3,4-二氯-1-(2,6-二乙基-苯基)-吡咯-2,5-二酮 | 56746-18-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 中文名称: 3,4-二氯-1-(2,6-二乙基-苯基)-吡咯-2,5-二酮
• 英文名称: N-(2,6-diethylphenyl)-3,4-dichloromaleimide
• 英文别名: 2,3-Dichloro-n-(2',6'-diethylphenyl)maleimide；3,4-dichloro-1-(2,6-diethylphenyl)pyrrole-2,5-dione
• CAS: 56746-18-0
• 化学式: C₁₄H₁₃Cl₂NO₂
• 分子量: 298.169
• InChiKey: ORINIFVNZFZTBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,3-二氯马来酸酐 、 2,6-二乙基苯胺 在 溶剂黄146 作用下， 以87.3%的产率得到3,4-二氯-1-(2,6-二乙基-苯基)-吡咯-2,5-二酮
  参考文献：
  名称：

  一系列马来酰亚胺的抗Leishmanial和细胞毒活性：合成，生物学评估和结构活性关系。

  摘要：

  在本研究中，已经合成了45种马来酰亚胺，并评估了其对体外杜氏乳酸杆菌的抗利什曼活性和对THP1细胞的细胞毒性。所有化合物均表现出明显的抗利什曼活性。在所测试的化合物中，有10种具有比标准药物两性霉素B更高的抗利什曼活性的马来酰亚胺，和32种具有比标准药物戊tam具有更好的抗利什曼活性的马来酰亚胺，尤其是化合物16（IC50 <0.0128μg/ mL）和42（IC50 <0.0128μg/ mL），在体外测试中显示出非凡的功效，并且细胞毒性低（CC50> 10μg/ mL）。16和42的抗Leishmanial活性比两性霉素B强10倍。结构和活性关系（SAR）研究表明，3，与3-甲基-马来酰亚胺和3,4-二氯-马来酰亚胺相比，4-未取代的马来酰亚胺显示出最强的抗利什曼活性。与3-甲基-马来酰亚胺和3,4-非取代的马来酰亚胺相比，3,4-二氯-马来酰亚胺的细胞毒性最小。结果表明，一些已报道的

  DOI：

  10.3390/molecules23112878

文献信息

• ANTIFOULING COATING COMPOSITION, ANTIFOULING COATING FILM FORMED USING SAID COMPOSITION, AND COATED ARTICLE HAVING ANTIFOULING COATING FILM ON SURFACE
  申请人：NITTO KASEI CO., LTD.

  公开号：US20160009925A1

  公开（公告）日：2016-01-14

  The present invention provides antifouling coating compositions having excellent long-term storage stability and provides an antifouling coating composition that can maintain the stable dissolution and antifouling performance of a coating film without causing coating film defects such as cracks in seawater for a long term, such that an antifouling coating film having increased environmental safety can be formed. The present invention provides an antifouling coating composition containing: (A) a triorganosilyl ester-containing copolymer obtained from a mixture of (a) a triorganosilyl(meth)acrylate monomer represented by general formula (1): (here, R 1 is a hydrogen atom or a methyl group; and R 2 , R 3 , and R 4 are the same or different from each other and each represents a C 3-6 alkyl group branched at the α-position or a phenyl group) and (b) an ethylenically unsaturated monomer copolymerizable with the triorganosilyl(meth)acrylate monomer; and (B) calcium sulfate hydrate.

  本发明提供了具有良好长期储存稳定性的防污涂层组合物，并提供了一种防污涂层组合物，该组合物可以在海水中长期维持涂层膜的稳定溶解和防污性能，而不会导致涂层膜出现裂纹等涂层膜缺陷，从而可以形成具有增加环境安全性的防污涂层膜。本发明提供了一种防污涂层组合物，包含：（A）从（a）通式（1）所表示的三有机硅酸酯单体（其中，R1为氢原子或甲基基；R2、R3和R4相同或不同，分别表示在α位分支的C3-6烷基或苯基）和（b）与三有机硅酸酯（甲基）丙烯酸酯单体共聚的乙烯基不饱和单体的混合物中获得的含三有机硅酸酯酯基的共聚物；以及（B）硫酸钙水合物。
• ANTIFOULING PAINT COMPOSITION, COPOLYMER FOR ANTIFOULING PAINT COMPOSITION AND METHOD FOR MANUFACTURING SAME, AND PAINTED OBJECT HAVING ON SURFACE ANTIFOULING PAINT FILM FORMED USING SAID COMPOSITION
  申请人：NITTO KASEI CO., LTD.

  公开号：US20160068688A1

  公开（公告）日：2016-03-10

  The purpose of the present invention is to provide a copolymer allowing for an antifouling coating composition used for the formation of an environment-friendly antifouling coating film. The antifouling coating composition gives the coating film increased water resistance and can maintain the stable dissolution property and antifouling performance of the coating film without causing coating film defects such as a crack during long-term seawater treatment. An aspect of the present invention provides a copolymer for an antifouling coating composition, including a copolymer (A) having, on a side chain, a group represented by chemical formula (1) and having, on terminal, at least one of a group represented by chemical formula (2) and a group represented by chemical formula (3).

  本发明的目的是提供一种共聚物，用于形成环保防污涂层膜的防污涂层组合物。该防污涂层组合物可以增加涂层膜的耐水性，并且可以在长期海水处理过程中保持涂层膜的稳定溶解性和防污性能，而不会引起涂层膜缺陷，如开裂。本发明的一个方面提供了一种防污涂层组合物的共聚物，包括具有化学式（1）所表示的基团的侧链上的共聚物（A），以及至少一个化学式（2）所表示的基团和一个化学式（3）所表示的基团中的一个基团。
• MARINE ANTIFOULING AGENT
  申请人：IHARA CHEMICAL INDUSTRY Co., Ltd.

