methyl (3S)-3-(4-nitrophenyl)-3-trimethylsilyloxypropanoate | 1027204-83-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl (3S)-3-(4-nitrophenyl)-3-trimethylsilyloxypropanoate
• CAS: 1027204-83-6
• 化学式: C₁₃H₁₉NO₅Si
• 分子量: 297.383
• InChiKey: CENBXRBXWSTJLC-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.05
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  81.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl (3S)-3-(4-nitrophenyl)-3-trimethylsilyloxypropanoate 在 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 Methyl (S)-3-Hydroxy-3-(4-nitrophenyl)propanoate
  参考文献：
  名称：

  The Mukaiyama Aldol and Mukaiyama–Michael Reactions Promoted by Commercially Available Molecular Sieves

  摘要：

  The Mukaiyama aldol reaction of silyl ketene acetals with aldehydes has been effected by using commercially available 4 angstrom molecular sieves (4 angstrom MS) as a promoter. Various silyl ketene acetals and silyl enol ethers have been shown to be effective nucleophiles for this reaction. For the first time, it has been found that 4 angstrom MS can promote the Mukaiyama Michael addition reactions of silyl ketene acetals to alpha,beta-enones.

  DOI：

  10.3987/com-09-s(s)133
• 作为产物：
  描述：

  [(1-methoxyvinyl)oxy]trimethylsilane 、 对硝基苯甲醛 在 Rh₂(S-BPTPI)4 作用下， 以 甲苯 为溶剂， 生成 methyl (3S)-3-(4-nitrophenyl)-3-trimethylsilyloxypropanoate
  参考文献：
  名称：

  The Mukaiyama Aldol and Mukaiyama–Michael Reactions Promoted by Commercially Available Molecular Sieves

  摘要：

  The Mukaiyama aldol reaction of silyl ketene acetals with aldehydes has been effected by using commercially available 4 angstrom molecular sieves (4 angstrom MS) as a promoter. Various silyl ketene acetals and silyl enol ethers have been shown to be effective nucleophiles for this reaction. For the first time, it has been found that 4 angstrom MS can promote the Mukaiyama Michael addition reactions of silyl ketene acetals to alpha,beta-enones.

  DOI：

  10.3987/com-09-s(s)133