(R)-N,N-dimethyl-2-((R)-1-morpholino-1,2-dioxopentan-3-yl)-3-oxohexanamide | 1167458-47-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-N,N-dimethyl-2-((R)-1-morpholino-1,2-dioxopentan-3-yl)-3-oxohexanamide
• 英文别名: (2R)-N,N-dimethyl-2-[(3R)-1-morpholin-4-yl-1,2-dioxopentan-3-yl]-3-oxohexanamide
• CAS: 1167458-47-0
• 化学式: C₁₇H₂₈N₂O₅
• 分子量: 340.42
• InChiKey: HCYOWILBUSIALK-TZMCWYRMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  84
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(morpholin-4-yl)-2-oxoacetaldehyde 、 (Z)-N,N-dimethyl-3-oxo-2-propylidenehexanamide 在 BF₄^(1-)*C₁₈H₁₃F₅N₃⁽¹⁺⁾ 、 magnesium sulfate 、 N,N-二异丙基乙胺 作用下， 以 四氯化碳 为溶剂， 反应 12.0h， 生成 N,N-dimethyl-2-(1-morpholino-1,2-dioxopentan-3-yl)-3-oxohexanamide 、 (R)-N,N-dimethyl-2-((R)-1-morpholino-1,2-dioxopentan-3-yl)-3-oxohexanamide
  参考文献：
  名称：

  Enantio- and Diastereoselective Intermolecular Stetter Reaction of Glyoxamide and Alkylidene Ketoamides

  摘要：

  A triazolinylidene carbene catalyzed intermolecular Stetter reaction of glyoxamide and alkylidene ketoamides has been developed. 1,4-Dicarbonyl products are afforded in good to excellent yields, enantioselectivities, and diastereoselectivities. Further derivatization of the products affords useful intermediates for organic synthesis.

  DOI：

  10.1021/ol901081a

文献信息

• Enantio- and Diastereoselective Intermolecular Stetter Reaction of Glyoxamide and Alkylidene Ketoamides
  作者：Qin Liu、Tomislav Rovis

  DOI：10.1021/ol901081a

  日期：2009.7.2

  A triazolinylidene carbene catalyzed intermolecular Stetter reaction of glyoxamide and alkylidene ketoamides has been developed. 1,4-Dicarbonyl products are afforded in good to excellent yields, enantioselectivities, and diastereoselectivities. Further derivatization of the products affords useful intermediates for organic synthesis.