  公开号：EP0706758A1

  公开（公告）日：1996-04-17

  A marine antifouling agent containing at least either a compound represented by general formula (1) or a salt thereof as the active ingredient, wherein R¹ represents a lower alkyl group or a phenyl group which may be substituted by a halogen atom and/or a lower alkyl group; X¹ represents a halogen atom; n represents an integer of 1 to 5, provided when n is 2 or more, X's may be the same or different from one another; Y¹ represents a hydrogen atom or a group -Z-Y²; Z represents a carbonyl or sulfonyl group; and Y² represents an optionally substituted aryl group or a lower alkyl group. This agent is highly safe because of the use of the active ingredient comprising a compound other than organotin compounds, can prevent marine fouling organisms from depositing on ships, underwater constructions, fishnets and so forth even in a small dose, and exhibits a stable antifouling effect for long.

  一种海洋防污剂，至少含有通式(1)代表的化合物或其盐作为活性成分，其中 R¹代表可被卤素原子和/或低级烷基取代的低级烷基或苯基；X¹代表卤素原子；n 代表 1 至 5 的整数，当 n 为 2 或 2 以上时，X 可以相同或不同；Y¹ 代表氢原子或基团-Z-Y²；Z 代表羰基或磺酰基；Y² 代表任选取代的芳基或低级烷基。该制剂由于使用了由有机锡化合物以外的化合物组成的有效成分，因此安全性很高，即使剂量很小，也能防止海洋污损生物沉积在船舶、水下建筑、鱼网等上面，并能长期发挥稳定的防污效果。
• TRIPHENYLBORANE-ROSIN AMINE ADDUCT AND USE OF THE SAME
  申请人：Yoshitomi Fine Chemicals, Ltd.

  公开号：EP0877061A1

  公开（公告）日：1998-11-11

  The triphenylborane-rosin amine adduct shows superior prevention of adhesion, and thus, antifouling effects against coelenterates such as obelia and hydrozoas; shellfish such as barnacle, blue mussel and oyster, tubicolous polychaetes such as Hydroides norvegica, Serpula vermicularis, Pomatoleios kraussii and Dexiospira spirillum and other aquatic organisms. The concurrent use of 1,3-dicyanotetrachlorobenzene, 2-(thiocyanomethylthio)benzothiazole, tetraalkylthiuramdisulfide, 2,3-dichloromaleimide, phenol, dialkylpolysulfide, polybutene, paraffin or petrolatum, and the above-mentioned compound results in the above-mentioned effects. Thus, the above-mentioned compound can be used to provide a preventive of fouling by the aquatic adhesion organisms, an antifouling agent for a fishnet and an antifouling coating, which have superior antifouling effects against fouling organisms such as coelenterates, shellfish, tubicolous polychaetes and the like.

  三苯硼烷-松香胺加合物具有出色的防附着能力，因此对肠衣纲动物（如 Obelia 和 hydrozoas）、贝类（如藤壶、蓝贻贝和牡蛎）、管状多毛目动物（如 Hydroides norvegica、Serpula vermicularis、Pomatoleios kraussii 和 Dexiospira spirillum）以及其他水生生物具有防污效果。同时使用 1,3-二氰基四氯苯、2-（硫氰基甲硫基）苯并噻唑、四烷基秋兰姆二硫化物、2,3-二氯马来酰亚胺、苯酚、二烷基聚硫、聚丁烯、石蜡或凡士林和上述化合物可产生上述效果。因此，上述化合物可用于提供一种水生附着生物污垢预防剂、一种鱼网防污剂和一种防污涂层，对诸如腔肠动物、贝类、管状多毛类等污垢生物具有卓越的防污效果。
• RESINS FOR ANTIFOULING AGENTS AGAINST PERIPHYTONS, PROCESS FOR THE PREPARATION OF THE RESINS, AND ANTIFOULING AGENTS AGAINST PERIPHYTONS CONTAINING THE SAME
  申请人：IHARA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0983997A1

  公开（公告）日：2000-03-08

  The present invention provides: a compound used for production of a resin used in an anti-fouling agent for aquatic fouling organisms, said compound being represented by the following general formula (1): a resin used in an anti-fouling agent for aquatic fouling organisms, which is obtained by polymerizing at least one kind of compound mentioned above and at least one kind of unsaturated monomer selected from other unsaturated monomers having radical-polymerizable double bond, a process for producing a resin used in an anti-fouling agent for aquatic fouling organisms, which is characterized by polymerizing at least one kind of compound mentioned above and at least one kind of unsaturated monomer selected from other unsaturated monomers having radical-polymerizable double bond, and an anti-fouling agent for aquatic fouling organisms, which is characterized by containing a resin mentioned above.

  本发明提供了 一种用于生产水生污损生物防污剂中所用树脂的化合物，所述化合物由以下通式(1)表示： 一种用于水生污损生物防污剂的树脂，它由至少一种上述化合物和至少一种选 自其他具有可自由基聚合双键的不饱和单体的不饱和单体聚合而成、 一种用于水生污损生物防污剂的树脂的生产工艺，其特征在于将至少一种上述化合物和至少一种选自其他具有可自由基聚合双键的不饱和单体的不饱和单体聚合，以及 一种水生污损生物防污剂，其特征在于含有上述树脂。