N'-(3-phenyl-propyl)-hydrazinecarboxylic acid t-butyl ester | 187026-83-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-(3-phenyl-propyl)-hydrazinecarboxylic acid t-butyl ester
• 英文别名: tert-butyl N-(3-phenylpropylamino)carbamate
• CAS: 187026-83-1
• 化学式: C₁₄H₂₂N₂O₂
• 分子量: 250.341
• InChiKey: ZUDCEWRJJGQCEK-UHFFFAOYSA-N

物化性质

• 密度：
  1.032±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N'-(3-phenyl-propyl)-hydrazinecarboxylic acid t-butyl ester 以 N,N-二甲基甲酰胺 为溶剂， 生成 3-Benzyl-1-[N'-tert-butoxycarbonyl-N-(3-phenyl-propyl)-hydrazinocarbonyl]-piperidine-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  由受阻胺合成氮杂肽，导致新型生长激素促分泌素

  摘要：

  当使用受阻胺时，使用已知的制备氮杂肽的方法不能成功制备已知有效生长激素促分泌素（GHS）的氮杂类似物。现在，我们报告使用双五氟碳酸苯酯作为“平衡反应性”光气等同物的偶联方法，以解决这些问题。

  DOI：

  10.1016/s0040-4039(99)01888-2
• 作为产物：
  描述：

  肼基甲酸叔丁酯 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 甲醇 、 正己烷 为溶剂， 反应 8.0h， 生成 N'-(3-phenyl-propyl)-hydrazinecarboxylic acid t-butyl ester
  参考文献：
  名称：

  Iridium-catalyzed selective N-allylation of hydrazines

  摘要：

  A highly chemo- and regioselective iridium-catalyzed allylic amination is described. The reaction of various hydrazones and hydrazides with allylic carbonates proceeds at ambient temperature in the presence of an [Ir(COD)Cl](2)/pyridine catalyst, ammonium iodide. and diethylzinc to afford the corresponding N-allylation products in high yields with excellent chemo- and regioselectivities. Only the more nucleophilic nitrogen of a given hydrazine, derivative undergoes the C-N bond formation to yield a branched allylic isomer as the exclusive product. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.105

文献信息

• A novel and efficient synthesis of 2,5-substituted 1,2,4-triazol-3-ones
  作者：James Zhengwu Deng、Christopher S. Burgey

  DOI：10.1016/j.tetlet.2005.09.073

  日期：2005.11

  A novel procedure for preparing 1,2,4-triazol-3-ones is described. Various alkyl, aryl, and heterocyclic groups were introduced successfully at both the N2 and C5 positions. The triazolone ring was constructed through an intramolecular cyclization of a novel acyclic precursor, which in turn was synthesized by treating a mono protected hydrazine with an acyl isocyanate. Under conditions that remove the hydrazine protecting group, the intramolecular cyclization occurs rapidly, to deliver the 2,5-substituted 1,2,4-triazol-3-ones in excellent yields (79-99%) without column purification. (c) 2005 Elsevier Ltd. All rights reserved.
• US6214826B1
  申请人：——

  公开号：US6214826B1

  公开（公告）日：2001-04-10
• Iridium-catalyzed selective N-allylation of hydrazines
  作者：Robert Matunas、Amy J. Lai、Chulbom Lee

  DOI：10.1016/j.tet.2005.03.105

  日期：2005.6

  A highly chemo- and regioselective iridium-catalyzed allylic amination is described. The reaction of various hydrazones and hydrazides with allylic carbonates proceeds at ambient temperature in the presence of an [Ir(COD)Cl](2)/pyridine catalyst, ammonium iodide. and diethylzinc to afford the corresponding N-allylation products in high yields with excellent chemo- and regioselectivities. Only the more nucleophilic nitrogen of a given hydrazine, derivative undergoes the C-N bond formation to yield a branched allylic isomer as the exclusive product. (c) 2005 Elsevier Ltd. All rights reserved.
• Synthesis of azapeptides from hindered amines leading to novel growth hormone secretagogues
  作者：Thomas Kruse Hansen

  DOI：10.1016/s0040-4039(99)01888-2

  日期：1999.12

  Preparations of aza analogues of known potent growth hormone secretagogues (GHS) were unsuccessful using known methods for preparation of azapeptides when hindered amines were employed. We now report a coupling method using bispentafluorophenylcarbonate as a “balanced reactivity” phosgene equivalent to solve these problems.

  当使用受阻胺时，使用已知的制备氮杂肽的方法不能成功制备已知有效生长激素促分泌素（GHS）的氮杂类似物。现在，我们报告使用双五氟碳酸苯酯作为“平衡反应性”光气等同物的偶联方法，以解决这些问题。