N-(2-Hydroxymethyl-isopropyl)-pyrrolidinon | 61484-27-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-(2-Hydroxymethyl-isopropyl)-pyrrolidinon
• 英文别名: 1-(2-hydroxy-1,1-dimethyl-ethyl)-pyrrolidin-2-one；1-(1-Hydroxy-2-methylpropan-2-yl)pyrrolidin-2-one
• CAS: 61484-27-3
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: HDGICOXFRUJDBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-Hydroxymethyl-isopropyl)-pyrrolidinon 在 氯化亚砜 作用下， 以 苯 为溶剂， 反应 10.0h， 以68%的产率得到N-(1,1-Dimethyl-2-chloroethyl)-2-pyrrolidone
  参考文献：
  名称：

  Synthesis and radioprotective properties of some 2-pyrrolidone derivatives

  摘要：

  DOI：

  10.1007/bf00763382
• 作为产物：
  描述：

  γ-丁内酯 、 2-氨基-2-甲基-1-丙醇 生成 N-(2-Hydroxymethyl-isopropyl)-pyrrolidinon
  参考文献：
  名称：

  N-Hydroxyalkyl pyrrolidinone esters as detergent compositions and

  摘要：

  羟基烷基吡咯烷酮酯和烯丙基琥珀酸酐是对碳氢化合物润滑剂和燃料有效的清洁剂添加剂。

  公开号：

  US04397750A1

文献信息

• Prophylactic/Therapeutic Agent for Diabetes
  申请人：Cho Nobuo

  公开号：US20090264650A1

  公开（公告）日：2009-10-22

  The present invention relates to a 11β-hydroxysteroid dehydrogenase 1 inhibitor comprising a compound represented by the formula (1): wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof. The 11β-hydroxysteroid dehydrogenase 1 inhibitor of the present invention has a superior activity, and is useful as a pharmaceutical agent such as agents for the prophylaxis or treatment of diabetes, insulin resistance, obesity, abnormal lipid metabolism, hypertension and the like, and the like.

  本发明涉及一种11β-羟基类固醇脱氢酶1抑制剂，其包括由式（1）表示的化合物，其中每个符号如描述中所定义的，或其盐或前药。本发明的11β-羟基类固醇脱氢酶1抑制剂具有优异的活性，可用作药物剂，如用于预防或治疗糖尿病、胰岛素抵抗、肥胖症、异常脂质代谢、高血压等的药剂。
• PROPHYLACTIC/THERAPEUTIC AGENT FOR DIABETES
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1864971A1

  公开（公告）日：2007-12-12

  The present invention relates to a 11β-hydroxysteroid dehydrogenase 1 inhibitor comprising a compound represented by the formula (1): wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof. The 11β-hydroxysteroid dehydrogenase 1 inhibitor of the present invention has a superior activity, and is useful as a pharmaceutical agent such as agents for the prophylaxis or treatment of diabetes, insulin resistance, obesity, abnormal lipid metabolism, hypertension and the like, and the like.

  本发明涉及一种 11β-羟基类固醇脱氢酶 1 抑制剂，由式（1）代表的化合物组成： 其中各符号如说明中所定义，或其盐，或其原药。本发明的11β-羟类固醇脱氢酶1抑制剂具有优异的活性，可作为药物制剂，如用于预防或治疗糖尿病、胰岛素抵抗、肥胖、脂代谢异常、高血压等疾病的药物。
• LISINA, N. I.;CHERNOV, G. A.;BIZUNOV, YU. M.;EMELYANOV, V. I.;KNUNYANTS, +, XIM.-FARMATS. ZH., 22,(1988) N 6, S. 705-710
  作者：LISINA, N. I.、CHERNOV, G. A.、BIZUNOV, YU. M.、EMELYANOV, V. I.、KNUNYANTS, +

  DOI：——

  日期：——
• Aqueous Ink Jet Composition, Ink Set, Ink Jet Recording Apparatus, And Method For Manufacturing Recorded Matter
  申请人：Seiko Epson Corporation

  公开号：US20210301165A1

  公开（公告）日：2021-09-30

  An aqueous ink jet composition includes a dye component composed of at least one of sublimation dyes and disperse dyes, polyester, 1-(hydroxyalkyl)-2-pyrrolidone, and water, wherein the content (mass %) of the polyester is 4.0 times or more and 300.0 times or less the content (mass %) of the dye component.
• Aqueous Ink Jet Compostion And Method For Manufacturing Recorded Matter
  申请人：Seiko Epson Corporation

  公开号：US20210332254A1

  公开（公告）日：2021-10-28

  An aqueous ink jet composition includes a pigment, polyester, 1-(hydroxyalkyl)-2-pyrrolidone, an organic amine, and water, wherein the pigment, the polyester, and the 1-(hydroxyalkyl)-2-pyrrolidone have a relationship of expression (1): C≤A≤B, where A is the content (mass %) of the pigment with respect to the total mass, B is the content (mass %) of the polyester with respect to the total mass, and C is the content (mass %) of the 1-(hydroxyalkyl)-2-pyrrolidone with respect to the total mass.