1,2,3,4-Tetrahydropyrido<3,2-c>pyridazin | 69142-91-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1,2,3,4-Tetrahydropyrido<3,2-c>pyridazin
• 英文别名: 1,2,3,4-tetrahydro-pyrido[3,2-c]pyridazine；1,2,3,4-Tetrahydropyrido[3,2-c]pyridazine
• CAS: 69142-91-2
• 化学式: C₇H₉N₃
• 分子量: 135.169
• InChiKey: DAVSUECJZIRNDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  37
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2,3,4-Tetrahydropyrido<3,2-c>pyridazin 、 氧化汞(II)红 、 氧气 以37%的产率得到
  参考文献：
  名称：

  JONES G.; RAFFERTY P., TETRAHEDRON LETT., 1978, NO 30, 2731-2734

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4-dihydro-pyrido[3,2-c]pyridazine-1,2-dicarboxylic acid di-tert-butyl ester 、 三氟乙酸 以94%的产率得到
  参考文献：
  名称：

  JONES G.; RAFFERTY P., TETRAHEDRON LETT., 1978, NO 30, 2731-2734

  摘要：

  DOI：

文献信息

• PROCESS FOR PREPARING A COMPOUND BY A NOVEL SANDMEYER-LIKE REACTION USING A NITROXIDE RADICAL COMPOUND AS A REACTION CATALYST
  申请人：DAIICHI SANKYO COMPANY, LIMITED

  公开号：US20130144061A1

  公开（公告）日：2013-06-06

  The present invention provides a novel process for preparing a substituted aromatic compound such as an aromatic halo compound or a salt thereof through a transformation reaction of an aromatic diazonium salt from an aromatic amino compound at stable high yields utilizing a novel Sandmeyer-like reaction using a nitroxide radical compound as a reaction catalyst.

  本发明提供了一种新型方法，通过使用一种新型的桑迷尔反应，利用一种亚硝基自由基化合物作为反应催化剂，从芳香氨基化合物的芳香重氮盐进行转化反应，以稳定高产率制备取代芳香化合物，如芳香卤素化合物或其盐。
• 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
  申请人：Ashton T Wallace

  公开号：US20060074087A1

  公开（公告）日：2006-04-06

  The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及3-氨基-4-苯基丁酸衍生物，它们是二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂，可用于治疗或预防二肽基肽酶-IV酶涉及的疾病，如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗二肽基肽酶-IV酶涉及的这些疾病中使用这些化合物和组合物。
• NOVEL FUSED PYROLE DERIVATIVE
  申请人：Sone Toshihiko

  公开号：US20100190768A1

  公开（公告）日：2010-07-29

  The present invention relates to a compound represented by the formula (1) which is useful as a glucocorticoid receptor function regulating agent, an anti-inflammatory agent or an antidiabetic agent, or a pharmaceutically acceptable salt thereof: wherein R 1 is aralkyl, etc.; R 2 is H, etc.; —W 4 ═W 5 —W 6 ═W 7 — is a group of the formula: —CR 4 ═CR 5 —CR 6 ═CR 7 — (in which R 4 , R 5 , R 6 and R 7 are independently a group of the formula: -E-A (E is a single bond, etc., A is H or nitro, etc.)), etc.; R 8 is a group of the formula: —OR 11 (R 11 is H, etc.), etc.; R 9 is trifluoromethyl, etc.; R 10 is a group of the formula: —[C(R 13 )(R 14 )] n —R 15 (R 13 and R 14 are independently H, etc., n is an integer of 0 to 10, R 15 is a group of the formula: N(R 18 )R 19 (R 18 and R 19 form a nitrogen-containing heteromonocycle together with a nitrogen atom to which they are bonded), etc.).

  本发明涉及一种化合物，其化学式为(1)，它可作为糖皮质激素受体功能调节剂、抗炎剂或抗糖尿病剂，或其药学上可接受的盐使用：其中R1为芳基烷基等；R2为H等；-W4═W5-W6═W7-为以下式的基团：-CR4═CR5-CR6═CR7-(其中R4、R5、R6和R7独立地为以下式的基团：-E-A(E为单键等，A为H或硝基等))等；R8为以下式的基团：-OR11(R11为H等)等；R9为三氟甲基等；R10为以下式的基团：-[C(R13)(R14)]n-R15(R13和R14独立地为H等，n为0到10的整数，R15为以下式的基团：N(R18)R19(R18和R19与它们连接的氮原子一起形成含氮杂单环)等。
• NOVEL FUSED PYRROLE DERIVATIVE
  申请人：Dainippon Sumitomo Pharma Co., Ltd.

  公开号：EP1930320A1

  公开（公告）日：2008-06-11

  The present invention relates to a compound represented by the formula (1) which is useful as a glucocorticoid receptor function regulating agent, an anti-inflammatory agent or an antidiabetic agent, or a pharmaceutically acceptable salt thereof: wherein R1 is aralkyl, etc.; R2 is H, etc.; -W4=W5-W6=W7- is a group of the formula: -CR4=CR5-CR6=CR7- (in which R4, R5, R6 and R7 are independently a group of the formula: -E-A (E is a single bond, etc., A is H or nitro, etc.)), etc.; R8 is a group of the formula: -OR11 (R11 is H, etc.), etc.; R9 is trifluoromethyl, etc.; R10 is a group of the formula: -[C(R13)(R14)]n-R15 (R13 and R14 are independently H, etc., n is an integer of 0 to 10, R15 is a group of the formula: N(R18)R19 (R18 and R19 form a nitrogen-containing heteromonocycle together with a nitrogen atom to which they are bonded), etc.).

  本发明涉及一种由式（1）表示的化合物，它可用作糖皮质激素受体功能调节剂、抗炎剂或抗糖尿病剂，或其药学上可接受的盐： 其中 R1 是芳烷基等；R2 是 H 等；-W4=W5-W6=W7- 是式中的基团：-CR4=CR5-CR6=CR7-（其中 R4、R5、R6 和 R7 独立地是式子中的一个基团：-E-A（E 是单键等，A 是 H 或硝基等））等； R8 是式中的基团：-OR11（R11 是 H 等）等； R9 是三氟甲基等； R10 是式中的基团：-[C(R13)(R14)]n-R15（R13 和 R14 独立地为 H 等，n 为 0 至 10 的整数，R15 为式中的基团：N(R18)R19（R18 和 R19 与它们键合的氮原子一起形成含氮杂单环）等）。
• PROCESS FOR PREPARING COMPOUND BY NOVEL SANDMEYER-LIKE REACTION USING NITROXIDE RADICAL COMPOUND AS REACTION CATALYST
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2602242A1

  公开（公告）日：2013-06-12

  The present invention provides a novel process for preparing a substituted aromatic compound such as an aromatic halo compound or a salt thereof through a transformation reaction of an aromatic diazonium salt from an aromatic amino compound at stable high yields utilizing a novel Sandmeyer-like reaction using a nitroxide radical compound as a reaction catalyst.

  本发明提供了一种新工艺，利用一种新型桑德迈尔类反应，以硝基自由基化合物为反应催化剂，通过芳香族重氮盐与芳香族氨基化合物的转化反应，以稳定的高产率制备取代的芳香族化合物，如芳香族卤代化合物或其盐。