methyl chloropyruvate | 922-19-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: methyl chloropyruvate
• 英文别名: Chlor-brenztraubensaeure-methylester；Methyl 3-chloro-2-oxopropanoate
• CAS: 922-19-0
• 化学式: C₄H₅ClO₃
• 分子量: 136.535
• InChiKey: NBBBHSSRYQINTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl chloropyruvate 在 盐酸 作用下， 生成 3-氯-2-氧代丙酸
  参考文献：
  名称：

  Ratusky; Sorm, Collection of Czechoslovak Chemical Communications, 1958, vol. 23, p. 467,472

  摘要：

  DOI：
• 作为产物：
  描述：

  丙酮酸甲酯 在 磺酰氯 作用下， 以 四氯化碳 为溶剂， 生成 methyl chloropyruvate
  参考文献：
  名称：

  The Reaction of Oxalyl Chloride with Amides. I. The Preparation of Furanone Amines

  摘要：

  DOI：

  10.1021/jo01059a054

文献信息

• Thienopyridones as AMPK activators for the treatment of diabetes and obesity
  申请人：Iyengar R. Rajesh

  公开号：US20050038068A1

  公开（公告）日：2005-02-17

  The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.

  本发明涉及激活AMP-激活蛋白激酶（AMPK）的化合物，包括制备这些化合物、含有这些化合物的组合物以及利用这些化合物在预防或治疗糖尿病、代谢综合征和肥胖等疾病中的用途。
• Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties
  作者：Claire Sablayrolles、Jean Claude Milhavet、Eliane Rechenq、Jean Pierre Chapat、Gerard H. Cros、Maurice Boucard、Jean J. Serrano、John H. McNeill

  DOI：10.1021/jm00368a018

  日期：1984.2

  A series of imidazo[1,2-alpha]pyrazine derivatives was synthesized by condensation of alpha-halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo-[1,2-alpha]pyrazine showed positive chronotropic and inotropic

  通过α-卤代羰基化合物和氨基吡嗪的缩合合成了一系列咪唑并[1,2-α-吡嗪]衍生物。各种化合物是由竞争反应或试剂异构化产生的，并表现出体外子宫松弛和体内抗支气管痉挛活性。在分离的心房上，5-溴咪唑并[1,2-α]吡嗪表现出正变时性和变力性。后者与循环AMP组织浓度的增加有关。5-溴咪唑并[1,2-α]吡嗪对异丙肾上腺素的正性肌力作用的增强和普萘洛尔对5-溴咪唑并[1,2-α]吡嗪正性肌力的缺乏的缺乏提示磷酸二酯酶抑制性质。
• Total Synthesis of the <i>Aspidosperma</i> Alkaloid (±)-Subincanadine F via a Titanium-Mediated Intramolecular Nucleophilic Acyl Substitution Strategy
  作者：Xiayun Cheng、Chelsea M. Duhaime、Stephen P. Waters

  DOI：10.1021/jo1015823

  日期：2010.10.15

  The total synthesis of the bridge-fused Aspidosperma indole alkaloid (±)-subincanadine F has been accomplished in seven steps. The synthetic utility of a titanium-mediated intramolecular nucleophilic acyl substitution (INAS) reaction for the construction of the bridge-fused ring system was demonstrated.

  桥融合的Aspidosperma吲哚生物碱 (±)-subincanadine F的全合成分七个步骤完成。证明了钛介导的分子内亲核酰基取代 (INAS) 反应在构建桥连环系统中的合成效用。
• [EN] PYRAZOLYL PYRROLINONES AND THEIR USE AS HERBICIDES<br/>[FR] PYRAZOLYLE PYRROLINONES ET LEUR UTILISATION EN TANT QU'HERBICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2015018434A1

  公开（公告）日：2015-02-12

  The invention relates to pyrrolone compounds of the formula (I) wherein X, Ra, Rb, Rc, R1, R2 and R3 are as defined in the specification. Furthermore, the present invention relates to processes and intermediates for making compounds of formula (I), to herbicidal compositions comprising these compounds and to methods of using these compounds to control plant growth.

  该发明涉及式(I)的吡咯酮化合物，其中X、Ra、Rb、Rc、R1、R2和R3如规范中定义。此外，本发明涉及制备式(I)化合物的过程和中间体，包括这些化合物的除草剂组合物，以及使用这些化合物控制植物生长的方法。
• A one-pot procedure for ring enlargement of α-chloromethyl<i>N</i>-containing heterocycles
  作者：Lianyou Zheng、Jinbao Xiang、Xu Bai

  DOI：10.1002/jhet.5570430211

  日期：2006.3

  A simple one-pot procedure for ring enlargement of α-chloromethyl N-containing heterocycles has been developed. By reaction of chloromethyl tetrahydroisoquinoline and its thieno analog with benzyl or allyl bromide under basic conditions, ring expansion and N-substitution were achieved simultaneously. The key to the transformation was proposed to involve the formation of aziridinium salt and subsequent

  已经开发出一种简单的一锅法，用于扩环含α-氯甲基N的杂环。在碱性条件下，通过使氯甲基四氢异喹啉及其噻吩类似物与苄基或烯丙基溴反应，可以同时实现扩环和N-取代。提出了转化的关键，包括形成氮丙啶鎓盐以及随后氮和叔碳原子之间的键断裂。