purpose of this study was to design a conditioning program that protected muscles in both adult and old mice from a protocol of contractions that previously caused a significant number of damaged fibers and a deficit in force, Hind-limb dorsiflexor muscles of adult (7 months) and old (22 months) female B6D2F1 mice were exposed once a week to a protocol of repeated forced stretches while maximally activated in vivo. By week 4, muscles of adult, but not old, mice showed no force deficit. Conditioning was continued for 6 weeks, when both age groups showed no force deficit for two consecutive weeks. Three days after the sixth contraction protocol, when morphological damage and force deficits are most severe, the numbers of damaged fibers in muscles of adult and old mice were not different from those in uninjured control muscles and the force deficits were reduced dramatically compared with unconditioned muscles. We conclude that muscles of both adult and old mice conditioned successfully, but muscles of old mice conditioned more slowly than those of adult mice.