N,N'-Diethylethylendiamin-N,N'-diacetat | 7532-84-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-Diethylethylendiamin-N,N'-diacetat
• 英文别名: N,N'-Ethylenenebis(N-ethylglycine)；2-[2-[carboxymethyl(ethyl)amino]ethyl-ethylamino]acetic acid
• CAS: 7532-84-5
• 化学式: C₁₀H₂₀N₂O₄
• 分子量: 232.28
• InChiKey: HNSBDQCYENWVJU-UHFFFAOYSA-N

物化性质

• 熔点：
  205-208 °C (decomp)
• 沸点：
  385.2±32.0 °C(Predicted)
• 密度：
  1.176±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  81.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N,N'-Diethylethylendiamin-N,N'-diacetat 在 亚磷酸 、 三氯化磷 、 水 作用下， 以 氯苯 为溶剂， 反应 6.0h， 以35%的产率得到
  参考文献：
  名称：

  Synthesis and cytotoxicity of N,N′-dibisphosphonate ethylenediamine derivatives and platinum(II) complexes with high binding property to hydroxyapatite

  摘要：

  A series of N,N '-dibisphosphonate ethylenediamine derivatives (L1-L6) and their corresponding dichloroplatinum(II) complexes (1-6) have been prepared and characterized by elemental analysis, H-1 NMR, C-13 NMR, P-31 NMR, and HRMS spectra. The in vitro antitumor of compounds L1-L6 and 1-6 was tested by WST-8 assay with Cell Counting Kit-8, indicating that platinum-based complexes 1-6 showed higher cytotoxic efficacy than platinum-free compounds L1-L6 against SKOV3 and MG-63, especially complex 2 (R = CH3, n = 2) with comparable cytotoxicity to cisplatin after 72 h incubation. And complexes 1-6 were highly selective in cytotoxicity against MG-63 tumor cells than hFOB 1.19 normal cells. The in vitro hydroxyapatite binding test revealed that complexes 1 and 2 showed higher affinity (K ' = 4.2 and 3.5, respectively) for bone hydroxyapatite than cisplatin (K ' < 0.1) and zoledronate (K ' = 2.8). On basis of flow cytometry results, complex 2 induced cell death by apoptosis effect similar to cisplatin, different from zoledronate. Representative complex 2 has been proved to be a promising bone-targeting antitumor agent for subsequent in vivo study. (C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2016.12.006
• 作为产物：
  描述：

  N,N-二乙基乙二胺 、 氯乙酸 在 aluminum trihydroxide 作用下， 生成 N,N'-Diethylethylendiamin-N,N'-diacetat
  参考文献：
  名称：

  Synthesis and cytotoxicity of N,N′-dibisphosphonate ethylenediamine derivatives and platinum(II) complexes with high binding property to hydroxyapatite

  摘要：

  A series of N,N '-dibisphosphonate ethylenediamine derivatives (L1-L6) and their corresponding dichloroplatinum(II) complexes (1-6) have been prepared and characterized by elemental analysis, H-1 NMR, C-13 NMR, P-31 NMR, and HRMS spectra. The in vitro antitumor of compounds L1-L6 and 1-6 was tested by WST-8 assay with Cell Counting Kit-8, indicating that platinum-based complexes 1-6 showed higher cytotoxic efficacy than platinum-free compounds L1-L6 against SKOV3 and MG-63, especially complex 2 (R = CH3, n = 2) with comparable cytotoxicity to cisplatin after 72 h incubation. And complexes 1-6 were highly selective in cytotoxicity against MG-63 tumor cells than hFOB 1.19 normal cells. The in vitro hydroxyapatite binding test revealed that complexes 1 and 2 showed higher affinity (K ' = 4.2 and 3.5, respectively) for bone hydroxyapatite than cisplatin (K ' < 0.1) and zoledronate (K ' = 2.8). On basis of flow cytometry results, complex 2 induced cell death by apoptosis effect similar to cisplatin, different from zoledronate. Representative complex 2 has been proved to be a promising bone-targeting antitumor agent for subsequent in vivo study. (C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2016.12.006

文献信息

• BLOCK POLYMERS, COMPOSITIONS AND METHODS FOR USE FOR FOAMS, LAUNDRY DETERGENTS, AND SHOWER RINSES AND COAGULANTS
  申请人：YEUNG Dominic Wai-Kwing

  公开号：US20110183852A1

  公开（公告）日：2011-07-28

  The present invention relates to a block polymeric material. Typically the block polymer comprises units capable of having an average cationic charge density of about 15 or less, preferably 5 or less, more preferably from about 0.05 to about 5, even more preferably from about 0.05 to about 2.77, even more preferably from about 0.1 to about 2.75, most preferably from about 0.75 to about 2.25 units per 100 daltons molecular weight at a pH of from about 4 to about 12. The polymeric material is a suds enhancer and a suds volume extender for personal care products such as soaps and shampoos. The compositions have increased effectiveness for preventing re-deposition of grease during hand and body washing. The polymers are also effective as a soil release agent in fabric cleaning compositions. The polymeric material is also effective in oil well treating foam, fire-fighting foam, hard surface cleaning foam, shaving cream, post-foaming shaving gel, dephiliatories and as a coagulant/retention aid for titanium dioxide in paper making.
• POLYMERS, COMPOSITIONS AND METHODS FOR USE FOR FOAMS, LAUNDRY DETERGENTS, SHOWER RINSES AND COAGULANTS
  申请人：BERGERON Vance

  公开号：US20110257015A1

  公开（公告）日：2011-10-20

  The present invention relates to a polymeric material comprising units capable of having a cationic charge at a pH of from about 4 to about 12; provided that said polymeric material has an average cationic charge density from about 2.75 or less units per 100 daltons molecular weight at a pH of from about 4 to about 12. The polymeric material is a suds enhancer and a suds volume extender for hand dishwashing compositions and personal care products such as soaps, shaving cream foam, foaming shaving gel, foam dephiliatories and shampoos. The polymers are also effective as a soil release agent in fabric cleaning compositions. The polymers are also useful in agrochemical foam, fire-fighting foam, hard surface cleaner foam, and coagulant for titanium dioxide in paper making.
• POLYMERS, COMPOSITIONS AND METHODS OF USE FOR FOAMS, LAUNDRY DETERGENTS, SHOWER RINSES AND COAGULANTS
  申请人：RHODIA INC.

  公开号：US20130237471A1

  公开（公告）日：2013-09-12

  The present invention relates to a polymeric material comprising units capable of having a cationic charge at a pH of from about 4 to about 12; provided that said polymeric material has an average cationic charge density from about 2.75 or less units per 100 daltons molecular weight at a pH of from about 4 to about 12. The polymeric material is a suds enhancer and a suds volume extender for hand dishwashing compositions and personal care products such as soaps, shaving cream foam, foaming shaving gel, foam dephiliatories and shampoos. The polymers are also effective as a soil release agent in fabric cleaning compositions. The polymers are also useful in agrochemical foam, fire-fighting foam, hard surface cleaner foam, and coagulant for titanium dioxide in paper making.
• NOVEL AZOBENZENE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR THERAPEUTIC TREATMENT ASSOCIATED WITH IONIZING RADIATIONS
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20220125923A1

  公开（公告）日：2022-04-28

  The present invention relates to new ionizing radiation-activatable derivatives, their preparation process and their therapeutic uses.
• US8188204B2
  申请人：——

  公开号：US8188204B2

  公开（公告）日：2012-05-29

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