3,4,5,6,7,8-六氢苯并-2,9-二氧杂环十二碳六烯-1,10-二酮 | 16709-50-5

• 分子结构分类: 有机化合物 - 苯类化合物
• 中文名称: 3,4,5,6,7,8-六氢苯并-2,9-二氧杂环十二碳六烯-1,10-二酮
• 英文名称: 3,4,5,6,7,8-hexahydrobenzo[c][1,6]dioxacyclododecine-1,10-dione
• 英文别名: 3,4,5,6,7,8-hexahydrobenzo-2,9-dioxacyclododecin-1,10-dione；2,9-Benzodioxacyclododecin-1,10-dione, 3,4,5,6,7,8-hexahydro-；3,10-dioxabicyclo[10.4.0]hexadeca-1(16),12,14-triene-2,11-dione
• CAS: 16709-50-5
• 化学式: C₁₄H₁₆O₄
• 分子量: 248.279
• InChiKey: DGMTZMCDDBNVPU-UHFFFAOYSA-N

物化性质

• 沸点：
  478.7±28.0 °C(Predicted)
• 密度：
  1.140±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2932999099

反应信息

• 作为产物：
  描述：

  Phthalic acid mono-(6-iodo-hexyl) ester 在 silver tetrafluoroborate 、 caesium carbonate 作用下， 以 丙酮 为溶剂， 反应 12.0h， 生成 3,4,5,6,7,8-六氢苯并-2,9-二氧杂环十二碳六烯-1,10-二酮
  参考文献：
  名称：

  Synthesis of macrocyclic dilactones by cyclization of sulfonium salts

  摘要：

  An efficient method for the formation of macrocyclic dilactones via cyclization of (omega-carboxyalkyl)diphenylsulfonium salts 3 containing an ester linkage under mild conditions is described. These sulfonium salts 3 were cyclized in the presence of cesium carbonate under high-dilution conditions to give 11- to 16-membered dilactones 4 in good yields. The cyclization of sulfonium salt 22 was successfully carried out for the synthesis of 11-membered dilactonic pyrrolizidine alkaloid, 13,13-dimethyl-1,2-didehydrocrotalanine 23.

  DOI：

  10.1021/jo00040a013

文献信息

• Silver carboxylate promoted lactonization: a general method applicable to prepare medium and large-sized lactones without high dilution or slow addition
  作者：Le Liu、Shimin Xu、Hongwei Zhou

  DOI：10.1016/j.tet.2013.07.064

  日期：2013.9

  and simple operation, remains a challenging task for the organic community. We developed a ‘freshman-can-do’ protocol to medium- and large-sized lactones, not depending on high-dilution or slow addition techniques. Application of this method for the synthesis of natural lactones or potentially pharmaceutical compounds might be useful for organic chemists and pharmacists.

  对于有机内酯而言，有效且适用的宏观内酯化方法以及充足的起始原料和简单的操作方法仍然是一项艰巨的任务。我们为中型和大型内酯开发了“新鲜人可以做”的实验方案，而不依赖于高稀释或慢速添加技术。该方法用于天然内酯或潜在药物化合物的合成对于有机化学家和药剂师可能是有用的。
• Coating composition and floor covering including the composition
  申请人：Armstrong World Industries, Inc.

  公开号：EP0783008A2

  公开（公告）日：1997-07-09

  Floor coverings include a wear layer made from a coat composition including a multifunctional polyurethane (meth)acrylate oligomer. The multifunctional polyurethane is made by reacting a polyisocyanate with a functionality equal or higher than 3, a polyester polyol, and a hydroxyalkyl-(meth)acrylate with a molecular weight of about 116 to about 600. The coating composition preferably includes a reactive (meth)acrylate diluent and a photoinitiator.

  地板覆盖层包括由包括多功能聚氨酯（甲基）丙烯酸酯低聚物的涂层组合物制成的耐磨层。多功能聚氨酯是由官能度等于或大于 3 的多异氰酸酯、聚酯多元醇和分子量约为 116 至 600 的羟烷基-（甲基）丙烯酸酯反应而成。涂料组合物最好包括活性（甲基）丙烯酸酯稀释剂和光引发剂。
• FLOOR COATINGS COMPRISING A RESIN, A CURE SYSTEM AND DIAMOND PARTICLES AND METHODS OF MAKING THE SAME
  申请人：AFI Licensing LLC

  公开号：EP3523386A1

  公开（公告）日：2019-08-14
• US5003026A
  申请人：——

  公开号：US5003026A

  公开（公告）日：1991-03-26
• US5719227A
  申请人：——

  公开号：US5719227A

  公开（公告）日：1998-02-17