6-(indol-5-oyl)amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole | 186544-32-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-(indol-5-oyl)amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole
• 英文别名: N-[6-(dimethylamino)-6,7,8,9-tetrahydro-5H-carbazol-3-yl]-1H-indole-5-carboxamide
• CAS: 186544-32-1
• 化学式: C₂₃H₂₄N₄O
• 分子量: 372.47
• InChiKey: ABSNQVFIEDDDTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  63.9
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吲哚-5-羧酸 、 6-amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole 在 N,N'-羰基二咪唑 作用下， 以 N-甲基乙酰胺 、 甲醇 为溶剂， 以66.7 mg (69%)的产率得到6-(indol-5-oyl)amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole
  参考文献：
  名称：

  6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and

  摘要：

  这项发明提供了新颖的6-取代-1,2,3,4-四氢-9H-咔唑和7-取代-10H-环庚\x9b7,6-b!吲哚。这些化合物是5-HT.sub.1F激动剂，对治疗偏头痛及相关疾病有用。

  公开号：

  US05708187A1

文献信息

• Use of serotonin 5-HT1F agonists for the prevention of migraine
  申请人：ELI LILLY AND COMPANY

  公开号：EP0832650A3

  公开（公告）日：1998-09-02

  This invention provides methods for the prevention of migraine which comprises administering to a mammal in need thereof a serotonin 5-HT1F agonist.

  这项发明提供了预防偏头痛的方法，包括向需要的哺乳动物施用一种5-HT1F受体激动剂。
• Use of a serotonin 5-HTlf agonist in the manufacture of a medicament for treating or ameliorating the symptoms of common cold or allergic rhinitis
  申请人：ELI LILLY AND COMPANY

  公开号：EP0824917A3

  公开（公告）日：2000-08-30

  This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT1F agonist.

  这项发明提供了治疗或缓解普通感冒或过敏性鼻炎症状的方法，包括向需要的哺乳动物施用一种5-HT1F受体激动剂。
• Methods of treating or ameliorating the symptoms of common cold or
  申请人：Eli Lilly and Company

  公开号：US05962473A1

  公开（公告）日：1999-10-05

  This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT.sub.1F agonist.

  这项发明提供了治疗或改善普通感冒或过敏性鼻炎症状的方法，包括向需要的哺乳动物施用一种5-羟色胺5-HT.sub.1F激动剂。
• Pharmaceutical method using 6-substituted-1, 2, 3,
  申请人：Eli Lilly and Company

  公开号：US05814653A1

  公开（公告）日：1998-09-29

  This invention provides novel 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta\x9b7,6-b!indoles. These compounds are 5-HT.sub.1F agonists which are useful for the treatment of migraine and associated disorders.

  本发明提供了新型的6-取代-1,2,3,4-四氢-9H-咔唑和7-取代-10H-环庚[7,6-b]吲哚。这些化合物是5-HT.sub.1F激动剂，可用于治疗偏头痛和相关疾病。
• Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists
  申请人：Eli Lilly and Company

  公开号：US06380201B1

  公开（公告）日：2002-04-30

  This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT1F agonist.

  本发明提供了一种治疗或缓解普通感冒或过敏性鼻炎症状的方法，包括向需要该治疗的哺乳动物施用一种5-羟色胺5-HT1F激动剂。