1,4-bis(5,5-dipropionylpentyloxy)benzene | 66619-81-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,4-bis(5,5-dipropionylpentyloxy)benzene
• 英文别名: 4-[4-[4-(6-Oxo-5-propanoyl-octoxy)phenoxy]butyl]heptane-3,5-dione；4-[4-[4-(6-oxo-5-propanoyloctoxy)phenoxy]butyl]heptane-3,5-dione
• CAS: 66619-81-6
• 化学式: C₂₈H₄₂O₆
• 分子量: 474.638
• InChiKey: DLUBNXABZGPVPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  34
• 可旋转键数：
  20
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,4-双(4-溴丁氧基)苯 以24%的产率得到
  参考文献：
  名称：

  DIANA G. D.; CARABATEAS P. M.; SALVADOR U. J.; WILLIAMS G. L.; ZALAY E. S+, J. MED. CHEM., 1978, 21, NO 7, 689-692

  摘要：

  DOI：

文献信息

• Arylenedioxy-bis-diketones
  申请人：Sterling Drug Inc.

  公开号：US04096280A1

  公开（公告）日：1978-06-20

  Phenylenedioxy-bis-dikeones having the formula ##STR1## useful as antiviral agents, are prepared by etherification of dihydric phenols and alkylation of beta-dikeones.

  具有以下化学式的苯二酚双酮##STR1## 的化合物可用作抗病毒剂，其制备方法为通过二元醚化反应制备二元醚苯酚，再通过β-二酮烷基化反应制备。
• Antiviral activity of some .beta.-diketones. 3. Aryl bis(.beta.-diketones). Antiherpetic activity
  作者：Guy D. Diana、Philip M. Carabateas、U. Joseph Salvador、Gordon L. Williams、Ethel S. Zalay、Francis Pancic、B. A. Steinberg、Joseph C. Collins

  DOI：10.1021/jm00205a019

  日期：1978.7

  A series of bis(beta-diketones) was synthesized and tested in vitro for antiviral actitity against herpes simplex type 2. Two parameters which were studied in an effort to optimize activity were the nature of the aryl group and the length of the alkyl bridge. One of the more active compounds, 4,4'-[(1,4-phenylenedioxy)bis(6,1-hexanediyl)]-bis[3,5-heptanedione] (6), was evaluated more extensively and found to inhibit the cytopathic effect in tissue culture of herpes simplex virus type 1 as well as type 2. Compound 6 was evaluated in vivo topically against herpes simplex type 1 in experimentally induced skin infections in guinea pigs. A topical treatment with 2% of 6 in a vanishing cream base, administered 24 h postinfection applied five times daily for 4 days, significantly reduced the number and size of herpetic vesicles.
• US4096280A
  申请人：——

  公开号：US4096280A

  公开（公告）日：1978-06-20