6-(4-nitrophenyl)morpholin-3-one | 70547-99-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 6-(4-nitrophenyl)morpholin-3-one
• 英文别名: 6-(p-Nitrophenyl)-morpholin-3-on；2-(p-Nitrophenyl)-morpholin-5-on
• CAS: 70547-99-8
• 化学式: C₁₀H₁₀N₂O₄
• 分子量: 222.2
• InChiKey: DZAPLOHCQFZBTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-(4-nitrophenyl)morpholin-3-one 在 硼氘化钠 、 三氟化硼乙醚 作用下， 以 四氢呋喃 为溶剂， 以45%的产率得到
  参考文献：
  名称：

  Balsamo; Ceccarelli; Crotti, European Journal of Medicinal Chemistry, 1982, vol. 17, # 5, p. 471 - 478

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(β-Hydroxy-β-p-nitrophenylethyl)-chloracetamid 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 6-(4-nitrophenyl)morpholin-3-one
  参考文献：
  名称：

  Balsamo; Ceccarelli; Crotti, European Journal of Medicinal Chemistry, 1982, vol. 17, # 5, p. 471 - 478

  摘要：

  DOI：

文献信息

• Diaminopyrimidinecarboxa mide derivative
  申请人：Nagashima Shinya

  公开号：US20050272753A1

  公开（公告）日：2005-12-08

  A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided. A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.

  提供了一种可用于预防或治疗呼吸道疾病，特别是哮喘、慢性阻塞性肺病等与STAT 6有关的化合物。该化合物是一种嘧啶衍生物或其盐，其在2位具有可以被指定取代基取代的芳基氨基或芳基乙基氨基，4位具有被苄基基团或类似基团取代的氨基，5位具有可以被取代的氨基甲酰基。
• Diaminopyrimidinecarboxamide Derivative
  申请人：Nagashima Shinya

  公开号：US20090281072A1

  公开（公告）日：2009-11-12

  A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided. A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.

  提供了一种可用于预防或治疗呼吸系统疾病，特别是哮喘、慢性阻塞性肺疾病等与STAT 6有关的化合物。该化合物为嘧啶衍生物或其盐，其在2位具有可被取代的芳基氨基或芳基乙基氨基基团，4位具有氨基取代的苯甲基基团或类似基团，5位具有可被取代的氨基甲酰基团。
• DIAMINOPYRIMIDINECARBOXAMIDE DERIVATIVE
  申请人：Nagashima Shinya

  公开号：US20110294749A1

  公开（公告）日：2011-12-01

  A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided. A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.

  提供了一种可用于预防或治疗涉及STAT 6的呼吸系统疾病，特别是哮喘、慢性阻塞性肺疾病等的化合物。该化合物为嘧啶衍生物或其盐，其在2位具有可以被指定取代基取代的芳基氨基或芳基乙基氨基基团，在4位具有可以被苄基或类似物取代的氨基基团，并在5位具有可以被取代的氨基甲酰基团。
• DIAMINOPYRIMIDINECARBOXA MIDE DERIVATIVE
  申请人：Astellas Pharma Inc.

  公开号：EP1518855B1

  公开（公告）日：2011-10-26
• 2-(4-nitrophenyl)oxirane amino derivatives in heterocyclization reactions
  作者：V. A. Pal’chikov

  DOI：10.1134/s1070428015080096

  日期：2015.8

  Reactions of 2-amino-1-(4-nitrophenyl)ethanol with various electrophilic reagents led to the formation of oxazaheterocycles (1,3-oxazolidin-2-one, 1,3-oxazolidine, morpholin-2-, -3-one, and -2,3-dione). In reactions of 2-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)amino}-1-(4-nitrophenyl)ethan-1-ol with carbonyldiimidazole, oxalyl chloride, benzaldehyde, and formaldehyde the corresponding derivatives of 1,3-oxazolidin-2- one, morpholin-2,3-dione, and 1,3-oxazolidine were obtained.