3,3'-[7,12-二(1-羟基乙基)-3,8,13,17,21-五甲基卟啉-2,18-二基]二丙酸 | 2398-95-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3,3'-[7,12-二(1-羟基乙基)-3,8,13,17,21-五甲基卟啉-2,18-二基]二丙酸
• 中文别名: 膦乳酸；2-[(1,2-二羟基-1-氧代丙烷-2-基)-羟基磷酰]-2-羟基丙酸
• 英文名称: Foscolic acid
• 英文别名: 2-[(1-carboxy-1-hydroxyethyl)-hydroxyphosphoryl]-2-hydroxypropanoic acid
• CAS: 2398-95-0
• 化学式: C₆H₁₁O₈P
• 分子量: 242.12
• InChiKey: RBMHUYBJIYNRLY-UHFFFAOYSA-N

物化性质

• 熔点：
  148.5°C

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  152
• 氢给体数：
  5
• 氢受体数：
  8

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  L-乳酸 、 3,3'-[7,12-二(1-羟基乙基)-3,8,13,17,21-五甲基卟啉-2,18-二基]二丙酸 以 氯仿 为溶剂， 反应 0.5h， 生成 Plla pdla
  参考文献：
  名称：

  A POLYLACTIC ACID STEREOCOMPLEX COMPOSITION, ITS MOLDED PRODUCT, A PROCESS FOR ITS MANUFACTURE AND ITS APPLICATION

  摘要：

  本发明揭示了一种聚乳酸立体互穴复合物组合物以及其制造方法。该发明的组合物包括(a) 30-70重量％的聚(L-乳酸)(PLLA)。(b) 70-30重量％的聚(D-乳酸)(PDLA)和(c) 0.01-10重量％的成核剂，可以通过溶液和熔融混合获得。根据本发明，立体互穴复合物晶体首选形成，PLL或PDLA单体的同晶体（一种晶体形式）不能被观察到。根据本发明，该组合物的熔点温度至少为200℃，比PLL或PDLA单体高约30-50℃。

  公开号：

  US20160272811A1

文献信息

• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• FIXING DEVICE FOR SOFT TISSUE
  申请人：TransEasy Medical Tech. Co., Ltd.

  公开号：EP3195811A1

  公开（公告）日：2017-07-26

  The present invention relates to the field of medical equipment's technology, and more particularly to a fixing device for soft tissue with an absorbable screw or titanium screw. The fixing device for soft tissue includes a driving device, screw tube and a drive rod. A catheter is arranged around the screw tube by screw thread, and a plurality of absorbable screws or titanium screws are arranged in the catheter. A screw thread structure is formed on a nailed beam of each of the absorbable screws, and a lead spring is arranged on each of the absorbable screws structure. The plurality of absorbable screws or titanium screws are connected in series in the form of head to tail connection and put into the catheter with a spiral groove. The driving rod is driven to rotate by the driving device in use under pulling the trigger; further the absorbable screw or titanium screw can be shot out of the catheter one by one when the laparoscopic hernia repair is performing. The fixing device for soft tissue with the absorbable screw or titanium of the present invention is particularly suitable for laparoscopic hernia repair operations. Furthermore, the fixing device for soft tissue of the present invention has characteristics of anti-adhesion, convenient and reliable operation, and the catheter is a detachable replacement element, so the fixing device can be reused after the catheter is replaced

  本发明涉及医疗设备技术领域，尤其涉及一种使用可吸收螺钉或钛螺钉的软组织固定装置。软组织固定装置包括驱动装置、螺纹管和驱动杆。导管通过螺纹布置在螺纹管周围，多个可吸收螺钉或钛螺钉布置在导管中。每个可吸收螺钉的钉梁上都形成了螺纹结构，每个可吸收螺钉结构上都安装有导簧。多个可吸收螺钉或钛螺钉以头尾连接的形式串联，并通过螺旋槽放入导管中。在使用过程中，通过扣动扳机，驱动装置带动驱动杆旋转，从而在进行腹腔镜疝修补术时，将可吸收螺钉或钛合金螺钉逐一从导管中射出。本发明中带有可吸收螺钉或钛的软组织固定装置特别适用于腹腔镜疝气修补手术。此外，本发明的软组织固定装置具有防粘连、操作方便可靠的特点，导管是可拆卸的更换元件，因此更换导管后，固定装置可重复使用。
• Fixing device for soft tissue
  申请人：TransEasy Medical Tech.Co., Ltd

  公开号：US10702264B2

  公开（公告）日：2020-07-07

  A fixing device for soft tissue includes: a driving device, screw tube and a drive rod. A catheter is connected with the screw tube by screw thread, and a plurality of absorbable screws or titanium screws are provided in the catheter. A screw thread structure is formed on a nailed beam of each of the absorbable screws, and a lead spring is provided on each of the absorbable screws. The plurality of absorbable screws or titanium screws are connected in series and provided in the catheter with a spiral groove in a head-to-nail sequence. When used, by pulling the trigger, the driving rod is rotated driven by the driving device, in such a manner that the absorbable screw or the titanium screw can be shot out of the catheter one by one. The fixing device of the present invention has characteristics of anti-adhesion, convenient and reliable operation.

  一种软组织固定装置包括：驱动装置、螺纹管和驱动杆。导管通过螺纹与螺纹管连接，导管内设有多个可吸收螺钉或钛螺钉。每个可吸收螺钉的钉梁上都有螺纹结构，每个可吸收螺钉上都有引线弹簧。多个可吸收螺钉或钛螺钉串联连接，并在导管中按从头到尾的顺序设置螺旋槽。使用时，通过扣动扳机，驱动装置带动驱动杆旋转，从而将可吸收螺钉或钛螺钉逐一从导管中射出。本发明的固定装置具有防粘连、操作方便可靠等特点。
• Methods and devices for the treatment of ocular conditions
  申请人：deJuan Eugene

  公开号：US20060110428A1

  公开（公告）日：2006-05-25

  Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.
• METHODS AND DEVICES FOR THE TREATMENT OF OCULAR CONDITIONS
  申请人：deJuan Eugene

  公开号：US20110159073A1

  公开（公告）日：2011-06-30

  Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.