3-(2-Methyl-1-pyrrolidyl)propyl chloride | 792137-25-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-(2-Methyl-1-pyrrolidyl)propyl chloride
• 英文别名: 1-(3-chloro-propyl)-2-methyl-pyrrolidine；1-(3-Chlor-propyl)-2-methyl-pyrrolidin；1-(3-chloropropyl)-2-methylpyrrolidine
• CAS: 792137-25-8
• 化学式: C₈H₁₆ClN
• 分子量: 161.675
• InChiKey: BAKHPYGIWRQPMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(2-Methyl-1-pyrrolidyl)propyl chloride 在 potassium carbonate 作用下， 以 丁酮 为溶剂， 生成 2-Methyl-1-pyrrolidinepropyl p-hydroxybenzoate hydrochloride
  参考文献：
  名称：

  具有潜在药理活性的新化合物

  摘要：

  DOI：

  10.1021/je60085a001
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氯化亚砜 、 氯仿 作用下， 生成 3-(2-Methyl-1-pyrrolidyl)propyl chloride
  参考文献：
  名称：

  3-(methylpyrrolidyl-1)propyl para(delta 2)-cyclohexenyloxybenzoates and salts thereof

  摘要：

  公开号：

  US02576970A1

文献信息

• 3- Or 4-monosubstituted phenol derivatives useful as H3 ligands
  申请人：Warner-Lambert Company LLC

  公开号：EP1593679A1

  公开（公告）日：2005-11-09

  The invention relates to 3- or 4-monosubstituted phenol derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol derivatives are H3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

  这项发明涉及3-或4-单取代酚衍生物，以及用于制备、制备中间体、含有和使用这些衍生物的过程。所述的3-或4-单取代酚衍生物是H3配体，在许多疾病、紊乱和状况中非常有用，特别是炎症性、过敏性和呼吸系统疾病、紊乱和状况。
• [EN] H3 ANTAGONISTS CONTAINING PHENOXYPIPERIDINE CORE STRUCTURE<br/>[FR] ANTAGONISTES H3 CONTENANT UNE STRUCTURE DE NOYAU PHÉNOXYPIPÉRIDINE
  申请人：RICHTER GEDEON NYRT

  公开号：WO2014136075A1

  公开（公告）日：2014-09-12

  The present invention relates to new histamine H 3(H 3) receptor subtype selective ligands of the general formula (I) and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/ or hydrates and/or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and the use of these compounds as medicaments for treatment and/or prevention of conditions which require modulation of H 3receptors. The invention also cover the combinations of a compound of the general formula (I) and an acetylcholinesterase inhibitor.

  本发明涉及一般式(I)的新组胺H3（H3）受体亚型选择性配体和/或几何异构体和/或立体异构体和/或二对映异构体和/或盐和/或水合物和/或溶剂合物。该发明还涉及含有这些化合物的药物组合物以及将这些化合物用作治疗和/或预防需要调节H3受体的疾病的药物。该发明还涵盖一般式(I)化合物和乙酰胆碱酯酶抑制剂的组合物。
• [EN] DIHYDROQUINOLINONE DERIVATIVES<br/>[FR] DERIVES DE DIHYDROQUINOLINONE
  申请人：TAISHO PHARMA CO LTD

  公开号：WO2010090347A1

  公开（公告）日：2010-08-12

  The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases. A dihydroquinolinone derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: [Formula 1] wherein Q represents the following formula (A) or (B)} [Formula 2]

  本发明提供了一种预防或治疗痴呆症、阿尔茨海默病、注意力缺陷多动障碍、精神分裂症、进食障碍、肥胖症、糖尿病、高脂血症、睡眠障碍、嗜睡症、睡眠呼吸暂停综合征、昼夜节律紊乱、抑郁症、过敏性鼻炎或其他疾病的预防或治疗剂。一种由式（1）表示的二氢喹啉酮衍生物或其药用可接受的盐：[式1] 其中Q代表以下式（A）或（B）} [式2]
• 3- or 4-monosubstituted phenol and thiophenol derivatives useful as H3 ligands
  申请人：Bernardelli Patrick

  公开号：US20050267095A1

  公开（公告）日：2005-12-01

  The invention relates to 3- or 4-monosubstituted phenol and thiophenol derivatives of formula (I) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol and thiophenol derivatives are H 3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

  本发明涉及公式(I)的3-或4-单取代苯酚和硫代苯酚衍生物，以及用于制备这些衍生物的中间体、含有这些衍生物的组合物和这些衍生物的用途的过程。所述的3-或4-单取代苯酚和硫代苯酚衍生物是H3配体，在许多疾病、失调和病况中特别有用，特别是在炎性、过敏和呼吸系统疾病、失调和病况中。
• PROCESSES FOR PREPARING (R)-2-METHYLPYRROLIDINE AND (S)-2-METHYLPYRROLIDINE AND TARTRATE SALTS THEREOF
  申请人：Christie Michael

  公开号：US20100121055A1

  公开（公告）日：2010-05-13

  The present invention provides a short, safe, inexpensive, commercially scalable process for preparing (R)- or (S)-2-methylpyrrolidine from 2-methylpyrroline, which does not require the isolation of synthetic intermediates.

  本发明提供了一种从2-甲基吡咯烷制备(R)-或(S)-2-甲基吡咯烷的简短、安全、廉价、商业可扩展的过程，不需要分离合成中间体。