2-bromo-1,3-diethoxybenzene | 1435943-57-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-bromo-1,3-diethoxybenzene
• CAS: 1435943-57-9
• 化学式: C₁₀H₁₃BrO₂
• 分子量: 245.116
• InChiKey: CQSSOCJOZNFHIH-UHFFFAOYSA-N

物化性质

• 沸点：
  284.0±20.0 °C(Predicted)
• 密度：
  1.313±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,6-二乙氧基苯甲酸 在 silver carbonate 、 copper(ll) bromide 、 palladium dichloride 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以67%的产率得到2-bromo-1,3-diethoxybenzene
  参考文献：
  名称：

  Pd(II)-catalyzed bromo- and chlorodecarboxylation of electron-rich arenecarboxylic acids

  摘要：

  A bromo- and chlorodecarboxylation of various aromatic carboxylic acids catalyzed by Pd(II) has been developed in this work. A series of electron-rich arenecarboxylic acids gave the corresponding decarboxylative monohalogenation products under the typical reaction conditions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.03.135

文献信息

• NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS
  申请人：Jona Hideki

  公开号：US20110077262A1

  公开（公告）日：2011-03-31

  The invention relates to a compound of a general formula (I): wherein A represents a linking group; Ar 1 represents a group formed from an aromatic ring; R 1 and R 2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q 1 -N(R a )-Q 2 -R b ; a C1-C6 alkyl group optionally having substituent(s); an aryl or heterocyclic group optionally having substituent(s); or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom, a sulfur atom or an imino group. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.

  本发明涉及一种通式（I）的化合物：其中A代表连接基；Ar1代表由芳香环形成的基团；R1和R2各自独立地代表氢原子、卤原子、氰基、C2-C6烯基基团、C1-C6烷氧基团、卤代C1-C6烷氧基团、环-C3-C6烷氧基团、C2-C7烷酰基团、卤代C2-C7烷酰基团、C2-C7烷氧羰基团、卤代C2-C7烷氧羰基团、环-C3-C6烷氧羰基团、芳基烷氧羰基团、碳酰胺-C1-C6烷氧基团、羧基-C2-C6烯基基团或-Q1-N（Ra）-Q2-Rb基团；C1-C6烷基基团可选地具有取代基；芳基或杂环基团可选地具有取代基；或者C1-C6烷基或C2-C6烯基基团具有芳基或杂环基团；T和U各自独立地代表氮原子或甲基基团；V代表氧原子、硫原子或亚胺基团。本发明的化合物可用作治疗各种与ACC相关的疾病的治疗剂。
• US8524730B2
  申请人：——

  公开号：US8524730B2

  公开（公告）日：2013-09-03
• Pd(II)-catalyzed bromo- and chlorodecarboxylation of electron-rich arenecarboxylic acids
  作者：Xuefeng Peng、Xiang-Feng Shao、Zhong-Quan Liu

  DOI：10.1016/j.tetlet.2013.03.135

  日期：2013.6

  A bromo- and chlorodecarboxylation of various aromatic carboxylic acids catalyzed by Pd(II) has been developed in this work. A series of electron-rich arenecarboxylic acids gave the corresponding decarboxylative monohalogenation products under the typical reaction conditions. (C) 2013 Elsevier Ltd. All rights reserved.