5-[(4-chlorophenoxy)methyl]-5-oxo-1,3,2λ4,5λ5-dioxaselenaphosphinan-2-one | 1233542-12-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-[(4-chlorophenoxy)methyl]-5-oxo-1,3,2λ4,5λ5-dioxaselenaphosphinan-2-one
• 英文别名: 5-[(4-Chlorophenoxy)methyl]-1,3,2lambda4,5lambda5-dioxaselenaphosphinane 2,5-dioxide；5-[(4-chlorophenoxy)methyl]-1,3,2λ4,5λ5-dioxaselenaphosphinane 2,5-dioxide
• CAS: 1233542-12-5
• 化学式: C₉H₁₀ClO₅PSe
• 分子量: 343.562
• InChiKey: OIZCZRHXUYFOIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.42
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-(bromomethyl)-5-oxo-1,3,2λ4, 5λ5-dioxaselenaphosphinan-2-one 、 对氯苯酚 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以69%的产率得到5-[(4-chlorophenoxy)methyl]-5-oxo-1,3,2λ4,5λ5-dioxaselenaphosphinan-2-one
  参考文献：
  名称：

  Synthesis, Spectral Characterization and Antimicrobial Activity of Novel 5-[(Substituted Methyl]-5-oxo-1,3,2λ4,5λ5-dioxaselena Phosphinan-2-ones

  摘要：

  A series of novel 5-[(substituted) methyl]-5-oxo-1,3,2 lambda(4),5 lambda(5)-dioxa selenaphosphinan-2-ones (4-17) were successfully synthesized from tris(bromomethyl)phosphine oxide (I) and sodium selenite (2) to form the intermediate(3) which on further treatment with various alcohols/ thiols/ phenols/ aminoacid esters afforded the title compounds (4-17) and their structures were established by multinuclear NMR (H-1-, C-13- and P-31-) and mass spectral data. Their antimicrobial activity was evaluated and they exhibited promising antibacterial activity.

  DOI：

  10.3987/com-10-11910

文献信息

• Synthesis, Spectral Characterization and Antimicrobial Activity of Novel 5-[(Substituted Methyl]-5-oxo-1,3,2λ4,5λ5-dioxaselena Phosphinan-2-ones
  作者：C. Naga Raju、S. Subba Reddy、B. Satheesh Krishna、V. Koteswara Rao

  DOI：10.3987/com-10-11910

  日期：——

  A series of novel 5-[(substituted) methyl]-5-oxo-1,3,2 lambda(4),5 lambda(5)-dioxa selenaphosphinan-2-ones (4-17) were successfully synthesized from tris(bromomethyl)phosphine oxide (I) and sodium selenite (2) to form the intermediate(3) which on further treatment with various alcohols/ thiols/ phenols/ aminoacid esters afforded the title compounds (4-17) and their structures were established by multinuclear NMR (H-1-, C-13- and P-31-) and mass spectral data. Their antimicrobial activity was evaluated and they exhibited promising antibacterial activity.