N-[4-(2,6-dioxopiperidin-1-yl)-2-phenoxyphenyl]methanesulfonamide | 1247004-20-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-(2,6-dioxopiperidin-1-yl)-2-phenoxyphenyl]methanesulfonamide
• CAS: 1247004-20-1
• 化学式: C₁₈H₁₈N₂O₅S
• 分子量: 374.417
• InChiKey: YSARXDLRPZVRFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  戊二酸酐 、 N-(4-氨基-2-苯氧基苯基)甲烷磺酰胺 在 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 0.33h， 以75%的产率得到N-[4-(2,6-dioxopiperidin-1-yl)-2-phenoxyphenyl]methanesulfonamide
  参考文献：
  名称：

  Lewis acid free high speed synthesis of nimesulide-based novel N-substituted cyclic imides

  摘要：

  The first synthesis of nimesulide-based novel cyclic imides has been accomplished via the reaction of an amine prepared from nimesulide with appropriate anhydrides in the presence of sodium acetate. Using this process a variety of N-substituted cyclic imides was prepared in good yields in glacial acetic acid. Some of the compounds synthesized showed anti-inflammatory activities when tested in vivo.

  DOI：

  10.1590/s0103-50532010000600015

文献信息

• Lewis acid free high speed synthesis of nimesulide-based novel N-substituted cyclic imides
  作者：Kavitha Kankanala、Vangala Ranga Reddy、Khagga Mukkanti、Sarbani Pal

  DOI：10.1590/s0103-50532010000600015

  日期：——

  The first synthesis of nimesulide-based novel cyclic imides has been accomplished via the reaction of an amine prepared from nimesulide with appropriate anhydrides in the presence of sodium acetate. Using this process a variety of N-substituted cyclic imides was prepared in good yields in glacial acetic acid. Some of the compounds synthesized showed anti-inflammatory activities when tested in vivo.