申请人:PHARMACYCLICS, INC.
公开号:US20150045367A1
公开(公告)日:2015-02-12
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.
本文描述了一些化合物和含有这些化合物的药物组合物,这些化合物可以抑制组蛋白去乙酰化酶8(HDAC8)的活性。本文还描述了使用这些HDAC8抑制剂的方法,单独或与其他化合物联合使用,用于治疗需要抑制HDAC8活性的疾病或情况。