Methyl S-(2-Hydroxyethyl)thioglycolate | 61146-95-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl S-(2-Hydroxyethyl)thioglycolate
• 英文别名: Carbmethoxymethylthioethanol；Methyl [(2-hydroxyethyl)sulfanyl]acetate；methyl 2-(2-hydroxyethylsulfanyl)acetate
• CAS: 61146-95-0
• 化学式: C₅H₁₀O₃S
• mdl: MFCD12178663
• 分子量: 150.199
• InChiKey: WAQUCCRUGCZVGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl S-(2-Hydroxyethyl)thioglycolate 生成 1,4-恶噻烷-2-酮
  参考文献：
  名称：

  Hellberg Jonas, Moge Mikael, Bauer Dagmar, von Schuetz Jost-Ulrich, Synth. Metals, 70 (1995) N 1-3, S 1135-1136

  摘要：

  DOI：
• 作为产物：
  描述：

  重氮甲烷 、 2-羟基乙基硫代乙酸酯 生成 Methyl S-(2-Hydroxyethyl)thioglycolate
  参考文献：
  名称：

  Kawashima, Hideki, Bioscience, Biotechnology and Biochemistry, 1995, vol. 59, # 5, p. 934 - 935

  摘要：

  DOI：

文献信息

• Synthesis and pharmacological properties of N-(3-{3-(1-piperidinylmethyl)phenoxy}propyl)-2-(2-hydroxyethylthio)acetamide and related compounds as antiulcer agents. I.
  作者：Ikuo UEDA、Katsuyuki ISHII、Katsuo SHINOZAKI、Masao SEIKI、Heihachiro ARAI、Minoru HATANAKA

  DOI：10.1248/cpb.38.3035

  日期：——

  N-Phenoxypropylacetamide derivatives were prepared and tested for antiulcer activity. These compounds exhibited both gastric acid antisecretory and cytoprotective properties. Structure-activity studies led to the identification of N-[3-(3-(1-piperidinylmethyl)phenoxy)propyl]-2-(2-hydroxyethylt hio)acetamide (8), which was selected for further development and clinical evaluation.

  制备了N-苯氧基丙基乙酰胺衍生物，并测试了其抗溃疡活性。这些化合物显示出胃酸的抗分泌和细胞保护性能。结构活性研究导致鉴定出N- [3-（3-（1-（哌啶基甲基甲基）苯氧基）丙基] -2-（2-羟乙基硫代）乙酰胺（8），该化合物被选作进一步开发和临床评估。
• Synthesis of 1,3-oxathiolane derivatives as novel precursors of 2′,3′-dideoxy-3′-oxa-4′-thioribonucleosides
  作者：Junzo Nokami、Kazuyo Ryokume、Junya Inada

  DOI：10.1016/0040-4039(95)01213-2

  日期：1995.8

  β′-hydroxy sulfides and were converted into 4-acetoxy-1,3-oxathiolanes, precursors of 2′,3′-dideoxy-3′-oxa-4′-thioribonucleosides, by the electrolytic acetoxylation of the 1,3-oxathiolane or by Pummerer rearrangement via sulfoxide.

  通过β'-羟基硫化物的电化学化学选择性α-乙酰氧基化反应制备1,3-氧杂硫杂环戊烷，然后将其转化为4-乙酰氧基-1,3-氧杂硫杂环戊烷，即2'，3'-二甲氧基-3'-oxa-4'的前体。 -硫代核糖核苷，通过1,3-氧杂硫杂环戊烷的电解乙酰氧基化或通过亚砜进行的Pummerer重排。
• Inhibition of mevalonate 5-pyrophosphate decarboxylase by a proline-containing transition state analog
  作者：Isidoros Vlattas、James Dellureficio、Edmund Ku、Regine Bohacek、Xiaolu Zhang

  DOI：10.1016/0960-894x(96)00374-5

  日期：1996.9

  Mevalonate 5-pyrophosphate decarboxylase is involved in the conversion of MevPP to IPP in the biosynthesis of steroids and terpenoids from mevalonate. Based on a hypothetical model of the transition state of this enzymatic transformation we have synthesized novel hydroxyacetyl proline analogs that are potent inhibitors of the enzyme. Copyright (C) 1996 Elsevier Science Ltd
• CEDA, IKUO;ISHII, KATSUYUKI;SHINOZAKI, KATSUO;SEIKI, MASAO;ARAI, HEIHACHI+, CHEM. AND PHARM. BULL., 38,(1990) N1, C. 3035-3041
  作者：CEDA, IKUO、ISHII, KATSUYUKI、SHINOZAKI, KATSUO、SEIKI, MASAO、ARAI, HEIHACHI+

  DOI：——

  日期：——
• Hellberg Jonas, Moge Mikael, Bauer Dagmar, von Schuetz Jost-Ulrich, Synth. Metals, 70 (1995) N 1-3, S 1135-1136
  作者：Hellberg Jonas, Moge Mikael, Bauer Dagmar, von Schuetz Jost-Ulrich

  DOI：——

  日期：——