3-dimethylamino-2-phenylpropenal | 67382-50-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-dimethylamino-2-phenylpropenal
• 英文别名: 3-(dimethylamino)-2-phenyl-2-propenal；(E)-3-(Dimethylamino)-2-phenylacrylaldehyde；(E)-3-(dimethylamino)-2-phenylprop-2-enal
• CAS: 67382-50-7
• 化学式: C₁₁H₁₃NO
• 分子量: 175.23
• InChiKey: ABQPNXRKOONAJA-FLIBITNWSA-N

物化性质

• 沸点：
  394.5±31.0 °C(Predicted)
• 密度：
  1.022±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-dimethylamino-2-phenylpropenal 、 氰乙酰胺 在 sodium methylate 、 溶剂黄146 作用下， 以 甲醇 、 水 为溶剂， 生成 1,2-二氢-2-氧代-5-苯基-3-吡啶甲腈
  参考文献：
  名称：

  Substituted 6-phenyl-5,6,7,8-tetrahydro-1,2,4-triazolo-[4,3-a]pyridines

  摘要：

  本披露描述了新型的取代的6-苯基-5,6,7,8-四氢-1,2,4-三唑并[4,3-a]吡啶及其作为治疗焦虑的药物的用途。

  公开号：

  US04244953A1
• 作为产物：
  描述：

  N,N-二甲基甲酰胺 、 1,1-二甲氧基-2-苯基乙烷 在 三氯氧磷 作用下， 生成 3-dimethylamino-2-phenylpropenal
  参考文献：
  名称：

  Barton, Derek H. R.; Dressaire, Gilles; Willis, Brian J., Journal of the Chemical Society. Perkin transactions I, 1982, p. 665 - 670

  摘要：

  DOI：

文献信息

• Substituted 6-phenyl-1,2,4-triazolo[4,3-a]pyridines
  申请人：American Cyanamid Company

  公开号：US04209626A1

  公开（公告）日：1980-06-24

  This disclosure describes novel 6-(substituted-phenyl)-1,2,4-triazolo[4,3-a]pyridines useful as hypotensive agents.

  本公开说明了一种新型6-(取代苯基)-1,2,4-三唑并[4,3-a]吡啶，可用作降压药剂。
• Substituted 3-alkyl-6-phenyl-1,2,4-triazolo-[4,3-a]pyridines
  申请人：American Cyanamid Company

  公开号：US04242515A1

  公开（公告）日：1980-12-30

  This disclosure describes novel 3-alkyl-6-(substituted-phenyl)-1,2,4-triazolo[4,3-a]pyridines useful as anxiolytic agents.

  这份披露描述了作为抗焦虑药物有用的新型3-烷基-6-(取代苯基)-1,2,4-三唑并[4,3-a]吡啶。
• Substituted 3-alkyl-6-phenyl-1,2,4-triazolo(4,3-a)pyridines, processes for their preparation and pharmaceutical compositions containing them
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0017438A1

  公开（公告）日：1980-10-15

  There are provided novel 3-alkyl-6-(substituted-phenyl)-1,2,4-triazolo[4,3-a]pyridines useful as anxiolytic agents, processes for their preparation and pharmaceutical compositions containing them. The compounds have the formula: wherein R, is hydrogen, alkyl (C1-C4), alkoxy (C,-C4), fluoro, chloro, bromo, trifluoromethyl, cyano, carboxy, alkoxycarbonyl (C2-C5), carboxamido, nitro, amino, acylamino (C1-C4), monoalkylamino (C1-C4) or dialkylamino wherein each alkyl group has up to 4 carbon atoms and R2 is alkyl (C1-C3); or a pharmacologically acceptable acid-addition salt thereof.

  本发明提供了可用作抗焦虑剂的新型 3-烷基-6-（取代苯基）-1,2,4-三唑并[4,3-a]吡啶、其制备工艺以及含有这些化合物的药物组合物。这些化合物的化学式如下 其中 R，是氢、烷基（C1-C4）、烷氧基（C,-C4）、氟、氯、溴、三氟甲基、氰基、羧基、烷氧羰基（C2-C5）、羧酰胺基、硝基、氨基、酰氨基（C1-C4）、单烷基氨基（C1-C4）或二烷基氨基，其中每个烷基最多有 4 个碳原子，R2 是烷基（C1-C3）；或其药理学上可接受的酸加成盐。
• Spiro[2,2,6,6-tetramethyl-piperidine-4,2'-(1',3'-dioxo(ol)an]-derivatives and stabilizers for synthetic polymers
  申请人：ADEKA ARGUS CHEMICAL CO., Ltd.

