1-t-butyl-2-valerylhydrazine | 112735-42-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-t-butyl-2-valerylhydrazine
• 英文别名: N'-tert-butylpentanehydrazide
• CAS: 112735-42-9
• 化学式: C₉H₂₀N₂O
• 分子量: 172.271
• InChiKey: SMFQTMDBKMWEHN-UHFFFAOYSA-N

物化性质

• 沸点：
  217.0±13.0 °C(Predicted)
• 密度：
  0.897±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,5-二甲基苯甲酰氯 、 1-t-butyl-2-valerylhydrazine 在 sodium hydroxide 作用下， 以 乙醚 为溶剂， 反应 48.0h， 生成 N-tert-butyl-3,5-dimethyl-N'-pentanoylbenzohydrazide
  参考文献：
  名称：

  Molting hormonal and larvicidal activities of aliphatic acyl analogs of dibenzoylhydrazine insecticides

  摘要：

  Dibenzoylhydrazines are the nonsteroidal ecdysone agonists. Using comparative molecular field analysis, we previously found that the alkyl side chain of 20-hydroxyecdysone (20E) is three-dimensionally superposable with one of their two aryl moieties. Td identify the aryl moiety that is better superposable on the alkyl chain, we synthesized compounds in which one of the two aryl groups of tebufenozide (N-t-butyl-N-3,5-dimethylbenzoyl-N'-4-ethylbenzoylhydrazine) is replaced by alkyl groups such as C4H9, C5H11, and C6H13. The molting hormonal activity of these compounds was measured using cultured integuments prepared from rice stem borers, Chile suppressalis Walker, in terms of stimulation of incorporation of N-acetyl-[C-14]glucosamine. N-t-Butyl-N-3,5- dimethylbenzoyl-N'-acylhydrazines with a hexanoyl or heptanoyl group were about 20-fold higher than that of 20E, whereas N-acyl-N-t-butyl-N'-4-ethylbenzoylhydrazines with a hexanoyl or heptanoyl group were much weaker than 20E. Their larvicidal activity wets also measured against rice stem borers. The former series of compounds were much more active than the other series as well as 20E. Thus, the benzoyl moiety of dibenzoylhydrazines, which is bound to the secondary nitrogen atom(-NH-), is replaceable by aliphatic acyl groups without greatly, affecting the biological activities. (C) 1997 by Elsevier Science Inc.

  DOI：

  10.1016/s0039-128x(97)00049-4
• 作为产物：
  描述：

  叔丁基肼盐酸盐 、 戊酰氯 在 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 48.0h， 生成 1-t-butyl-2-valerylhydrazine
  参考文献：
  名称：

  Molting hormonal and larvicidal activities of aliphatic acyl analogs of dibenzoylhydrazine insecticides

  摘要：

  Dibenzoylhydrazines are the nonsteroidal ecdysone agonists. Using comparative molecular field analysis, we previously found that the alkyl side chain of 20-hydroxyecdysone (20E) is three-dimensionally superposable with one of their two aryl moieties. Td identify the aryl moiety that is better superposable on the alkyl chain, we synthesized compounds in which one of the two aryl groups of tebufenozide (N-t-butyl-N-3,5-dimethylbenzoyl-N'-4-ethylbenzoylhydrazine) is replaced by alkyl groups such as C4H9, C5H11, and C6H13. The molting hormonal activity of these compounds was measured using cultured integuments prepared from rice stem borers, Chile suppressalis Walker, in terms of stimulation of incorporation of N-acetyl-[C-14]glucosamine. N-t-Butyl-N-3,5- dimethylbenzoyl-N'-acylhydrazines with a hexanoyl or heptanoyl group were about 20-fold higher than that of 20E, whereas N-acyl-N-t-butyl-N'-4-ethylbenzoylhydrazines with a hexanoyl or heptanoyl group were much weaker than 20E. Their larvicidal activity wets also measured against rice stem borers. The former series of compounds were much more active than the other series as well as 20E. Thus, the benzoyl moiety of dibenzoylhydrazines, which is bound to the secondary nitrogen atom(-NH-), is replaceable by aliphatic acyl groups without greatly, affecting the biological activities. (C) 1997 by Elsevier Science Inc.

  DOI：

  10.1016/s0039-128x(97)00049-4

文献信息

• Anthelmintic N'-substituted-N,N'-disubstitutedhydrazines
  申请人：Rohm and Haas Company

  公开号：US05424333A1

  公开（公告）日：1995-06-13

  This invention relates to the anthelmintic use of compositions containing N'-substituted-N,N'-disubstitutedhydrazines. Specifically, the invention relates to methods of controlling helminths by contacting the helminths with a compound having a nucleus of the formula ##STR1## wherein X and X' are the same or different O, S, or NR and A', B', R.sup.1 and R.sup.2 are a variety of substituents.

