4-methyl-N-(p-tolyl)pyridin-2-amine | 1237535-39-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-(p-tolyl)pyridin-2-amine
• 英文别名: N-(4-methylpyridin-2-yl)-4-methylaniline；N-(4-Methyl-2-pyridyl)-p-toluidine；4-methyl-N-(4-methylphenyl)pyridin-2-amine
• CAS: 1237535-39-5
• 化学式: C₁₃H₁₄N₂
• 分子量: 198.268
• InChiKey: DHJXECYEZFEJBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methyl-N-(p-tolyl)pyridin-2-amine 在 甲酸 、 二乙酰二(三苯基膦)钯 、 lithium perchlorate 作用下， 以 乙腈 为溶剂， 反应 13.0h， 以95%的产率得到3,8-Dimethylpyrido[1,2-a]benzimidazole
  参考文献：
  名称：

  钯催化的电化学氧化CH-H胺用于合成并析出氢的吡啶并[1,2- a ]苯并咪唑

  摘要：

  过渡金属催化的C–H / N–H氧化偶联反应是构建C–N键的重要方法。但是，通常需要化学计量的氧化剂。在这里，我们报道了没有外部氧化剂或添加剂的钯催化的电氧化分子内CH / NH环化反应。通过简单，绿色和温和的途径构建了各种吡啶并[1,2- a ]苯并咪唑。实验结果表明，Pd（0）可以在阳极上被氧化再利用。

  DOI：

  10.1021/acscatal.0c00103
• 作为产物：
  描述：

  2-溴-4-甲基吡啶 、 乙烷,三氯氟- 在 tris-(dibenzylideneacetone)dipalladium(0) 、 potassium tert-butylate 、 双(2-二苯基磷苯基)醚 作用下， 以 甲苯 为溶剂， 以92%的产率得到4-methyl-N-(p-tolyl)pyridin-2-amine
  参考文献：
  名称：

  Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via C–H Activation/C–C Coupling and Synthetic Applications

  摘要：

  The direct ortho arylation of 4-methyl-N-phenylpyridin-2-amines via palladium(II)-catalyzed C-H activation is described. Treatment of 4-methyl-N-phenylpyridin-2-amine with potassium aryltrifluoroborate using 10 mol % of palladium(II) acetate as the catalyst, 2 equiv of copper(II) acetate as the oxidant, and 1 equiv of p-benzoquinone in tert-butyl alcohol gave ortho-arylated products in modest to excellent yields. This reaction shows good functional group compatibility. A series of H-1 NMR titration experiments and controlled experiments elucidating the reaction mechanism were carried out. The key intermediate, 4-methyl-N-phenylpyridin-2-amine palladacycle, was isolated and characterized by X-ray crystallography. The advanced transformations of ortho-phenylated 4-methyl-N-phenylpyridin-2-amine to N-(4-methylpyridin-2-yl)-9H-carbazole, biphenyl-2-amine, and 3-methyl-6-phenylpyrido[1,2-a]benzimidazole were successfully demonstrated as potential synthetic applications.

  DOI：

  10.1021/om401195w

文献信息

• CROSSLINKING AGENT COMPOSITION, LIQUID CRYSTAL ALIGNMENT AGENT COMPOSITION COMPRISING SAME, METHOD FOR PREPARING LIQUID CRYSTAL ALIGNMENT FILM BY USING SAME, AND LIQUID CRYSTAL ALIGNMENT FILM AND LIQUID CRYSTAL DISPLAY DEVICE WHICH USE SAME
  申请人：LG CHEM, LTD.

  公开号：EP3747890A1

  公开（公告）日：2020-12-09

  The present invention relates to a cross-linking agent compound of which end functional group is substituted with a protection group of a specific structure, a liquid crystal alignment composition comprising the cross-linking agent compound and polymer containing repeat units of polyimide or a precursor thereof, a method of preparing liquid crystal alignment film, a liquid crystal alignment film, and a liquid crystal display using the same.

  本发明涉及一种末端官能团被特定结构的保护基团取代的交联剂化合物、一种由该交联剂化合物和含有聚酰亚胺重复单元的聚合物或其前体组成的液晶配向组合物、一种制备液晶配向膜的方法、一种液晶配向膜和一种使用该组合物的液晶显示器。
• Liquid crystal aligning agent composition, method for preparing liquid crystal alignment film using same, and liquid crystal alignment film using same
  申请人：LG CHEM, LTD.

  公开号：US10982147B2

  公开（公告）日：2021-04-20

  The present invention relates to a liquid crystal aligning agent composition for forming a liquid crystal alignment film exhibiting excellent alignment and electrical characteristics and simultaneously having excellent film strength, a method for preparing a liquid crystal alignment film using the same, and a liquid crystal alignment film and a liquid crystal display device using the same.

  本发明涉及一种用于形成液晶配向膜的液晶配向剂组合物，该液晶配向剂组合物具有优异的配向和电气特性，并同时具有优异的膜强度；一种使用该液晶配向剂组合物制备液晶配向膜的方法；以及一种使用该液晶配向剂组合物的液晶配向膜和液晶显示设备。
• Liquid crystal alignment agent composition, method for preparing liquid crystal alignment film using same, and liquid crystal alignment film and liquid crystal display using same
  申请人：LG CHEM, LTD.

  公开号：US11149204B2

  公开（公告）日：2021-10-19

  Provided is a liquid crystal alignment agent composition comprising a terminal modifier compound containing an amino group together with a polyimide containing an acid anhydride group at its terminus or a precursor polymer thereof, a method for preparing a liquid crystal alignment film using the same, and a liquid crystal alignment film and a liquid crystal display using the same.

  本发明提供了一种液晶配向剂组合物，该组合物由含有氨基的末端改性剂化合物与末端含有酸酐基团的聚酰亚胺或其前体聚合物组成，还提供了一种使用该组合物制备液晶配向膜的方法，以及一种使用该组合物的液晶配向膜和液晶显示器。
• Liquid crystal aligning agent composition, method for preparing liquid crystal alignment film using same, and liquid crystal alignment film and liquid crystal display using same
  申请人：LG CHEM, LTD.

  公开号：US11307462B2

  公开（公告）日：2022-04-19

  Provided is a liquid crystal aligning agent composition comprising a hindered amine-based light stabilizer and a polyamic acid polymer derived from a diamine, a method for preparing a liquid crystal alignment film using the same, and a liquid crystal alignment film and a liquid crystal display using the same.

  本发明提供了一种液晶配向剂组合物，该组合物由受阻胺基光稳定剂和二胺衍生的聚酰胺酸聚合物组成，还提供了使用该组合物制备液晶配向膜的方法，以及使用该组合物制备液晶配向膜和液晶显示器的方法。
• LIQUID CRYSTAL ALIGNING AGENT COMPOSITION, METHOD FOR PREPARING LIQUID CRYSTAL ALIGNMENT FILM USING SAME, AND LIQUID CRYSTAL ALIGNMENT FILM USING SAME
  申请人：LG CHEM, LTD.

  公开号：US20190256778A1

  公开（公告）日：2019-08-22

  The present invention relates to a liquid crystal aligning agent composition for forming a liquid crystal alignment film exhibiting excellent alignment and electrical characteristics and simultaneously having excellent film strength, a method for preparing a liquid crystal alignment film using the same, and a liquid crystal alignment film and a liquid crystal display device using the same.