4,6-dimethylpyridine-2,3-dicarbonitrile | 937647-32-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4,6-dimethylpyridine-2,3-dicarbonitrile
• CAS: 937647-32-0
• 化学式: C₉H₇N₃
• mdl: MFCD09837225
• 分子量: 157.175
• InChiKey: ZKOMGRFHCDOSFV-UHFFFAOYSA-N

物化性质

• 沸点：
  374.6±42.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  60.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-氟苯甲酰肼 、 4,6-dimethylpyridine-2,3-dicarbonitrile 在 甲醇 、 sodium 作用下， 反应 4.0h， 以52%的产率得到N'-(7-amino-2,4-dimethyl-5H-pyrrolo[3,4-b]pyridin-5-ylidene)-4-fluorobenzohydrazide
  参考文献：
  名称：

  4,6-Dimethylpyridine-2,3-dicarbonitrile and its reaction with N-acylhydrazines

  摘要：

  An efficient method has been developed for the synthesis of 4,6-dimethylpyridine-2,3-dicarbonitrile. A study was carried out on the reaction of this compound with N-acylhydrazines to give two structural isomers, namely, N'-(7-amino-2,4-dimethyl-5H-pyrrolo[3,4-b]pyridin-5-ylidene)carbohydrazides and N'-(5-amino-2,4-dimethyl-7H-pyrrolo[3,4-b]pyridin-7-ylidene)carbohydrazides as well as disubstituted N',N ''-(2,4-dimethyl-5H-pyrrolo[3,4-b]pyridine-5,7-diylidene)dicarbohydrazides.

  DOI：

  10.1007/s10593-011-0861-6
• 作为产物：
  描述：

  4,6-二甲基-3-氰基吡啶 在 间氯过氧苯甲酸 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 3.0h， 生成 4,6-dimethylpyridine-2,3-dicarbonitrile
  参考文献：
  名称：

  4,6-Dimethylpyridine-2,3-dicarbonitrile and its reaction with N-acylhydrazines

  摘要：

  An efficient method has been developed for the synthesis of 4,6-dimethylpyridine-2,3-dicarbonitrile. A study was carried out on the reaction of this compound with N-acylhydrazines to give two structural isomers, namely, N'-(7-amino-2,4-dimethyl-5H-pyrrolo[3,4-b]pyridin-5-ylidene)carbohydrazides and N'-(5-amino-2,4-dimethyl-7H-pyrrolo[3,4-b]pyridin-7-ylidene)carbohydrazides as well as disubstituted N',N ''-(2,4-dimethyl-5H-pyrrolo[3,4-b]pyridine-5,7-diylidene)dicarbohydrazides.

  DOI：

  10.1007/s10593-011-0861-6

文献信息

• 4,6-Dimethylpyridine-2,3-dicarbonitrile and its reaction with N-acylhydrazines
  作者：I. V. Rudenko、A. A. Kucherak、A. A. Tolmachev、O. V. Hordiyenko

  DOI：10.1007/s10593-011-0861-6

  日期：2011.11

  An efficient method has been developed for the synthesis of 4,6-dimethylpyridine-2,3-dicarbonitrile. A study was carried out on the reaction of this compound with N-acylhydrazines to give two structural isomers, namely, N'-(7-amino-2,4-dimethyl-5H-pyrrolo[3,4-b]pyridin-5-ylidene)carbohydrazides and N'-(5-amino-2,4-dimethyl-7H-pyrrolo[3,4-b]pyridin-7-ylidene)carbohydrazides as well as disubstituted N',N ''-(2,4-dimethyl-5H-pyrrolo[3,4-b]pyridine-5,7-diylidene)dicarbohydrazides.