2-马来酰亚胺乙酸肼 | 765868-52-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-马来酰亚胺乙酸肼
• 英文名称: 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetohydrazide
• 英文别名: 2-(2,5-dioxopyrrol-1-yl)acetohydrazide
• CAS: 765868-52-8
• 化学式: C₆H₇N₃O₃
• mdl: MFCD11519206
• 分子量: 169.14
• InChiKey: GVGAQZDNPZWHHD-UHFFFAOYSA-N

物化性质

• 沸点：
  461.1±28.0 °C(Predicted)
• 密度：
  1.493±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  92.5
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2928000090

文献信息

• ANTHRACYCLINE DERIVATIVE CONJUGATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR COMPOUNDS
  申请人：Beria Italo

  公开号：US20100034837A1

  公开（公告）日：2010-02-11

  The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.

  本发明涉及治疗有用的蒽环类药物与载体（如多克隆和单克隆抗体、天然或合成来源的蛋白质或肽）的结合物，其制备方法，含有它们的药物组合物以及在治疗某些哺乳动物肿瘤中的应用。
• PESTICIDE BIOMARKER
  申请人：Nagy Jon Owen

  公开号：US20100041077A1

  公开（公告）日：2010-02-18

  Provided are methods, compositions and articles of manufacture for detecting biomarkers indicative of exposure of a mammal to organophosphate compounds. The interaction of such a biomarker with a receptor bound to a biopolymer results in an optical readout that reports the presence of the biomarker.
• BIOMARKER DETECTION-2
  申请人：Nagy Jon Owen

  公开号：US20110166043A1

  公开（公告）日：2011-07-07

  Provided are methods, compositions and articles of manufacture for detecting biomarkers indicative of exposure of a mammal to organophosphate compounds. The organophosphate compound includes pesticides, their metabolites and highly reactive organophosphoryl compounds. In one aspect of the invention, the biomarker results from interaction of the organophosphate compound with a polypeptide such as a serine hydrolase that includes acetylcholiestersae. The interaction of a biomarker so derived with a optical sensor comprising a receptor bound to a biopolymer results in an optical readout that reports the presence of the biomarker. In one aspect of the invention the receptor that is bound to a biopolymer, such as a poly-di-acetylene polymer, is a antibody that selectively recognizes the biomarker.
• VITAMIN RECEPTOR BINDING DRUG DELIVERY CONJUGATES
  申请人：ENDOCYTE, INC.

  公开号：US20140058063A1

  公开（公告）日：2014-02-27

  The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.
• Pesticide Biomarker
  申请人：Nagy Jon Owen

  公开号：US20140162906A1

  公开（公告）日：2014-06-12

  Provided are methods, compositions and articles of manufacture for detecting biomarkers indicative of exposure of a mammal to organophosphate compounds. The interaction of such a biomarker with a receptor bound to a biopolymer results in an optical readout that reports the presence of the biomarker.