N-benzyloxycarbonyl-leucyl-leucyl-phenylalanal | 133429-58-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-benzyloxycarbonyl-leucyl-leucyl-phenylalanal
• 英文别名: (benzyloxycarbonyl)-Leu-Leu-phenylalaninal；Cbz-Leu-Leu-Phe-CHO；Z-Leu-Leu-Phe-CHO；ZLLF-CHO；Z-Leu-Leu-Phe-H；PS-II；benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-phenylpropan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
• CAS: 133429-58-0
• 化学式: C₂₉H₃₉N₃O₅
• 分子量: 509.646
• InChiKey: LIOIGKLWXFXXEG-GSDHBNRESA-N

物化性质

• 沸点：
  732.8±60.0 °C(Predicted)
• 密度：
  1.122±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  37
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (S)-2-amino-N-methoxy-N-methyl-3-phenylpropanamide 在 lithium aluminium tetrahydride 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 生成 N-benzyloxycarbonyl-leucyl-leucyl-phenylalanal
  参考文献：
  名称：

  Peptide inhibitors of IKB protease: Modification of the C-termini of Z-LLF-CHO

  摘要：

  A series of tripeptides (Z-LLF-R) with various modifications at their C-terminus were synthesized and evaluated for their ability to prevent the activation of NF-kappa B through inhibition of I kappa B protease. Of the compounds evaluated only the C-terminal aldehydes 5a,b were active in our Jurkat T-cell based assay. Compound 5a also decreased IL-2 and IL-8 levels in these cells indicating that inhibitors of I kappa B protease can have an effect on various signaling pathways. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00559-8

文献信息

• [EN] ANTI-TM4SF1 ANTIBODY DRUG CONJUGATES AND METHODS OF USING SAME<br/>[FR] CONJUGUÉS ANTICORPS ANTI-TM4SF-MÉDICAMENT ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ANGIEX INC

  公开号：WO2021222783A1

  公开（公告）日：2021-11-04

  Antibody-drug conjugates (ADCs) are described, comprising anti-TM4SF1 antibodies, antigen-binding fragments thereof, a linker and a drug. Methods of use of said ADCs are also describe.

  抗体药物偶联物（ADCs）被描述为包括抗TM4SF1抗体、其抗原结合片段、连接剂和药物。还描述了使用这些ADCs的方法。
• Proteasome regulation of NF-kB activity
  申请人：Harvard College

  公开号：US20040097420A1

  公开（公告）日：2004-05-20

  Disclosed herein is a method for regulating the activity of NF-&kgr;B in an animal comprising contacting cells of the animal with certain proteasome inhibitors.

  本文公开了一种调节动物NF-&kgr;B活性的方法，包括将动物细胞与某些蛋白酶体抑制剂接触。
• Method for regulation of NF-kB
  申请人：YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

  公开号：EP0652290A1

  公开（公告）日：1995-05-10

  Methodology for identifying compositions which affect NF-κB activation via IκBα regulation and uses therefor are described. Also described are IκBα-protease inhibitors useful in the methods of the invention.

  本发明描述了识别通过 IκBα 调节影响 NF-κB 激活的组合物的方法及其用途。此外，还介绍了用于本发明方法的 IκBα 蛋白酶抑制剂。
• Flaxseed lignan complex, methods of using and compositions thereof
  申请人：Christofidou-Solomidou Melpo

  公开号：US10449224B2

  公开（公告）日：2019-10-22

  This invention relates to methods and compositions for treating pathological lung conditions using whole-grain flaxseed or flaxseed lignans (isolated in form of the lignan precursor Secoisolariciresinol diglucoside (SDG) directly from whole-grain flaxseed or chemically synthesized directly into the mammalian, readily metabolizable forms, Enterodiol (ED) or Enterolactone (EL). Such pathological condition result from oxidative lung injury such as ischemia-reperfusion injury (related to lung transplantation), radiation fibrosis and cancer. Specifically, the invention is directed to the use of flaxseed lignans in the treatment of acute and chronic lung injury as well as cancer.

  本发明涉及使用全粒亚麻籽或亚麻籽木脂素（直接从全粒亚麻籽中分离出木脂素前体 Secoisolariciresinol diglucoside (SDG)，或直接化学合成哺乳动物易代谢形式 Enterodiol (ED) 或 Enterolactone (EL)）治疗病理性肺部疾病的方法和组合物。 这种病理状态源于氧化性肺损伤，如缺血再灌注损伤（与肺移植有关）、放射性纤维化和癌症。 具体而言，本发明涉及亚麻籽木酚素在治疗急性和慢性肺损伤以及癌症中的应用。
• Method for identification of proteins from intracellular bacteria
  申请人：——

  公开号：US20030199438A1

  公开（公告）日：2003-10-23

  The present invention relates to a novel combination of methods that enables identification of proteins secreted from intracellular bacteria regardless of the secretion pathway. The invention further provides proteins that are identified by these methods. Secreted proteins are known to be suitable candidates for inclusion in immunogenic compositions and/or diagnostic purposes. The invention also provides peptide epitopes (T-cell epitopes) from the identified secreted proteins, as well as nucleic acid compounds that encode the proteins. The invention further comprises various applications of the proteins or fragments thereof, such as pharmaceutical and diagnostic applications.

  本发明涉及一种新颖的方法组合，可鉴定细胞内细菌分泌的蛋白质，而不论其分泌途径如何。本发明进一步提供了通过这些方法鉴定的蛋白质。众所周知，分泌蛋白适合用于免疫原组合物和/或诊断目的。本发明还提供了来自已鉴定的分泌蛋白的肽表位（T 细胞表位）以及编码这些蛋白的核酸化合物。本发明还包括蛋白质或其片段的各种应用，如制药和诊断应用。