methyl 2-fluoro-2-hexenoate | 112854-11-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 2-fluoro-2-hexenoate
• 英文别名: methyl (E)-2-fluorohex-2-enoate
• CAS: 112854-11-2
• 化学式: C₇H₁₁FO₂
• 分子量: 146.162
• InChiKey: BZMXJODDXYKWHS-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 磺酰氯 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 methyl 2-fluoro-2-hexenoate
  参考文献：
  名称：

  Thia-Wittig-like Reactions as a New Route for the Stereoselective Synthesis of (Z)-Fluoroalkenoates

  摘要：

  [GRAPHICS]Stereoselective syntheses of (Z)-fluoroalkenoates 3a-g have been developed in three steps from the readily available fluorosulfide 5 and aldehydes, This preparation, involving a Durst reaction, was highly stereoselective and led to fluoroalkenes in 50-60% overall yields, without purification of intermediates.

  DOI：

  10.1021/ol990178u

文献信息

• Thia-Wittig-like Reactions as a New Route for the Stereoselective Synthesis of (<i>Z</i>)-Fluoroalkenoates
  作者：David Chevrie、Thierry Lequeux、Jean-Claude Pommelet

  DOI：10.1021/ol990178u

  日期：1999.11.1

  [GRAPHICS]Stereoselective syntheses of (Z)-fluoroalkenoates 3a-g have been developed in three steps from the readily available fluorosulfide 5 and aldehydes, This preparation, involving a Durst reaction, was highly stereoselective and led to fluoroalkenes in 50-60% overall yields, without purification of intermediates.