methyl 7-oxabicyclo<2.2.1>heptane-2-carboxylate | 21987-32-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢呋喃
• 英文名称: methyl 7-oxabicyclo<2.2.1>heptane-2-carboxylate
• 英文别名: 7-oxa-2-(carbomethoxy)bicyclo<2.2.1>heptane；7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid methyl ester；exo-7-oxabicyclo-[2.2.1]-heptan-2-carboxylic-acid,methylester；methyl 7-oxa-2-norbornanecarboxylate；methyl 7-oxabicyclo[2.2.1]heptane-2-carboxylate
• CAS: 21987-32-6
• 化学式: C₈H₁₂O₃
• mdl: MFCD27980660
• 分子量: 156.181
• InChiKey: UYMKMUZNHJKUQB-UHFFFAOYSA-N

物化性质

• 沸点：
  205.0±13.0 °C(Predicted)
• 密度：
  1.166±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 7-oxabicyclo<2.2.1>heptane-2-carboxylate 在 盐酸 、 sodium hydroxide 作用下， 反应 2.5h， 生成 7-氧杂二环[2.2.1]庚烷-3-羧酸
  参考文献：
  名称：

  电子需求增加引起的氧气参与

  摘要：

  Le dibrosylate du cis,endo-oxa-7bicyclo [2.2.1] heptanediol-2,3 s'acetolyse 加快速反应 que 子异构体。Dans la serie monobrosylate 通讯员，l'isomere exo s'acetolyse plus rapidement que l'isomere exo

  DOI：

  10.1021/ja00311a053
• 作为产物：
  描述：

  methyl 7-oxabicyclo<2.2.1>hept-5-ene-endo-2-carboxylate 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 以89%的产率得到methyl 7-oxabicyclo<2.2.1>heptane-2-carboxylate
  参考文献：
  名称：

  电子需求增加引起的氧气参与

  摘要：

  Le dibrosylate du cis,endo-oxa-7bicyclo [2.2.1] heptanediol-2,3 s'acetolyse 加快速反应 que 子异构体。Dans la serie monobrosylate 通讯员，l'isomere exo s'acetolyse plus rapidement que l'isomere exo

  DOI：

  10.1021/ja00311a053

文献信息

• On the lewis acid catalyzed diels-alder reaction of furan. regio- and stereospecific synthesis of substituted cyclohexenols and cyclohexadienols.
  作者：Francis Brion

  DOI：10.1016/s0040-4039(00)85823-2

  日期：1982.1

  The [4+2] cycloaddition between furan and some dienophiles can be greatly accelerated in the presence of a Lewis-Acid (i.e. ZnI2. The 7-oxabicyclo [2.2.1] heptyl system readily undergoes a base promoted β-elimination of the heteroatom bridge leading to substituted cyclohexenols and cyclohexadienols.

  在存在路易斯酸（即ZnI 2）的情况下，呋喃和一些亲二烯体之间的[4 + 2]环加成反应可以大大加速。7-氧杂双环[2.2.1]庚基系统容易进行碱促进的β-消除。杂原子桥导致取代的环己醇和环己烯醇。
• Oxygen participation induced by increased electron demand
  作者：Joseph B. Lambert、Eric G. Larson

  DOI：10.1021/ja00311a053

  日期：1985.12

  Le dibrosylate du cis,endo-oxa-7bicyclo [2.2.1] heptanediol-2,3 s'acetolyse plus rapidement que son isomere diexo. Dans la serie monobrosylate correspondante, l'isomere exo s'acetolyse plus rapidement que l'isomere exo

  Le dibrosylate du cis,endo-oxa-7bicyclo [2.2.1] heptanediol-2,3 s'acetolyse 加快速反应 que 子异构体。Dans la serie monobrosylate 通讯员，l'isomere exo s'acetolyse plus rapidement que l'isomere exo
• Novel ester compounds, polymers, resist compositions and patterning process
  申请人：——

