1-cyclohexyl-2-(2,4,6-trimethoxyphenyl)ethanone | 1123575-16-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-cyclohexyl-2-(2,4,6-trimethoxyphenyl)ethanone
• 英文别名: 1-Cyclohexyl-2-(2,4,6-trimethoxyphenyl)ethanone
• CAS: 1123575-16-5
• 化学式: C₁₇H₂₄O₄
• 分子量: 292.375
• InChiKey: FOIIWTMDAVWVIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-cyclohexyl-2-(2,4,6-trimethoxyphenyl)ethanone 在 三溴化硼 作用下， 以 乙酸乙酯 为溶剂， 以80%的产率得到2-cyclohexyl-4,6-dimethoxybenzofuran
  参考文献：
  名称：

  DABCO-catalyzed formation of 4-methoxy-1,3-dioxolan-2-ones and their synthetic applications in the aromatic electrophilic substitution

  摘要：

  DABCO is a very effective catalyst in the formation of 4-methoxy-1,3-dioxolan-2-ones 10 from the corresponding alpha-carbonatoaldehydes 8 intermediates. The Friedel-Crafts reaction pathway of the cyclic carbonate 10 is dependent on the electron density of the aromatic nucleophiles. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.09.173
• 作为产物：
  描述：

  1,3,5-三甲氧基苯 、 4-cyclohexyl-5-methoxy-1,3-dioxolan-2-one 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 以83%的产率得到1-cyclohexyl-2-(2,4,6-trimethoxyphenyl)ethanone
  参考文献：
  名称：

  DABCO-catalyzed formation of 4-methoxy-1,3-dioxolan-2-ones and their synthetic applications in the aromatic electrophilic substitution

  摘要：

  DABCO is a very effective catalyst in the formation of 4-methoxy-1,3-dioxolan-2-ones 10 from the corresponding alpha-carbonatoaldehydes 8 intermediates. The Friedel-Crafts reaction pathway of the cyclic carbonate 10 is dependent on the electron density of the aromatic nucleophiles. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.09.173

文献信息

• DABCO-catalyzed formation of 4-methoxy-1,3-dioxolan-2-ones and their synthetic applications in the aromatic electrophilic substitution
  作者：Yung-Son Hon、Chen-Yi Kao

  DOI：10.1016/j.tetlet.2008.09.173

  日期：2009.2

  DABCO is a very effective catalyst in the formation of 4-methoxy-1,3-dioxolan-2-ones 10 from the corresponding alpha-carbonatoaldehydes 8 intermediates. The Friedel-Crafts reaction pathway of the cyclic carbonate 10 is dependent on the electron density of the aromatic nucleophiles. (C) 2008 Elsevier Ltd. All rights reserved.