1,7-dioxaspiro[5.6]dodecane | 181-25-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: 1,7-dioxaspiro[5.6]dodecane
• 英文别名: 1,7-dioxa-spiro[5.6]dodecane；1,7-Dioxa-spiro[5.6]dodecan；1,12-dioxaspiro[5.6]dodecane
• CAS: 181-25-9
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: DSBZEBGTDAPRJV-UHFFFAOYSA-N

物化性质

• 沸点：
  97 °C(Press: 12 Torr)
• 密度：
  1.0073 g/cm3
• 熔点：
  13 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,7-dioxaspiro[5.6]dodecane 在 水 、 氢溴酸 作用下， 生成 1,10-dibromo-decan-5-one
  参考文献：
  名称：

  Stetter; Rauhut, Chemische Berichte, 1958, vol. 91, p. 2543,2547

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(2,6-dioxo-cyclohexyl)-butyric acid methyl ester 在 四氢呋喃 、 盐酸 、 lithium aluminium tetrahydride 、 硫酸 、 对甲苯磺酸 、 Petroleum ether 、 苯 作用下， 生成 1,7-dioxaspiro[5.6]dodecane
  参考文献：
  名称：

  Stetter; Rauhut, Chemische Berichte, 1958, vol. 91, p. 2543,2547

  摘要：

  DOI：

文献信息

• Highly efficient catalytic routes to spiroketal motifs
  作者：Selvasothi Selvaratnam、Joanne H.H. Ho、Paul B. Huleatt、Barbara A. Messerle、Christina L.L. Chai

  DOI：10.1016/j.tetlet.2008.12.075

  日期：2009.3

  The versatile and efficient synthesis of a variety of spiroketal motifs via the double intramolecular hydroalkoxylation of aliphatic and aromatic alkyne diols was achieved using simple and readily accessible Ir(I) and Rh(I) cyclooctadiene complexes as catalysts.

  通过使用简单易得的Ir（I）和Rh（I）环辛二烯络合物作为催化剂，通过脂肪族和芳香族炔二醇的双分子内加氢烷氧基化，可以实现多种螺环基序化合物的通用和高效合成。
• SLOW-RELEASE FORMULATION CONTAINING GEL COMPOSITION FOR USE ON PESTS
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP2805615A1

  公开（公告）日：2014-11-26

  Provided is a sustained release preparation comprising an insect pest-targeting gel composition, the preparation being free from leakage or reaction of a volatile substance and being capable of releasing the volatile substance at a constant rate. More specifically, provided is a sustained release preparation comprising a polymer tube and an insect pest-targeting gel composition in the polymer tube, the composition comprising one or more volatile substances and an oil gelling agent, wherein the volatile substances are comprised in an amount of from 70.0 to 99.0% by weight by the insect pest-targeting composition and are released outside of the polymer tube through the polymer tube.

  本发明提供了一种包含害虫靶向凝胶组合物的缓释制剂，该制剂中的挥发性物质不会泄漏或发生反应，并且能够以恒定的速率释放挥发性物质。更具体地说，本发明提供了一种持续释放制剂，包括聚合物管和聚合物管中的害虫靶向凝胶组合物，该组合物包括一种或多种挥发性物质和油胶凝剂，其中挥发性物质的含量为害虫靶向组合物重量的 70.0% 至 99.0%，并通过聚合物管释放到聚合物管外。
• Insect pest-targeting gel composition and sustained release preparation comprising that
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US10244750B2

  公开（公告）日：2019-04-02

  Provided are an insect pest-targeting gel composition causing neither leakage nor reaction of a volatile substance and capable of releasing the volatile substance at a constant rate; and a sustained release preparation including the insect pest-targeting gel composition. More specifically, provided is an insect pest-targeting gel composition including one or more volatile substances and an oil gelling agent, wherein the volatile substance is included in an amount of from 70.0 to 99.0% by weight by the insect pest-targeting gel composition.

  本发明提供了一种害虫靶向凝胶组合物，该组合物不会导致挥发性物质泄漏或反应，并能以恒定速率释放挥发性物质；还提供了一种包含该害虫靶向凝胶组合物的缓释制剂。更具体地说，提供了一种包含一种或多种挥发性物质和油胶凝剂的害虫靶向凝胶组合物，其中挥发性物质的含量为害虫靶向凝胶组合物重量的 70.0% 至 99.0%。
• Mudryk, Boguslaw; Shook, Craig A.; Cohen, Theodore, Journal of the American Chemical Society, 1990, vol. 112, # 17, p. 6389 - 6391
  作者：Mudryk, Boguslaw、Shook, Craig A.、Cohen, Theodore

  DOI：——

  日期：——
• Alkynyltrifluoroborates as Versatile Tools in Organic Synthesis:  A New Route to Spiroketals
  作者：Jan Doubský、Ludvík Streinz、David Šaman、Jiří Zedník、Bohumír Koutek

  DOI：10.1021/ol047987k

  日期：2004.12.1

  A simple and efficient two-step approach to spiroketals is described. Key steps include the preparation of functionalized hydroxyl alpha-alkynones by ring-opening reactions of lactones with lithium alkynyltrifluoroborates followed by a palladium-catalyzed hydrogenation/spirocyclization of the prespiroketal intermediate.