2-Oxa-bicyclo-(2,2,2)-oktano-3,3-dicarbonsaeure-diaethylester | 61779-31-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 2-Oxa-bicyclo-(2,2,2)-oktano-3,3-dicarbonsaeure-diaethylester
• 英文别名: 2-oxa-bicyclo[2.2.2]octane-3,3-dicarboxylic acid diethyl ester；2-Oxabicyclo[2.2.2]octane-3,3-dicarboxylic acid, diethyl ester；diethyl 2-oxabicyclo[2.2.2]octane-3,3-dicarboxylate
• CAS: 61779-31-5
• 化学式: C₁₃H₂₀O₅
• 分子量: 256.299
• InChiKey: SFPNKHIKMRMXFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Oxa-bicyclo-(2,2,2)-oktano-3,3-dicarbonsaeure-diaethylester 、 甲醇 、 氢氧化钾 生成 2-Oxabicyclo[2.2.2]octane-3,3-dicarboxylic acid
  参考文献：
  名称：

  ACHAMATOWICZ JR. O.; JURCZAK J.; PYREK J. S., TETRAHEDRON , 1976, 32, NO 17, 2113-2115

  摘要：

  DOI：
• 作为产物：
  描述：

  (1S,4R)-2-oxa-3,3-diethoxycarbonylbicyclo[2.2.2]oct-5-ene 以53%的产率得到
  参考文献：
  名称：

  ACHAMATOWICZ JR. O.; JURCZAK J.; PYREK J. S., TETRAHEDRON , 1976, 32, NO 17, 2113-2115

  摘要：

  DOI：

文献信息

• [EN] HEPATITIS C VIRUS INHIBITORS<br/>[FR] INHIBITEURS DU VIRUS DE L'HÉPATITE C
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2017023631A1

  公开（公告）日：2017-02-09

  The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

  本公开涉及抗病毒化合物，更具体地涉及可以抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白功能的化合物组合，包括这种组合的组成物，以及抑制NS5A蛋白功能的方法。
• Hepatitis C virus inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10617675B2

  公开（公告）日：2020-04-14

  The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

  本公开内容一般涉及抗病毒化合物，更具体地涉及可抑制丙型肝炎病毒（HCV）编码的 NS5A 蛋白功能的化合物组合、包含此类组合的组合物以及抑制 NS5A 蛋白功能的方法。
• HEPATITIS C VIRUS INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20180221342A1

  公开（公告）日：2018-08-09

  The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
• ACHAMATOWICZ JR. O.; JURCZAK J.; PYREK J. S., TETRAHEDRON <TETR-AB>, 1976, 32, NO 17, 2113-2115
  作者：ACHAMATOWICZ JR. O.、 JURCZAK J.、 PYREK J. S.

  DOI：——

  日期：——