3,3-[1,2-亚乙基二(硫代)]二-1-丙醇 | 4756-21-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 3,3-[1,2-亚乙基二(硫代)]二-1-丙醇
• 英文名称: 1,2-bis(3-hydroxypropylthio)ethane
• 英文别名: 4,7-dithiadeca-1,10-diol；1,12-Dioxa-5,8-dithiadodecan；3,3'-ethane-1,2-diylbissulfanyl-bis-propan-1-ol；4,7-dithia-decane-1,10-diol；1,2-Bis-(3-hydroxy-propylmercapto)-aethan；1,2-bis-(3-hydroxy-propylsulfanyl)-ethane；1-Propanol, 3,3'-[1,2-ethanediylbis(thio)]bis-；3-[2-(3-hydroxypropylsulfanyl)ethylsulfanyl]propan-1-ol
• CAS: 4756-21-2
• 化学式: C₈H₁₈O₂S₂
• mdl: MFCD19705232
• 分子量: 210.362
• InChiKey: GBZDOXLAUOJYPB-UHFFFAOYSA-N

物化性质

• 熔点：
  49-52 °C(Solv: benzene (71-43-2))
• 沸点：
  352.6±22.0 °C(Predicted)
• 密度：
  1.146±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  91.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,3-[1,2-亚乙基二(硫代)]二-1-丙醇 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 反应 1.0h， 以35%的产率得到1,2-bis(3-chloropropylthio)ethane
  参考文献：
  名称：

  Synthesis and properties of tetradentate distibine-diamine, distibine-dithioether and distibine-diether ligands

  摘要：

  DOI：

  10.1016/s0022-328x(00)83008-9
• 作为产物：
  描述：

  1,2-乙二硫醇 、 3-氯-1-丙醇 在 乙醇 、 sodium 作用下， 生成 3,3-[1,2-亚乙基二(硫代)]二-1-丙醇
  参考文献：
  名称：

  Synthesis and properties of tetradentate distibine-diamine, distibine-dithioether and distibine-diether ligands

  摘要：

  DOI：

  10.1016/s0022-328x(00)83008-9

文献信息

• Linear oligosulfoxides: Synthesis and solubility studies
  作者：Bhaskar Halami、Dhananjani N.A.M. Eriyagama、Komal Chillar、Zack Nelson、Lucas Prehoda、Yipeng Yin、Bao-Yuan Lu、Brett Otto、Liam Haggerty、Shiyue Fang

  DOI：10.1016/j.tetlet.2019.151306

  日期：2019.12

  found to have limited solubility in many solvents including DMSO and water, which disobeys the “like dissolves like” rule. The surprising solubility pattern of oligosulfoxides was discussed in the context of the drastically different solubility patterns of polyethylene glycol (PEG), poly(butylene oxide), and poly(methylene oxide). According to a dissolution model, solubility properties of linear oligomers

  通过多个S N合成三个含有多达六个亚砜基的线性低聚亚砜链烷硫醇和甲苯磺酸烷基酯之间的2个反应，得到线性低聚硫化物，然后用高碘酸钠氧化低聚硫化物，得到低聚亚砜。使用高碘酸钠氧化条件可以轻松克服完全避免部分氧化和过度氧化的挑战。尽管亚砜是一个高极性的官能团，但发现低聚亚砜在许多溶剂（包括DMSO和水）中的溶解度有限，这违反了“类似溶解”的规则。在聚乙二醇（PEG），聚（环氧丁烷）和聚（环氧丙烷）完全不同的溶解度模式的背景下，讨论了低聚亚砜的令人惊讶的溶解度模式。根据溶出度模型，线性低聚物（包括低聚亚砜和PEG）的溶解性可能会受到其构象及其构象在水中的适宜性的影响，以最大程度地提高它们与水之间的吸引力。基于这些假设，本发明的亚砜的有限的溶解度可能并不意味着相似分子的溶解度低。
• Method of developing silver halide photographic material
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04551419A1

  公开（公告）日：1985-11-05

  A silver halide photographic material which contains a light-sensitive silver halide emulsion and an internally fogged silver halide emulsion is development-processed in the presence of at least one compound selected from the group consisting of compounds represented by the general formulae (I) and (II) and at least one azaindene having a mercapto group to exhibit high photographic speed, high contrast and high maximum image density: R.sub.1 --(R.sub.3).sub.l X}.sub.n R.sub.3 '--R.sub.2 (I) wherein R.sub.1 and R.sub.2 each represents a hydrogen atom, an aryl group, an aryl group, or a heterocyclic group; R.sub.3 and R.sub.3 ' each represents an alkylene group, an arylene group, a heterocyclic group; X presents ##STR1## R.sub.4 represents a hydrogen atom or --R.sub.5 --Y}.sub.m R.sub.5 '--R.sub.6 ; R.sub.5 and R.sub.5 ' have the same meanings as R.sub.3 and R.sub.3 '; R.sub.6 has the same meaning as R.sub.1 and R.sub.2 ; Y represents ##STR2## R.sub.7 has the same meaning as R.sub.1 and R.sub.2 ; l represents 0 or 1, n represents an integer of 1 to 110, and m represents an integer of 0 to 10, and at least one X therein must be a sulfur atom: ##STR3## wherein Q represents atoms necessary to form a heterocyclic ring, and A represents an alkyl group, or an aryl group.

