1-(Benzenesulfonyl)-3-[(4-methoxyphenyl)methyl]indole | 1301740-47-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(Benzenesulfonyl)-3-[(4-methoxyphenyl)methyl]indole
• 英文别名: 1-(benzenesulfonyl)-3-[(4-methoxyphenyl)methyl]indole
• CAS: 1301740-47-5
• 化学式: C₂₂H₁₉NO₃S
• 分子量: 377.464
• InChiKey: PBVGCNOSQDWKEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  56.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-苯磺酸吲哚 、 4-甲氧基苄基乙酸酯 在 三氟甲磺酸 作用下， 反应 0.17h， 以95%的产率得到1-(Benzenesulfonyl)-3-[(4-methoxyphenyl)methyl]indole
  参考文献：
  名称：

  Brönsted acid-catalyzed synthesis of diarylmethanes under non-genotoxic conditions

  摘要：

  Triflic acid and triflimide were found to efficiently catalyze the formation of a wide diversity of diarylmethanes from the non-genotoxic benzylic acetates and electron-rich arenes or heteroarenes. The reaction worked best with acetates capable of generating a stabilized benzylic cationic species. In most cases, the reactions were conveniently run in the absence of solvent under mild conditions. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.033

文献信息

• Brönsted acid-catalyzed synthesis of diarylmethanes under non-genotoxic conditions
  作者：Oscar Mendoza、Guy Rossey、Léon Ghosez

  DOI：10.1016/j.tetlet.2011.01.033

  日期：2011.4

  Triflic acid and triflimide were found to efficiently catalyze the formation of a wide diversity of diarylmethanes from the non-genotoxic benzylic acetates and electron-rich arenes or heteroarenes. The reaction worked best with acetates capable of generating a stabilized benzylic cationic species. In most cases, the reactions were conveniently run in the absence of solvent under mild conditions. (C) 2011 Elsevier Ltd. All rights reserved.