  公开号：US20040068124A1

  公开（公告）日：2004-04-08

  Novel ester compounds having formula (1) wherein A 1 is a polymerizable functional group having a double bond, A 2 is furandiyl, tetrahydrofurandiyl or oxanorbornanediyl, R 1 and R 2 each are a monovalent hydrocarbon group, or R 1 and R 2 may bond together to form an aliphatic hydrocarbon ring with the carbon atom, and R 3 is hydrogen or a monovalent hydrocarbon group which may contain a hetero atom are polymerizable into polymers. Resist compositions comprising the polymers are sensitive to high-energy radiation, have an improved sensitivity, resolution, and etching resistance, and lend themselves to micropatterning with electron beams or deep-UV rays. 1

  具有式（1）的新型酯化合物，其中A1是具有双键的可聚合官能团，A2是呋喃基，四氢呋喃基或氧杂-去氢萘二基，R1和R2分别是一价碳氢基团，或者R1和R2可以结合形成带有碳原子的脂肪族碳氢环，R3是氢或可以含有杂原子的一价碳氢基团，可以聚合成聚合物。包含这些聚合物的抗蚀剂组合物对高能辐射敏感，具有改善的敏感性、分辨率和蚀刻抗性，并且适用于使用电子束或深紫外线进行微图案制作。
• Ester compounds, polymers, resist compositions and patterning process
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US07132215B2

  公开（公告）日：2006-11-07

  Novel ester compounds having formula (1) wherein A1 is a polymerizable functional group having a double bond, A2 is furandiyl, tetrahydrofurandiyl or oxanorbornanediyl, R1 and R2 each are a monovalent hydrocarbon group, or R1 and R2 may bond together to form an aliphatic hydrocarbon ring with the carbon atom, and R3 is hydrogen or a monovalent hydrocarbon group which may contain a hetero atom are polymerizable into polymers. Resist compositions comprising the polymers are sensitive to high-energy radiation, have an improved sensitivity, resolution, and etching resistance, and lend themselves to micropatterning with electron beams or deep-UV rays.

  具有式（1）的新型酯化合物，其中A1是具有双键的可聚合官能团，A2是呋喃基，四氢呋喃基或氧杂莽环基，R1和R2各自是一价的碳氢基团，或者R1和R2可以结合形成带有碳原子的脂肪族碳氢环，R3是氢或者可能含有杂原子的一价碳氢基团，可以聚合成聚合物。含有这些聚合物的抗蚀剂组合物对高能辐射敏感，具有更好的敏感度、分辨率和蚀刻抵抗性，并适用于电子束或深紫外线微细图案化。
• Antiinflammatory benzoxazolones
  申请人：PFIZER INC.

  公开号：EP0385664A2

  公开（公告）日：1990-09-05

  This invention relates to certain benzoxazolinones which inhibit lipoxygenase and/or cyclooxygenase en-Ozymes. Such compounds are useful in inhibiting such enzymes, per se, and are useful in treating allergic and inflammatory conditions in a mammal. This invention also relates to methods of inhibiting lipoxygenase and/or cyclooxygenase in a mammal with such benzoxazolinones; methods of treating an allergic condition in a mammal with such compounds; methods of treating an inflammatory condition in a mammal with such compounds; and pharmaceutical compositions comprising the benzoxazolinones hereof.

  本发明涉及某些抑制脂氧合酶和/或环氧合酶的苯并恶唑啉酮类化合物。此类化合物本身可用于抑制此类酶，并可用于治疗哺乳动物的过敏和炎症。本发明还涉及用此类苯并噁唑啉酮抑制哺乳动物体内脂氧合酶和/或环氧合酶的方法；用此类化合物治疗哺乳动物过敏性疾病的方法；用此类化合物治疗哺乳动物炎症性疾病的方法；以及包含本发明苯并噁唑啉酮的药物组合物。