indoline lithium salt | 59092-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: indoline lithium salt
• 英文别名: lithium indolide；Lithium;2,3-dihydroindol-1-ide；lithium;2,3-dihydroindol-1-ide
• CAS: 59092-48-7
• 化学式: C₈H₈N*Li
• 分子量: 125.099
• InChiKey: OYSDOELCYLCDGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.75
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  indoline lithium salt 在 三氯硅烷 、 三乙胺 作用下， 生成 1-(2-Diphenylphosphanyl-6-methoxy-phenyl)-2,3-dihydro-1H-indole
  参考文献：
  名称：

  A C(aryl)N(amine) bond atropisomeric aminophosphine: preparation and use as a ligand in a catalytic asymmetric allylic alkylation

  摘要：

  The existence of 3 as a pair of stable atropisomers has been demonstrated analytically through chiral phase LC-CD investigations. Resolution of 3d was achieved by preparative chiral HPLC. Finally, the ability of the first C(aryl)-N(amine) axially chiral phosphine ligand 3d is demonstrated in a catalytic asymmetric reaction. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00545-7

文献信息

• Reaction of magnesium cyclopropylidene with N-lithio arylamines: a method for generation of α-amino-substituted cyclopropylmagnesiums and a study for their reactivity with electrophiles
  作者：Tsuyoshi Satoh、Mariko Miura、Ken Sakai、Yoshimi Yokoyama

  DOI：10.1016/j.tet.2006.01.080

  日期：2006.4

  Magnesium cyclopropylidene was generated from 1-chlorocyclopropyl phenyl sulfoxide with i-PrMgCl in THF at -78 degrees C in high yield by a sulfoxide-magnesium exchange reaction. The generated magnesium cyclopropylidene was found to be reactive with N-lithio arylamines to give alpha-ammo-substituted cyclopropylmagnesiums. The reaction of the a-amino-substituted cyclopropylmagnesiums with several electrophiles was examined and a new method for a synthesis of cyclopropane amino acid derivatives was realized. (c) 2006 Elsevier Ltd. All rights reserved.
• A C(aryl)N(amine) bond atropisomeric aminophosphine: preparation and use as a ligand in a catalytic asymmetric allylic alkylation
  作者：Takashi Mino、Youichi Tanaka、Toshihiro Yabusaki、Daisuke Okumura、Masami Sakamoto、Tsutomu Fujita

  DOI：10.1016/s0957-4166(03)00545-7

  日期：2003.9

  The existence of 3 as a pair of stable atropisomers has been demonstrated analytically through chiral phase LC-CD investigations. Resolution of 3d was achieved by preparative chiral HPLC. Finally, the ability of the first C(aryl)-N(amine) axially chiral phosphine ligand 3d is demonstrated in a catalytic asymmetric reaction. (C) 2003 Elsevier Ltd. All rights reserved.