  公开号：EP0042622A1

  公开（公告）日：1981-12-30

  2,2,6,6-Tetramethyl-4-piperidyl spiro aliphatic ethers are provided, useful as stabilizers for organic polymeric materials and having the general formula: wherein: Y is X is selected from the group consisting of alkylene having from one to about eighteen carbon atoms; cycloalkylene having from three to about eight carbon atoms; arvlene having from about six to about eighteen carbon atoms; polyacyl wherein n1 is a number from 2 to 4; polycarbamoyl vherein n2 is a number from 2 to 4; and di- and trivalent oxyacid groups; R1 is selected from the group consisting of hydrogen, R2 is selected from the group consistinq of hvdroaen and R3 is selected from the group consisting of alkyl having from one to about eighteen carbon atoms; cycloalkyl having from three to about eight carbon atoms; aryl having from about six to about eighteen carbon atoms; and -X-O-R1; R4 is selected from the group consisting of hydrogen; aliphatic having from one to about eighteen carbon atoms; cycloaliphatic having from three to about eight carbon atoms; heterocyclic having from six to about eighteen carbon atoms; and aromatic having from six to about eighteen carbon atoms; R5 is selected from the group consisting of aliphatic having from one to about eighteen carbon atoms; cycloaliphatic having from three to about eight carbon atoms; heterocyclic having from six to about eighteen carbon atoms; and aromatic having from six to about eighteen carbon atoms; and monovalent oxyacid groups; R7 is selected from the group consisting of the residues of monohydric alcohols having from one to about eighteen carbon atoms and phenols having from six to about fifty carbon atoms; Rs is selected from the group consisting of and Rs is selected from the group consisting of aliphatic R5 and cycloaliphatic R5; and -CH2OR10; R10 is selected from the group consisting of hydrogen, R11 is selected from the group consisting of alkylene and oxyalkylene having from two to about ten carbon atoms and from zero to about five oxyether groups; cycloalkylene having from three to about eight carbon atoms; and arylene having from six to about fifty carbon atoms; and isocyanurate; R12 is the residue of mono-, di-, tri- or tetracarboxylic acid; R,3 is selected from the group consisting of hydrogen, R5, and -O-R5; m is a number from zero to 10; n is a number from zero to 4; p is zero or 1; q is a number from zero to 3; and r is zero or 1.

  本发明提供了 2,2,6,6-四甲基-4-哌啶基脂肪族螺醚，可用作有机聚合物材料的稳定剂，其通式为 其中Y 是 X 选自具有 1 至约 18 个碳原子的亚烷基；具有 3 至约 8 个碳原子的环烷基；具有约 6 至约 18 个碳原子的芳基；聚芳基 其中 n1 是 2 至 4 的数字；聚氨基甲酰基 其中 n2 的数值为 2 至 4； R1选自由氢组成的组、 R2 选自由氢和三价氧酸基团组成的组。 R3 选自由 1 至约 18 个碳原子的烷基、3 至约 8 个碳原子的环烷基、约 6 至约 18 个碳原子的芳基和-X-O-R1 所组成的组； R4 选自由氢、1 至 18 个碳原子的脂肪族、3 至 8 个碳原子的环脂族、6 至 18 个碳原子的杂环族和 6 至 18 个碳原子的芳香族组成的组； R5 选自由 1 至约 18 个碳原子的脂肪族、3 至约 8 个碳原子的环脂族、6 至约 18 个碳原子的杂环族和 6 至约 18 个碳原子的芳香族组成的组； 以及单价氧酸基团； R7 选自具有 1 至约 18 个碳原子的一元醇残基和具有 6 至约 50 个碳原子的苯酚残基组成的组； Rs 选自由下列物质组成的组 和 Rs 选自由脂肪族 R5 和环脂族 R5 组成的组；以及 -CH2OR10； R10 选自由氢组成的组、 R11 选自具有 2 至约 10 个碳原子和 0 至约 5 个氧醚基团的亚烷基和氧烷基、具有 3 至约 8 个碳原子的环烷基和具有 6 至约 50 个碳原子的芳基组成的组；以及异氰尿酸酯； R12 是一元、二元、三元或四元羧酸的残基； R,3选自由氢、R5和-O-R5组成的组； m 是零至 10 的数字； n 是零到 4 之间的数值 p 为零或 1 q 是零至 3 的数字；以及 r 为零或 1。
• 3-Amino-5-(substituted)-2 (1H) pyridinones and 3-cyano compounds useful as cardiotonics and preparation thereof
  申请人：STERLING DRUG INC.

  公开号：EP0061774A2

  公开（公告）日：1982-10-06

  1-R1-3-amino-5-(3-R'-4-R"-phenyl)-6-R-2(1H)-pyridi- nones or salts thereof, which are useful as cardiotonics, where R, is hydrogen, lower-alkyl, or lower-hydroxyalkyl, R is hydrogen or lower-alkyl, and, R' and R" are each hydrogen, hydroxy or amino at least one of R' or R" being other than hydrogen, are prepared by reacting the corresponding 3-carbamyl compound with a reagent capable of converting carbamyl to amino or by first reacting the corresponding 3-carbamyl compound where R' and R" are each hydrogen, nitro or lower-alkoxy with a reagent capable of converting carbamyl to amino and then reacting the resulting 3-amino compound where R' and/or R" are/is lower-alkoxy and/or nitro with a reagent capable of converting lower-alkoxy to hydroxy and/or with a reagent capable of converting nitro to amino. Preparation of the corresponding 3-carbamyl and 3-cyano compounds are described. The invention also concerns the 3- and/or 4-methoxy intermediates and certain novel 3-cyano analogs. Cyano compounds are also useful as cardiotonics.

  1-R1-3-氨基-5-(3-R'-4-R"-苯基)-6-R-2(1H)-吡啶-壬烷或其盐，可用作强心剂，其中 R 是氢、低级烷基或低级羟基烷基，R 是氢或低级烷基，R'和 R "各自是氢、羟基或氨基，R'或 R "中至少有一个不是氢、将相应的 3-氨基甲酰基化合物与能将氨基甲酰基转化为氨基的试剂反应，或先将 R' 和 R "均为氢、硝基或低级烷氧基的相应 3-氨基甲酰基化合物与能将氨基甲酰基转化为氨基的试剂反应，然后将所得 R' 和/或 R "为/或低级烷氧基和/或硝基的 3-氨基化合物与能将低级烷氧基转化为羟基的试剂和/或能将硝基转化为氨基的试剂反应，制备 3-氨基甲酰基化合物。本发明描述了相应的 3-氨基甲酰基和 3-氰基化合物的制备方法。本发明还涉及 3-和/或 4-甲氧基中间体和某些新型 3-氰基类似物。氰基化合物还可用作强心剂。