ethyl 3,4-diphenyl-1H-pyrazole-1-acetate | 120982-79-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 3,4-diphenyl-1H-pyrazole-1-acetate
• 英文别名: ethyl 2-(3,4-diphenylpyrazol-1-yl)acetate
• CAS: 120982-79-8
• 化学式: C₁₉H₁₈N₂O₂
• 分子量: 306.364
• InChiKey: YKSJJQYWNXLVLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 3,4-diphenyl-1H-pyrazole-1-acetate 生成 N-[3-(dimethylamino)propyl]-2-(3,4-diphenylpyrazol-1-yl)acetamide
  参考文献：
  名称：

  BAILEY, DENIS M.

  摘要：

  DOI：
• 作为产物：
  描述：

  肼基乙酸乙酯盐酸盐 、 3-oxo-2,3-diphenylpropanal 生成 ethyl 3,4-diphenyl-1H-pyrazole-1-acetate
  参考文献：
  名称：

  BAILEY, DENIS M.

  摘要：

  DOI：

文献信息

• N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmic
  申请人：Sterling Drug Inc.

  公开号：US04898880A1

  公开（公告）日：1990-02-06

  N-[(heterocycle)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl) amine or by reacting a pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl)amine.

  N-[(杂环)烷基]-3,4（或4,5）-二芳基-1H-吡唑-1-乙酰胺和吡唑-1-丙酰胺，用于治疗哺乳动物的心律失常，通过将吡唑-1-乙酸或丙酸的低烷基酯与适当的（杂环烷基）胺反应或将吡唑-1-乙酸或丙酸与适当的（杂环烷基）胺反应来制备。
• 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use
  申请人：Sterling Drug Inc.

  公开号：US04916150A1

  公开（公告）日：1990-04-10

  N-[alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.

  N-[烷基氨基)烷基]-3,4(或4,5)-二芳基-1H-吡唑-1-(支链)烷酰胺和用于治疗哺乳动物心律失常的吡唑-1-烷胺，通过将吡唑-1-乙酸的较低烷基酯与适当的二胺反应后进行还原制备，或者通过将吡唑-1-乙酸较低烷基酯的阴离子与烷基化剂反应后再通过适当胺进行酯的置换制备。
• 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use
  申请人：Sterling Drug, Inc.

  公开号：US04870095A1

  公开（公告）日：1989-09-26

  N-[(disubstituted amino)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate diamine or by reacting a lower-alkyl ester of a pyrazole-1-acetic or propanoic acid with an .omega.-aminoalkanol, followed by activation of the alcohol and displacement by an appropriate amine.

  N-[(二取代氨基)烷基]-3,4(或4,5)-二芳基-1H-吡唑-1-乙酰胺和吡唑-1-丙酰胺，用于治疗哺乳动物心律失常，通过将吡唑-1-乙酸或丙酸的较低烷基酯与适当的二胺反应制备，或通过将吡唑-1-乙酸或丙酸的较低烷基酯与.ω.-氨基烷醇反应，随后激活醇并被适当胺置换而制备。
• 1H-pyrazole-1-(branched)alkanamides as antiarrhythmic agents,
  申请人：Sterling Drug Inc.

  公开号：US04988725A1

  公开（公告）日：1991-01-29

  N-[(alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.

  用于治疗哺乳动物心律失常的N-[(烷基)氨基烷基]-3,4或4,5-二芳基-1H-吡唑-1-(支链)烷酰胺和吡唑-1-烷胺，通过将吡唑-1-乙酸较低烷基酯与适当的二胺反应后还原或通过将较低烷基吡唑-1-乙酸酯的阴离子与烷基化试剂反应后，再用适当的胺取代酯来制备。
• 1H-pyrazole-1-alkanamides and preparation useful as antiarrhythmic agents
  申请人：STERLING DRUG INC.

  公开号：EP0299407A1

  公开（公告）日：1989-01-18

  N-[(disubstituted amino)alkyl]-3,4 (or 4,5)-diaryl-­1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester or pyrazole-1-acetic or propanoic acid with an appropriate diamine or by reacting a lower-alkyl ester of a pyrazole-1-acetic or propanoic acid with an ω-­aminoalkanol, followed by activation of the alcohol and displacement of an appropriate amine.

  N-[(二取代氨基)烷基]-3,4(或 4,5)-二芳基-1H-吡唑-1-乙酰胺和吡唑-1-丙酰胺，可用于治疗哺乳动物的心律失常、其制备方法是将吡唑-1-乙酸或丙酸的低级烷基酯与适当的二胺反应，或将吡唑-1-乙酸或丙酸的低级烷基酯与ω-氨基醇反应，然后使醇活化并置换适当的胺。