  本发明涉及含有N'-取代的N,N'-二取代腙类化合物的驱虫用途。具体来说，本发明涉及通过将具有以下结构式核的化合物与蠕虫接触来控制蠕虫的方法：##STR1##其中X和X'是相同或不同的O、S或NR，A'、B'、R1和R2是各种取代基。
• Insecticidal N' substituted-N-N'-disubstituted-hydrazines
  申请人：Rohm and Haas Company

  公开号：US05117057A1

  公开（公告）日：1992-05-26

  This invention relates to insecticidal compositions containing N'-substituted-N,N'-disubstitutedhydrazines, methods of using such compositions and N'-substituted-N, N'-disubstitutedhydrazines. Specifically, the invention relates to insect growth regulating compositions, and methods of using such compositions, which include compounds having a nucleus of the formula ##STR1## where A', B', D and J are independently any atom or group of atoms; where E is a tertiary carbon containing organic radical, a haloalkyl having a total of at least four carbon and halogen atoms but not more than six halogen atoms, or a non-tertiary carbon containing non-haloalkyl organic or organometallic radical having at least five atoms other than hydrogen, oxygen and halogen, and is attached to the nitrogen shown in the formula by a carbon-to-nitrogen single bond; where one G.sub.1 is C, N, O and S, and both G.sub.2 's and the other G.sub.1 are carbon; or one G.sub.2 is S or P, and both G.sub.1 's and the other G.sub.2 are carbon; where the bonds shown as - - - are independently single or double bonds; where the A'-?-G.sub.1 and G.sub.1 -?-B' bonds are independently single bond, double bonds or aromatic bonds; where organic radical is a radical comprising at least one carbon atom, but no metal atoms; where organometallic radical is a radical containing a carbon-to-metal bond; or an agronomically acceptable salt thereof; and with the provisos discussed infra.

  本发明涉及含有N'-取代-N，N'-二取代腙的杀虫组合物，使用这种组合物和N'-取代-N，N'-二取代腙的方法。具体而言，本发明涉及昆虫生长调节剂组合物及使用这种组合物的方法，其中包括具有以下式子的核的化合物：##STR1## 其中A'，B'，D和J分别是任何原子或原子团；E是含有三级碳的有机基团，是具有至少四个碳和卤素原子总数但不超过六个卤素原子的卤代烷基，或是具有至少五个除氢，氧和卤素之外的原子的非三级碳含量的非卤代烷基有机或有机金属基团，并通过碳-氮单键连接到式中所示的氮；其中一个G.sub.1是C，N，O和S，而两个G.sub.2和另一个G.sub.1是碳；或其中一个G.sub.2是S或P，而两个G.sub.1和另一个G.sub.2是碳；其中所示的- - -键是独立的单键或双键；其中A'-?-G.sub.1和G.sub.1-?-B'键是独立的单键，双键或芳香键；有机基团是至少含有一个碳原子但不含金属原子的基团；有机金属基团是含有碳-金属键的基团；或其农业上可接受的盐；在满足下述条件的情况下。
• RUBBER COMPOSITION AND PNEUMATIC TIRES
  申请人：Bridgestone Corporation

  公开号：EP0909788A1

  公开（公告）日：1999-04-21

  A rubber composition prepared by compounding 0.05 to 20 parts by weight of at least one selected from substituted hydrazide compounds represented by the following Formulas (I) to (IV) per 100 parts by weight of a rubber component comprising at least one rubber selected from the group consisting of natural rubber and synthetic rubber, and a pneumatic tire using the same: wherein A represents one selected from the group consisting of an aromatic group which may have a substituent, a hydantoin ring which may have a substituent, and a saturated or unsaturated linear hydrocarbon having 1 to 18 carbon atoms; Y represents hydrogen, an amino group, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group, an alkenyl group, an aromatic group, a pyridyl group or hydrazino group; and R1 to R11 each represent hydrogen, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group or an aromatic group.

  一种橡胶组合物，其制备方法是每 100 重量份由至少一种选自天然橡胶和合成橡胶组的橡胶组成的橡胶组分中混入 0.05 至 20 重量份的至少一种选自下式(I)至(IV)所代表的取代酰肼化合物，以及使用该组合物的充气轮胎： 其中 A 代表选自芳香基团（可具有取代基）、海因环（可具有取代基）和具有 1 至 18 个碳原子的饱和或不饱和线性烃；Y 代表氢、氨基、具有 1 至 18 个碳原子的烷基、环烷基、烯基、芳香基、吡啶基或肼基；R1 至 R11 分别代表氢、具有 1 至 18 个碳原子的烷基、环烷基或芳香基。
• Rubber composition and pneumatic tire
  申请人：Bridgestone Corporation

  公开号：EP1420044A2

  公开（公告）日：2004-05-19

  A hydrazone derivative represented by Formula (V):         ZC(=O)NHN=C(CH3) (CH2CH(CH3)2)     (V) wherein Z represents 3-hydroxy-2-naphthyl, 1-hydroxy-2-naphthyl, 2-hydroxyphenyl or 2,6-dihydroxyphenyl group.

  式 (V) 所代表的腙衍生物： ZC(=O)NHN=C(CH3) (CH2CH(CH3)2) (V) 其中 Z 代表 3-羟基-2-萘基、1-羟基-2-萘基、2-羟基苯基或 2,6-二羟基苯基。
• Insecticidal N'-substituted-N-alkylcarbonyl-N'-acyl hydrazines
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0232075B1

  公开（公告）日：1991-03-13