2,3-bis(dodecyloxy)propan-1-ol | 17677-18-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 2,3-bis(dodecyloxy)propan-1-ol
• 英文别名: 2,3-didodecyloxypropan-1-ol；1,2-Di-O-dodecylglycerol；2,3-bis-dodecyloxy-propan-1-ol；1,2-O-dilaurylglycerol；1,2-dilaurylglycerol；1,2-Di-O-dodecyl-rac-glycerol；2,3-didodecoxypropan-1-ol
• CAS: 17677-18-8
• 化学式: C₂₇H₅₆O₃
• 分子量: 428.74
• InChiKey: XZBACIYYJPQCJG-UHFFFAOYSA-N

物化性质

• 熔点：
  38 °C
• 沸点：
  520.6±30.0 °C(Predicted)
• 密度：
  0.884±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  30
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,3-bis(dodecyloxy)propan-1-ol 在 palladium on activated charcoal 、 碳酸氢钠 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl 、 sodium hypochlorite 、 氢气 、 三氟乙酸 、 sodium bromide 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 水 、 乙酸乙酯 、 甲苯 为溶剂， 反应 26.42h， 生成 4,5-bis(dodecyloxy)pentanoic acid
  参考文献：
  名称：

  Synthesis of Lipophilic Aldehydes and Study of Their Inhibition Effect on Human Digestive Lipases

  摘要：

  [GRAPHICS]Novel inhibitors of human digestive lipases, aldehyde dialkyl and alkyl-acyl glycerol analogues, were developed. The inhibitors were prepared starting from 3-(benzyloxy)-1,2-propanediol. The inhibition of human pancreatic and gastric lipases by the aldehyde derivatives was studied using the monolayer technique. (1R)-1-[(Dodecyloxy)methyl]-4-oxobutyl decanoate caused a 50% decrease in HPL and HGL activities at 0.100 and 0.053 molar fractions, respectively.

  DOI：

  10.1021/ol026039l
• 作为产物：
  描述：

  3-OBn-1,2-dilaurylglycerol 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以75%的产率得到2,3-bis(dodecyloxy)propan-1-ol
  参考文献：
  名称：

  Synthesis of Lipophilic Aldehydes and Study of Their Inhibition Effect on Human Digestive Lipases

  摘要：

  [GRAPHICS]Novel inhibitors of human digestive lipases, aldehyde dialkyl and alkyl-acyl glycerol analogues, were developed. The inhibitors were prepared starting from 3-(benzyloxy)-1,2-propanediol. The inhibition of human pancreatic and gastric lipases by the aldehyde derivatives was studied using the monolayer technique. (1R)-1-[(Dodecyloxy)methyl]-4-oxobutyl decanoate caused a 50% decrease in HPL and HGL activities at 0.100 and 0.053 molar fractions, respectively.

  DOI：

  10.1021/ol026039l

文献信息

• [EN] LEPTIN mRNA COMPOSITIONS AND FORMULATIONS<br/>[FR] COMPOSITIONS ET FORMULATIONS D'ARNM DE LA LEPTINE
  申请人：NOVARTIS AG

  公开号：WO2015095351A1

  公开（公告）日：2015-06-25

  A formulation comprising a modified synthetic messenger RNA and a delivery agent. The modified synthetic messenger RNA encodes a leptin protein, is non-replicating and is translation-ready. The formulation can be delivered to a subject with congenital leptin deficiency, lipodystrophy or other condition where circulating leptin level is low.

  一种包含改良合成信使RNA和传递剂的配方。改良的合成信使RNA编码一个瘦素蛋白，不复制且准备好进行翻译。该配方可用于传递给患有先天性瘦素缺乏症、脂肪代谢障碍或其他循环瘦素水平低的病人。
• POLYGLYCERIN DIALKYL OR ALKENYL ETHER, AND COSMETIC COMPOSITION CONTAINING SAME
  申请人：Daicel Corporation

  公开号：EP2813483A1

  公开（公告）日：2014-12-17

  Provided are: a novel polyglycerol di-(alkyl/alkenyl) ether that is useful as a highly hydrophilic gemini surfactant; and a cosmetic composition containing the polyglycerol di-(alkyl/alkenyl) ether. The polyglycerol di-(alkyl/alkenyl) ether is represented by Formula (1), where R1 and R2 are identical or different and are independently a straight- or branched-chain alkyl group or a straight- or branched-chain alkenyl group, where the alkyl group may have one or more hydroxyl groups; and n indicates a number of glycerol units and is an integer of 2 or more. Formula (1) is expressed as follows:

  提供了一种新型聚甘油二-(烷基/烯基)醚，可用作高度亲水的双子表面活性剂；以及含有该聚甘油二-(烷基/烯基)醚的化妆品组合物。聚甘油二-(烷基/烯基)醚由化学式(1)表示，其中R1和R2相同或不同，独立地表示直链或支链烷基或直链或支链烯基，其中烷基可能具有一个或多个羟基；n表示甘油单元的数量，是大于等于2的整数。化学式(1)表达如下：
• [EN] RELEASABLE CATIONIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEMS<br/>[FR] LIPIDES CATIONIQUES LIBÉRABLES POUR SYSTÈMES D'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：ENZON PHARMACEUTICALS INC

  公开号：WO2010057155A1

  公开（公告）日：2010-05-20

  The present invention is directed to releasable cationic lipids and nanoparticle compositions for the delivery of nucleic acids and methods of modulating an expression of a target gene using the same. In particular, the invention relates to cationic lipids including an acid labile linker, and nanoparticle compositions containing the same.

  本发明涉及可释放的阳离子脂质和纳米颗粒组合物，用于传递核酸并利用其调节靶基因的表达的方法。具体而言，本发明涉及包含酸敏感连接剂的阳离子脂质和含有该连接剂的纳米颗粒组合物。
• CATIONIC AMPHIPILE COMPOSITIONS FOR INTERACELLUAR DELIVERY OF THERAPEUTIC MOLECULES
  申请人：——

  公开号：US20020013282A1

  公开（公告）日：2002-01-31

  Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. By this invention, such cationic amphiphile is used in a state in which it is capable of accepting additional protons, i.e., it is not fully protonated. For purposes of this invention, cationic amphiphiles may be considered to encompass four general categories: (A) T-shaped/steroid-based amphiphiles; (B) T-shaped/non steroid-based amphiphiles; (C) non T-shaped/steroid based amphiphiles and (D) non T-shaped/non steroid-based amphiphiles.

  提供了新型阳离子两性分子，可促进生物活性（治疗）分子进入细胞。通过这项发明，这种阳离子两性分子在能够接受额外质子的状态下使用，即它没有完全质子化。为了这项发明的目的，阳离子两性分子可以被认为包括四个一般类别：（A）T形/类固醇基两性分子；（B）T形/非类固醇基两性分子；（C）非T形/类固醇基两性分子和（D）非T形/非类固醇基两性分子。
• LIPID ENCAPSULATED INTERFERING RNA
  申请人：MacLachlan Ian

  公开号：US20060240093A1

  公开（公告）日：2006-10-26

  The present invention provides compositions and methods for silencing gene expression by delivering nucleic acid-lipid particles comprising a siRNA molecule to a cell.

  本发明提供了一种通过将含有siRNA分子的核酸-脂质粒子传递到细胞中，来沉默基因表达的组合物和方法。