  一种含有感光银卤酸盐乳剂和内部雾化银卤酸盐乳剂的银卤酸盐摄影材料，在存在于通式（I）和（II）所表示的化合物组成的群体中至少选择一种化合物和至少一种带有巯基的氮杂吲哚的存在下进行显影处理，以表现出高摄影速度、高对比度和高最大图像密度： R.sub.1 --(R.sub.3).sub.l X}.sub.n R.sub.3 '--R.sub.2 (I) 其中，R.sub.1和R.sub.2分别表示氢原子、芳基、杂环基；R.sub.3和R.sub.3'分别表示烷基、芳基、杂环基；X表示##STR1##；R.sub.4表示氢原子或--R.sub.5 --Y}.sub.m R.sub.5 '--R.sub.6；R.sub.5和R.sub.5'的含义与R.sub.3和R.sub.3'相同；R.sub.6的含义与R.sub.1和R.sub.2相同；Y表示##STR2##；R.sub.7的含义与R.sub.1和R.sub.2相同；l表示0或1，n表示1到110的整数，m表示0到10的整数，并且其中至少有一个X是硫原子：##STR3## 其中，Q表示形成杂环环所必需的原子，A表示烷基或芳基。
• TIN ALLOY PLATING SOLUTION
  申请人：Mitsubishi Materials Corporation

  公开号：EP3835458A1

  公开（公告）日：2021-06-16

  A tin alloy plating solution includes a soluble tin salt, a soluble salt of a metal more noble than tin, and a sulfide compound represented by General Formula (1). In the General Formula (1), (A) is a hydrocarbon group including no oxygen atom and having 1 to 2 carbon atoms, or (A) is a hydrocarbon group including one or more oxygen atoms and having 2 to 6 carbon atoms. The metal which is more noble than tin is preferably silver, copper, gold or bismuth.

  锡合金电镀液包括一种可溶性锡盐、一种比锡更惰性的金属的可溶性盐和一种由通式（1）表示的硫化物化合物。在通式（1）中，(A)是不含氧原子且具有 1 至 2 个碳原子的烃基；或(A)是含有一个或多个氧原子且具有 2 至 6 个碳原子的烃基。比锡更惰性的金属最好是银、铜、金或铋。
• Tin alloy plating solution
  申请人：MITSUBISHI MATERIALS CORPORATION

  公开号：US11060200B2

  公开（公告）日：2021-07-13

  A tin alloy plating solution includes a soluble tin salt, a soluble salt of a metal more noble than tin, and a sulfide compound represented by General Formula (1). In the General Formula (1), (A) is a hydrocarbon group including no oxygen atom and having 1 to 2 carbon atoms, or (A) is a hydrocarbon group including one or more oxygen atoms and having 2 to 6 carbon atoms. The metal which is more noble than tin is preferably silver, copper, gold or bismuth.

  锡合金电镀液包括一种可溶性锡盐、一种比锡更惰性的金属的可溶性盐和一种由通式（1）表示的硫化物化合物。在通式（1）中，(A)是不含氧原子且具有 1 至 2 个碳原子的烃基；或(A)是含有一个或多个氧原子且具有 2 至 6 个碳原子的烃基。比锡更惰性的金属最好是银、铜、金或铋。
• M EASUREMENT OF P EDIATRIC I LLNESS S EVERITY U SING S IMPLE P RETRANSPORT V ARIABLES
  作者：Richard A. Orr、Shekhar T. Venkataraman、Karin A. McCloskey、Janine E. Janosky、Michelle Dragotta、Deborah Bills、William D. King

  DOI：10.1080/10903120190939986

  日期：2001.1

  Objective: To test the hypothesis that pretransport variables can predict in-hospital mortality that will correlate with major interventions and unplanned events during interfacility transport. Methods: A cohort of children (n = 2,253) transported by a specialized pediatric team to a children's hospital were studied. At the time of referral, data collected included age (months), heart rate, systolic blood pressure, respiratory rate, retractions, stridor or wheezing, seizures, skin perfusion, oxygen requirement, and mental status. Using univariate and stepwise logistic regression, variables predictive of in-hospital mortality were selected from a training set (n = 1,111) and assigned integers based on their computed coefficients. Probability of in-hospital mortality was calculated using the total integer score and age. The risk of mortality derived from the training set was validated in the remaining patients (n = 1,142) by comparing the observed and predicted mortalities. Major interventions performed and unplanned events were determined for each of five predetermined mortality risk groups. Results: Variables (integers) predicting in-hospital mortality included systolic blood pressure (11), respiratory rate (6), oxygen requirement (11), and altered mental status (11). Observed mortality was similar to predicted mortality in all risk categories for the validation sample. As risk of mortality increased, so did the performance of major interventions and the occurrence of unplanned events. Conclusion: Four pretransport variables predicted in-hospital mortality. Risk of mortality correlated with the incidence of major patient interventions, and the occurrence of unplanned events increased as well. This model might be useful in comparing different transport systems using severity-adjusted assessment of children requiring interfacility transport.