23-azido-1-fluoro-3,6,9,12,15,18,21-heptaoxatricosane | 1223564-33-7

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 23-azido-1-fluoro-3,6,9,12,15,18,21-heptaoxatricosane
• 英文别名: 1-azido-2-[2-[2-[2-[2-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethane
• CAS: 1223564-33-7
• 化学式: C₁₆H₃₂FN₃O₇
• 分子量: 397.444
• InChiKey: GZUXKSWSYVPVJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  27
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  23-azido-1-fluoro-3,6,9,12,15,18,21-heptaoxatricosane 在 四丁基铵碳酸氢酯 、 氢氟酸 作用下， 以 乙腈 为溶剂， 生成 1-azido-2-[2-[2-[2-[2-[2-[2-(2-(18F)fluoranylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethane
  参考文献：
  名称：

  A Modular Platform for the Rapid Site-Specific Radiolabeling of Proteins with ¹⁸F Exemplified by Quantitative Positron Emission Tomography of Human Epidermal Growth Factor Receptor 2

  摘要：

  Receptor-specific proteins produced by genetic engineering are attractive as PET imaging agents, but labeling with conventional F-18-based prosthetic groups is problematic due to long synthesis times, poor radiochemical yields, and low specific activities. Therefore, we developed a modular platform for the rapid preparation of water-soluble prosthetic groups capable of efficiently introducing F-18 into proteins. The utility of this platform is demonstrated by the thiol-specific prosthetic group, [F-18]FPEGMA, which was used to produce site-specifically F-18-labeled protein (F-18-trastuzumab-ThioFab) in 82 min with a total radiochemical yield of 13 +/- 3% and a specific activity of 2.2 +/- 0.2 Ci/mu mol. F-18-trastuzumab-ThioFab retained the biological activity of native protein and was successfully validated in vivo with microPET imaging of Her2 expression in a xenograft tumor-bearing murine model modulated by. the Hsp90 inhibitor, 17-(allylamino)-17-demethoxygeldanamycin.

  DOI：

  10.1021/jm900420c
• 作为产物：
  描述：

  O-(2-叠氮乙基)七聚乙二醇 在 trans-4,4'-diaminostilbene-2,2'-disulfonic acid 作用下， 以 水 、 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 为溶剂， 以122 mg (24%)的产率得到23-azido-1-fluoro-3,6,9,12,15,18,21-heptaoxatricosane
  参考文献：
  名称：

  METHODS AND COMPOSITIONS FOR PROTEIN LABELLING

  摘要：

  提供了一个模块化平台，用于快速准备各种水溶性假体基团，能够有效地将 18 F引入蛋白质中，使用 18 F标记试剂。

  公开号：

  US20100221176A1

文献信息

• Methods and compositions for protein labelling
  申请人：Genentech, Inc.

  公开号：US08865122B2

  公开（公告）日：2014-10-21

  A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.

  提供了一个模块化平台，用于快速制备各种水溶性假体基团，能够利用18F标记试剂高效地将18F引入蛋白质中。
• US8435488B2
  申请人：——

  公开号：US8435488B2

  公开（公告）日：2013-05-07
• US8865122B2
  申请人：——

  公开号：US8865122B2

  公开（公告）日：2014-10-21
• [EN] METHODS AND COMPOSITIONS FOR PROTEIN LABELLING<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LE MARQUAGE DES PROTÉINES
  申请人：GENENTECH INC

  公开号：WO2010099273A1

  公开（公告）日：2010-09-02

  A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.