1,2-bis-phenylacetoxy-ethane | 70632-18-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2-bis-phenylacetoxy-ethane
• 英文别名: 1,2-Bis-phenylacetoxy-aethan；2-(2-Phenylacetyl)oxyethyl 2-phenylacetate
• CAS: 70632-18-7
• 化学式: C₁₈H₁₈O₄
• 分子量: 298.339
• InChiKey: IXNXYZKILJGOMS-UHFFFAOYSA-N

物化性质

• 熔点：
  317-321 °C
• 沸点：
  425.8±25.0 °C(Predicted)
• 密度：
  1.165±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,2-bis-phenylacetoxy-ethane 在 对甲苯磺酰叠氮 、 (3aS,3a'S,8aR,8a'R)-2,2'-(1,3-双(3,5-二叔丁基苯基)丙烷-2,2-二基)双(8,8a-二氢-3aH-茚并[1,2-d]恶唑) 、 copper(II) bis(trifluoromethanesulfonate) 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 四(3,5-二(三氟甲基)苯基)硼酸钠 作用下， 以 二氯甲烷 、 乙酸乙酯 、 乙腈 为溶剂， 反应 18.5h， 生成 (2R,2'R)-(-)-2,2'-(1,4-phenylenebis(dimethylsilanediyl))bis(2-phenylethan-1-ol)
  参考文献：
  名称：

  铜催化Si-H键插入聚合合成含硅光学活性聚酯

  摘要：

  具有不同结构的手性聚合物的合成和表征仍然是一个长期具有挑战性的研究课题。在此，将铜催化的卡宾对映选择性插入到Si-H键中进行缩聚反应，得到了一种新型的主链含有Si-C键的旋光可降解聚酯。该聚合反应条件温和，底物范围广，收率高，对映选择性好。手性二醇可以通过光学活性聚酯的还原获得。热重分析表明这些手性聚酯表现出良好的热稳定性。

  DOI：

  10.1002/cjoc.202100569
• 作为产物：
  描述：

  苯乙酸 、 乙二醇 在 硫酸 作用下， 以36%的产率得到1,2-bis-phenylacetoxy-ethane
  参考文献：
  名称：

  Mikhant'eva, O. N.; Romanova, V. S.; Mikhant'ev, V. B., Journal of applied chemistry of the USSR, 1981, vol. 54, # 5, p. 990 - 993

  摘要：

  DOI：

文献信息

• Tabenkin et al., Archives of Biochemistry, 1952, vol. 38, p. 43,44
  作者：Tabenkin et al.

  DOI：——

  日期：——
• Synthese 2-substituierter Imidazoline: 2-Benzyl-imidazolin
  作者：G. Kubiczek、A. Smahel

  DOI：10.1007/bf00897772

  日期：1949.5
• Fentanyl is more effective than remifentanil at preventing increases in cerebral blood flow velocity during intubation in children
  作者：Claude Abdallah、Cengiz Karsli、Bruno Bissonnette

  DOI：10.1007/bf03017905

  日期：2002.12

  Purpose: Controlling the cerebral and systemic hemodynamic responses to laryngoscopy and tracheal intubation may play a role in determining clinical outcome in pediatric neurosurgical patients. This study compared the effects of remifentanil and fentanyl on cerebral blood flow velocity (CBFV) and hemodynamic profile during laryngoscopy and tracheal intubation in children under sevoflurane anesthesia.Methods: Sixty healthy children aged two to six years undergoing dental surgery under general anesthesia were enrolled. Each child was randomly assigned to receive a remifentanil or fentanyl infusion, at a rate of 0.75, 1.0, or 1.5 mug(.)kg(-1.)min(-1) after induction of anesthesia with 2% sevoflurane. Middle cerebral artery blood flow velocity was measured by transcranial Doppler (TCD) sonography. Once a baseline set of hemodynamic variables and TCD measurements were recorded, the opioid infusion was started. Measurements were taken at two-minute intervals, starting four minutes prior to laryngoscopy until four minutes following naso-tracheal intubation.Results: Remifentanil caused a more significant decrease in mean arterial pressure and CBFV prior to tracheal intubation than did fentanyl (P < 0.001). During laryngoscopy and for two minutes following tracheal intubation, CBFV increased in all remifentanil groups (P < 0.05), whereas it remained stable in all fentanyl groups.Conclusion: This study suggests that fentanyl was more effective than remifentanil at preventing increases in CBFV during and immediately following laryngoscopy and tracheal intubation in children undergoing sevoflurane anesthesia. Fentanyl also seemed to provide a more stable hemodynamic profile prior to laryngoscopy and tracheal intubation when compared to remifentanil.
• Assemble four-arm DNA junctions into nanoweb
  作者：Chunqing Zhou、Zukun Tan、Chen Wang、Chunli Bai、Enhua Cao

  DOI：10.1007/bf02900620

  日期：2001.10

  DNA is of structural polymorphism, which is useful in nanoarchitecture; especially, four-arm DNA junctions can be used to assemble nanowebs. The static four-arm DNA junctions were designed and synthesized. One-arm DNA and two-arm DNA came out simultaneously with the four-arm DNA junction's formation. A new method, termed the two-step method, was proposed and the productivity of four-arm DNA junctions was Increased. A nanoweb was assembled successfully, but it showed irregularity itself. It was not the same as we expected. We consider that it is a result from the flexibility of four-arm DNA junction.
• MIXANTEVA O. N.; VOISHCHEVA O. V.; POMAHOBA V. S.; MIXANTEV V. B., IZV. VUZOV. XIMIYA I XIM. TEXNOL., 1981, 24, HO 6, 681-684
  作者：MIXANTEVA O. N.、 VOISHCHEVA O. V.、 POMAHOBA V. S.、 MIXANTEV V. B.

  DOI：——

  日期：——