methyl (E)-2-[(o-tolyl)-(p-tolylsulfonylamino)methyl]-3-(p-tolylsulfonylamino)prop-2-enoate | 1010721-76-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl (E)-2-[(o-tolyl)-(p-tolylsulfonylamino)methyl]-3-(p-tolylsulfonylamino)prop-2-enoate
• 英文别名: methyl (E)-2-[(2-methylphenyl)-[(4-methylphenyl)sulfonylamino]methyl]-3-[(4-methylphenyl)sulfonylamino]prop-2-enoate
• CAS: 1010721-76-2
• 化学式: C₂₆H₂₈N₂O₆S₂
• 分子量: 528.65
• InChiKey: CPVAYDZQTUSPJH-JJIBRWJFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  135
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  三甲基硅烷丙炔甲酯 、 对甲苯磺酰胺 、 N-(2-methylphenyl)methylidene-4-methylbenzenesulfonamide 在 三乙烯二胺 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 以39%的产率得到methyl (E)-2-[(o-tolyl)-(p-tolylsulfonylamino)methyl]-3-(p-tolylsulfonylamino)prop-2-enoate
  参考文献：
  名称：

  Three-Component Coupling Reaction and Cyclization of N-Tosylimines and TMS-Substituted Propiolate Mediated by DABCO

  摘要：

  [GRAPHICS]A new three-component coupling reaction of methyl 3-trimethylsilylpropiolate, N-tosylimine, and tosylamide mediated by DABCO was developed. This reaction was based on the consecutive alpha- and beta-activation method of propiolate involving intramolecular silyl migration previously developed by our group. On the basis of these results, a new cyclization reaction was designed to find a chrome ne-formin g reaction utilizing salicyl N-tosylimine as a bifunctional substrate.

  DOI：

  10.1021/jo702649q

文献信息

• Three-Component Coupling Reaction and Cyclization of <i>N</i>-Tosylimines and TMS-Substituted Propiolate Mediated by DABCO
  作者：Yuji Matsuya、Kousuke Hayashi、Akiho Wada、Hideo Nemoto

  DOI：10.1021/jo702649q

  日期：2008.3.1

  [GRAPHICS]A new three-component coupling reaction of methyl 3-trimethylsilylpropiolate, N-tosylimine, and tosylamide mediated by DABCO was developed. This reaction was based on the consecutive alpha- and beta-activation method of propiolate involving intramolecular silyl migration previously developed by our group. On the basis of these results, a new cyclization reaction was designed to find a chrome ne-formin g reaction utilizing salicyl N-tosylimine as a bifunctional substrate.