Trimethyl-[4-(trifluoromethyl)-6-trimethylsilyloxypyrimidin-2-yl]oxysilane | 145663-04-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Trimethyl-[4-(trifluoromethyl)-6-trimethylsilyloxypyrimidin-2-yl]oxysilane
• CAS: 145663-04-3
• 化学式: C₁₁H₁₉F₃N₂O₂Si₂
• 分子量: 324.45
• InChiKey: QFNLHKCOBBHLSQ-UHFFFAOYSA-N

物化性质

• 沸点：
  281.1±50.0 °C(predicted)
• 密度：
  1.100±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.92
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Trimethyl-[4-(trifluoromethyl)-6-trimethylsilyloxypyrimidin-2-yl]oxysilane 在 水 作用下， 以 1,1,2-三氯三氟乙烷（CFC-113） 、 乙酸乙酯 为溶剂， 反应 5.5h， 生成 5-(1,1,2,2,3,3,3-heptafluoropropyl)-6-(trifluoromethyl)-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Facile perfluoroalkylation of uracils and uridines at the C-5 position

  摘要：

  Perfluoroalkylation at the C-5 position of uracil has been achieved in yields of 38-56% by the reaction of its bis(trimethylsilyl) derivative with bis(perfluoroalkanoyl) peroxides and the hydrolytic deprotection of the silylated products. A substituent or nitrogen replacement at C-6 does not interfere with perfluoroalkylation at C-5, but no significant reaction occurs at C-6 when C-5 is blocked.

  DOI：

  10.1016/s0022-1139(00)80396-6
• 作为产物：
  描述：

  三甲基氯硅烷 、 6-(三氟甲基)尿嘧啶 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 15.0h， 生成 Trimethyl-[4-(trifluoromethyl)-6-trimethylsilyloxypyrimidin-2-yl]oxysilane
  参考文献：
  名称：

  Facile perfluoroalkylation of uracils and uridines at the C-5 position

  摘要：

  Perfluoroalkylation at the C-5 position of uracil has been achieved in yields of 38-56% by the reaction of its bis(trimethylsilyl) derivative with bis(perfluoroalkanoyl) peroxides and the hydrolytic deprotection of the silylated products. A substituent or nitrogen replacement at C-6 does not interfere with perfluoroalkylation at C-5, but no significant reaction occurs at C-6 when C-5 is blocked.

  DOI：

  10.1016/s0022-1139(00)80396-6

文献信息

• Facile perfluoroalkylation of uracils and uridines at the C-5 position
  作者：Masakazu Nishida、Shozo Fujii、Hiroshi Kimoto、Yoshio Hayakawa、Hideo Sawada、Louis A. Cohen

  DOI：10.1016/s0022-1139(00)80396-6

  日期：1993.7

  Perfluoroalkylation at the C-5 position of uracil has been achieved in yields of 38-56% by the reaction of its bis(trimethylsilyl) derivative with bis(perfluoroalkanoyl) peroxides and the hydrolytic deprotection of the silylated products. A substituent or nitrogen replacement at C-6 does not interfere with perfluoroalkylation at C-5, but no significant reaction occurs at C-6 when C-5 is blocked.