Tetramethylcysteamin | 342613-81-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醇
• 英文名称: Tetramethylcysteamin
• 英文别名: 3-amino-2,3-dimethylbutane-2-thiol
• CAS: 342613-81-4
• 化学式: C₆H₁₅NS
• mdl: MFCD19209485
• 分子量: 133.26
• InChiKey: QUUIRAXZSRTMOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,2,3,3-四甲基氮丙啶 、 硫化氢 以48%的产率得到
  参考文献：
  名称：

  YAMAGUCHI HACHIRO; ARITA YUJI, XIROSIMA DAJGAKU KOGAKUBU KEHNKYU XOKOKU, BULL. FAS. ENG. HIROSHIMA UNIV.+

  摘要：

  DOI：

文献信息

• Permanent waving composition
  申请人：SEIWA KASEI CO., LTD.

  公开号：EP0361391A2

  公开（公告）日：1990-04-04

  An aqueous permanent waving composition containing as a reducing agent a quaternary ammoniomercaptan or its salt of the formula: wherein R¹, R², and R³ are an alkyl group or a hydroxyalkyl group, A is an alkylene group, and X is a halogen atom, NO₃, ½SO₄, OH or R⁴OSO₃ in which R⁴ is an alkyl group, which can be used under an acidic, neutral or alkaline condition and can impart good waves to hairs with a little damage of the hairs and a little foul smell.

  一种含水的永久性挥发组合物，其还原剂是式中的季铵盐或其盐： 其中 R¹、R² 和 R³ 是烷基或羟烷基，A 是亚烷基，X 是卤素原子、NO₃、1/2SO₄、OH 或 R⁴OSO₃，其中 R⁴ 是烷基，该组合物可在酸性、中性或碱性条件下使用，能给头发带来良好的波纹，对头发的损伤小，气味小。
• Porous resin particle having hydroxy group or primary amino group and production method thereof
  申请人：Nitto Denko Corporation

  公开号：EP2055723A1

  公开（公告）日：2009-05-06

  The present invention relates to a method for producing a porous resin particle having a functional group X, the method including: dissolving a radical polymerizable aromatic monovinyl monomer and a radical polymerizable aromatic divinyl monomer together with a polymerization initiator in an organic solvent to prepare a monomer solution, dispersing the monomer solution in water in the presence of a dispersion stabilizer to obtain a suspension polymerization reaction mixture, and performing a suspension copolymerization while adding, when 0 to 80% of the entire polymerization time of the suspension copolymerization is passed, a mercapto compound represented by the formula (I):          HS-R-X     (I) in which R represents an alkylene group having a carbon number of 2 to 12, and the functional group X represents a functional group selected from a hydroxy group and a primary amino group, to the suspension polymerization reaction mixture; and the porous resin particle obtained by the method.

  本发明涉及一种生产具有官能团 X 的多孔树脂颗粒的方法，该方法包括：将可自由基聚合的芳香族单乙烯基单体和可自由基聚合的芳香族二乙烯基单体与聚合引发剂一起溶解在有机溶剂中，制备单体溶液；在有分散稳定剂存在的情况下，将单体溶液分散在水中，得到悬浮聚合反应混合物；进行悬浮共聚，同时在悬浮共聚整个聚合时间的 0 至 80% 时，加入由式 (I) 表示的巯基化合物： HS-R-X (I) 其中 R 代表碳数为 2 至 12 的亚烷基，官能团 X 代表选自羟基和伯氨基的官能团；以及通过该方法获得的多孔 树脂颗粒。
• EXTENDED RELEASE CONJUGATES OF EXENATIDE ANALOGS
  申请人：Prolynx LLC

  公开号：EP3922269A1

  公开（公告）日：2021-12-15

  Extended-release conjugates of stabilized GLP-1 agonists balance agonist stability with release rates to provide long lasting administration to treat diabetes and related conditions on once-a-month or less frequent dosing schedules.

  稳定型 GLP-1 激动剂的缓释共轭物兼顾了激动剂的稳定性和释放率，可通过每月一次或更少次数的给药计划提供长效给药，治疗糖尿病和相关疾病。
• Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof
  申请人：SANOFI

  公开号：US11214541B2

  公开（公告）日：2022-01-04

  Compounds of formula (I): wherein R1 and R2 represent hydrogen or deuterium atoms; R3 represents a hydrogen atom or a —COOH, a —OH or a —OPO(OH)2 group; R4 represents a hydrogen atom or a fluorine atom; R5 represents a hydrogen atom or a —OH group; wherein at least one of R3 or R5 is different from a hydrogen atom; when R3 represents a —COOH, —OH or —OPO(OH)2 group, then R5 represents a hydrogen atom; when R5 represents a —OH group, then R3 and R4 represent hydrogen atoms; and R6 is selected from an optionally substituted phenyl, heteroaryl, cycloalkyl and heterocycloalkyl group; and the preparation and the therapeutic uses of the compounds of formula (I) as inhibitors and degraders of estrogen receptors, useful especially in the treatment of cancer.

  式(I)化合物： 其中 R1 和 R2 代表氢原子或氘原子；R3 代表氢原子或-COOH、-OH 或-OPO(OH)2 基团；R4 代表氢原子或氟原子；R5 代表氢原子或-OH 基团；其中 R3 或 R5 中至少有一个不同于氢原子；当 R3 代表-COOH、-OH 或-OPO(OH)2 基团时，则 R5 代表氢原子；当 R5 代表-OH 基团时，则 R3 和 R4 代表氢原子；以及 R6 选自任选取代的苯基、杂芳基、环烷基和杂环烷基； 以及式（I）化合物作为雌激素受体抑制剂和降解剂的制备和治疗用途，特别是在癌症治疗中的用途。
• YAMAGUCHI HACHIRO; ARITA YUJI, XIROSIMA DAJGAKU KOGAKUBU KEHNKYU XOKOKU, BULL. FAS. ENG. HIROSHIMA UNIV.+
  作者：YAMAGUCHI HACHIRO、 ARITA YUJI

  DOI：——

  日期：——