1-p-Bromphenyl-4-phenyl-3-pyrrolin-2-on | 61923-82-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 1-p-Bromphenyl-4-phenyl-3-pyrrolin-2-on
• 英文别名: 1-(4-bromophenyl)-4-phenyl-1,5-dihydro-pyrrole-2-one；1-(4-bromo-phenyl)-4-phenyl-1,5-dihydro-pyrrol-2-one；2H-Pyrrol-2-one, 1-(4-bromophenyl)-1,5-dihydro-4-phenyl-；1-(4-bromophenyl)-3-phenyl-2H-pyrrol-5-one
• CAS: 61923-82-8
• 化学式: C₁₆H₁₂BrNO
• 分子量: 314.181
• InChiKey: BLBZTRXJBUBVST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-p-Bromphenyl-4-phenyl-3-pyrrolin-2-on 、 N,N-二甲基甲酰胺 在 三氯氧磷 作用下， 以 氯仿 为溶剂， 以70%的产率得到1-(4-bromophenyl)-5-chloro-3-phenylpyrrole-2,4-dicarbaldehyde
  参考文献：
  名称：

  A novel access to bisformylated pyrroles via decarboxylation of N-aryl-γ-lactam-carboxylic acids under Vilsmeier reaction conditions

  摘要：

  A simple methodology for the conversion of substituted N-aryl-gamma-lactam 2/3-carboxylic acids to substituted N-aryl-diformylated pyrroles has been developed. Several gamma-lactam 2/3-carboxylic acids were subjected to Vilsmeier reagent and substituted diformylated pyrroles are isolated in one-step process. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.11.005
• 作为产物：
  描述：

  以 乙腈 为溶剂， 生成 1-p-Bromphenyl-4-phenyl-3-pyrrolin-2-on
  参考文献：
  名称：

  A novel access to bisformylated pyrroles via decarboxylation of N-aryl-γ-lactam-carboxylic acids under Vilsmeier reaction conditions

  摘要：

  A simple methodology for the conversion of substituted N-aryl-gamma-lactam 2/3-carboxylic acids to substituted N-aryl-diformylated pyrroles has been developed. Several gamma-lactam 2/3-carboxylic acids were subjected to Vilsmeier reagent and substituted diformylated pyrroles are isolated in one-step process. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.11.005

文献信息

• A novel access to bisformylated pyrroles via decarboxylation of N-aryl-γ-lactam-carboxylic acids under Vilsmeier reaction conditions
  作者：Gopa Barman、Jayanta K. Ray

  DOI：10.1016/j.tetlet.2009.11.005

  日期：2010.1

  A simple methodology for the conversion of substituted N-aryl-gamma-lactam 2/3-carboxylic acids to substituted N-aryl-diformylated pyrroles has been developed. Several gamma-lactam 2/3-carboxylic acids were subjected to Vilsmeier reagent and substituted diformylated pyrroles are isolated in one-step process. (C) 2009 Elsevier Ltd. All rights reserved.