Gly-Pro-Leu | 47066-32-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Gly-Pro-Leu
• 英文别名: GPL；N-(1-glycyl-L-prolyl)-L-leucine；N-(1-Glycyl-L-prolyl)-L-leucin；(2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-4-methylpentanoic acid
• CAS: 47066-32-0
• 化学式: C₁₃H₂₃N₃O₄
• 分子量: 285.343
• InChiKey: HFPVRZWORNJRRC-UWVGGRQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  Z-甘氨酸-脯氨酸 在 甲醇 、 palladium on activated charcoal 、 溶剂黄146 、 异戊酰氯 作用下， 生成 Gly-Pro-Leu
  参考文献：
  名称：

  Synthesis of Poly-(L-prolyl-L-leucyl-glycyl). An Attempted Synthesis of Model Collagen

  摘要：

  合成了两种三肽--l-脯氨酰-亮氨酰甘氨酸（IV）和甘氨酰-l-脯氨酰-亮氨酸（X），并用焦磷酸四乙酯法、碳化二亚胺法和对硝基苯硫酯法对 IV 进行了聚合，其中焦磷酸法的聚合效果最好。得到的多肽的最高分子量约为 6000，通过末端基团的测定，证实了多肽中原有三肽单元的重复。用焦磷酸四乙酯法对 IV 和 X 两种三肽的缩聚反应进行了平行比较，结果表明，IV 比 X 的产率更高、分子量更大。

  DOI：

  10.1246/bcsj.31.802

文献信息

• Detection of Bacteroides gingivalis
  申请人：THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

  公开号：EP0292708A2

  公开（公告）日：1988-11-30

  The present invention relates to the detection of B. gingivalis by the specific ability of B. gingivalis to hydrolyze N-carbobenzoxy-glycyl-glycyl-L-arginine-B-napthylamide deriva­tives. The present invention also relates to the use of assay systems which inhibit serum amino peptidase and enhance the detection of the B. gingivalis N-CBz-Gly-Gly-Arg peptidase. The assay system inhibits the serum enzyme by the use of a serum aminopeptidase inhibitor which inhibits the activity of serum aminopeptidase to a greater extent than it inhibits the activity of B. gingivalis N-CBz-Gly-Gly-Arg peptidase. The assay system also increases the reliability of detection of the B. gingivalis enzyme by the use of enhancing materials which enhance the enzyme activity of B. gingivalis N-CBz-Gly-Gly-Arg peptidase to a greater extent than such materials enhance the enzyme activity of serum aminopeptidase.

  本发明涉及通过牙龈杆菌水解 N-羧基苯氧基-甘氨酰-甘氨酰-L-精氨酰-B-萘酰胺衍生物的特异性能力来检测牙龈杆菌。本发明还涉及抑制血清氨基肽酶并提高牙龈杆菌 N-CBz-Gly-Gly-Arg 肽酶检测能力的检测系统的使用。该检测系统通过使用血清氨基肽酶抑制剂来抑制血清酶，该抑制剂对血清氨基肽酶活性的抑制程度大于对牙龈杆菌 N-CBz-Gly-Gly-Arg 肽酶活性的抑制程度。该检测系统还通过使用增强材料提高牙龈杆菌 N-CBz-Gly-Gly-Arg 肽酶的酶活性，其增强程度大于此类材料对血清氨肽酶酶活性的增强程度，从而提高检测牙龈杆菌酶的可靠性。
• Synthesis of Poly-(L-prolyl-L-leucyl-glycyl). An Attempted Synthesis of Model Collagen
  作者：Hidetoshi Kitaoka、Shumpei Sakakibara、Hisaya Tani

  DOI：10.1246/bcsj.31.802

  日期：1958.7

  The two tripeptides, l-prolyl-l-leucylglycine (IV) and glycyl-l-prolyl-l-leucine (X), were synthesized, and IV was subjected to polymerization by the tetraethyl pyrophosphite, carbodiimide and p-nitrophenyl thioester methods, in which the most promising result was obtained by the pyrophosphite method. The highest molecular weight of the polypeptide which was obtained was about 6000 and the repetition of the original tripeptide unit in the polypeptide was confirmed by the end groups determination. The polycondensation reactions of both the tripeptides, IV and X, were compared in parallel runs by the tetraethyl pyrophosphite procedure, and the comparison showed that IV gave a better yield and a higher molecular weight product than X. X and poly-(l-prolyl-l-leucyl-glycyl), which was obtained from IV, contained firmly bound water in spite of the fact that IV contained no crystallization water.

  合成了两种三肽--l-脯氨酰-亮氨酰甘氨酸（IV）和甘氨酰-l-脯氨酰-亮氨酸（X），并用焦磷酸四乙酯法、碳化二亚胺法和对硝基苯硫酯法对 IV 进行了聚合，其中焦磷酸法的聚合效果最好。得到的多肽的最高分子量约为 6000，通过末端基团的测定，证实了多肽中原有三肽单元的重复。用焦磷酸四乙酯法对 IV 和 X 两种三肽的缩聚反应进行了平行比较，结果表明，IV 比 X 的产率更高、分子量更大。