methyl 7-oxabicyclo<2.2.1>heptane-2-carboxylate | 21987-32-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢呋喃
• 英文名称: methyl 7-oxabicyclo<2.2.1>heptane-2-carboxylate
• 英文别名: 7-oxa-2-(carbomethoxy)bicyclo<2.2.1>heptane；7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid methyl ester；exo-7-oxabicyclo-[2.2.1]-heptan-2-carboxylic-acid,methylester；methyl 7-oxa-2-norbornanecarboxylate；methyl 7-oxabicyclo[2.2.1]heptane-2-carboxylate
• CAS: 21987-32-6
• 化学式: C₈H₁₂O₃
• mdl: MFCD27980660
• 分子量: 156.181
• InChiKey: UYMKMUZNHJKUQB-UHFFFAOYSA-N

物化性质

• 沸点：
  205.0±13.0 °C(Predicted)
• 密度：
  1.166±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 7-oxabicyclo<2.2.1>heptane-2-carboxylate 在 盐酸 、 sodium hydroxide 作用下， 反应 2.5h， 生成 7-氧杂二环[2.2.1]庚烷-3-羧酸
  参考文献：
  名称：

  电子需求增加引起的氧气参与

  摘要：

  Le dibrosylate du cis,endo-oxa-7bicyclo [2.2.1] heptanediol-2,3 s'acetolyse 加快速反应 que 子异构体。Dans la serie monobrosylate 通讯员，l'isomere exo s'acetolyse plus rapidement que l'isomere exo

  DOI：

  10.1021/ja00311a053
• 作为产物：
  描述：

  methyl 7-oxabicyclo<2.2.1>hept-5-ene-endo-2-carboxylate 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 以89%的产率得到methyl 7-oxabicyclo<2.2.1>heptane-2-carboxylate
  参考文献：
  名称：

  电子需求增加引起的氧气参与

  摘要：

  Le dibrosylate du cis,endo-oxa-7bicyclo [2.2.1] heptanediol-2,3 s'acetolyse 加快速反应 que 子异构体。Dans la serie monobrosylate 通讯员，l'isomere exo s'acetolyse plus rapidement que l'isomere exo

  DOI：

  10.1021/ja00311a053

文献信息

• On the lewis acid catalyzed diels-alder reaction of furan. regio- and stereospecific synthesis of substituted cyclohexenols and cyclohexadienols.
  作者：Francis Brion

  DOI：10.1016/s0040-4039(00)85823-2

  日期：1982.1

  The [4+2] cycloaddition between furan and some dienophiles can be greatly accelerated in the presence of a Lewis-Acid (i.e. ZnI2. The 7-oxabicyclo [2.2.1] heptyl system readily undergoes a base promoted β-elimination of the heteroatom bridge leading to substituted cyclohexenols and cyclohexadienols.

  在存在路易斯酸（即ZnI 2）的情况下，呋喃和一些亲二烯体之间的[4 + 2]环加成反应可以大大加速。7-氧杂双环[2.2.1]庚基系统容易进行碱促进的β-消除。杂原子桥导致取代的环己醇和环己烯醇。
• Novel ester compounds, polymers, resist compositions and patterning process
  申请人：——

  公开号：US20040068124A1

  公开（公告）日：2004-04-08

  Novel ester compounds having formula (1) wherein A 1 is a polymerizable functional group having a double bond, A 2 is furandiyl, tetrahydrofurandiyl or oxanorbornanediyl, R 1 and R 2 each are a monovalent hydrocarbon group, or R 1 and R 2 may bond together to form an aliphatic hydrocarbon ring with the carbon atom, and R 3 is hydrogen or a monovalent hydrocarbon group which may contain a hetero atom are polymerizable into polymers. Resist compositions comprising the polymers are sensitive to high-energy radiation, have an improved sensitivity, resolution, and etching resistance, and lend themselves to micropatterning with electron beams or deep-UV rays. 1

  具有式（1）的新型酯化合物，其中A1是具有双键的可聚合官能团，A2是呋喃基，四氢呋喃基或氧杂-去氢萘二基，R1和R2分别是一价碳氢基团，或者R1和R2可以结合形成带有碳原子的脂肪族碳氢环，R3是氢或可以含有杂原子的一价碳氢基团，可以聚合成聚合物。包含这些聚合物的抗蚀剂组合物对高能辐射敏感，具有改善的敏感性、分辨率和蚀刻抗性，并且适用于使用电子束或深紫外线进行微图案制作。
• Ester compounds, polymers, resist compositions and patterning process
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US07132215B2

  公开（公告）日：2006-11-07

  Novel ester compounds having formula (1) wherein A1 is a polymerizable functional group having a double bond, A2 is furandiyl, tetrahydrofurandiyl or oxanorbornanediyl, R1 and R2 each are a monovalent hydrocarbon group, or R1 and R2 may bond together to form an aliphatic hydrocarbon ring with the carbon atom, and R3 is hydrogen or a monovalent hydrocarbon group which may contain a hetero atom are polymerizable into polymers. Resist compositions comprising the polymers are sensitive to high-energy radiation, have an improved sensitivity, resolution, and etching resistance, and lend themselves to micropatterning with electron beams or deep-UV rays.

  具有式（1）的新型酯化合物，其中A1是具有双键的可聚合官能团，A2是呋喃基，四氢呋喃基或氧杂莽环基，R1和R2各自是一价的碳氢基团，或者R1和R2可以结合形成带有碳原子的脂肪族碳氢环，R3是氢或者可能含有杂原子的一价碳氢基团，可以聚合成聚合物。含有这些聚合物的抗蚀剂组合物对高能辐射敏感，具有更好的敏感度、分辨率和蚀刻抵抗性，并适用于电子束或深紫外线微细图案化。
• Antiinflammatory benzoxazolones
  申请人：PFIZER INC.

  公开号：EP0385664A2

  公开（公告）日：1990-09-05

  This invention relates to certain benzoxazolinones which inhibit lipoxygenase and/or cyclooxygenase en-Ozymes. Such compounds are useful in inhibiting such enzymes, per se, and are useful in treating allergic and inflammatory conditions in a mammal. This invention also relates to methods of inhibiting lipoxygenase and/or cyclooxygenase in a mammal with such benzoxazolinones; methods of treating an allergic condition in a mammal with such compounds; methods of treating an inflammatory condition in a mammal with such compounds; and pharmaceutical compositions comprising the benzoxazolinones hereof.

  本发明涉及某些抑制脂氧合酶和/或环氧合酶的苯并恶唑啉酮类化合物。此类化合物本身可用于抑制此类酶，并可用于治疗哺乳动物的过敏和炎症。本发明还涉及用此类苯并噁唑啉酮抑制哺乳动物体内脂氧合酶和/或环氧合酶的方法；用此类化合物治疗哺乳动物过敏性疾病的方法；用此类化合物治疗哺乳动物炎症性疾病的方法；以及包含本发明苯并噁唑啉酮的药物组合物。
• Substituted acrylamido-penicillanic acid derivatives
  申请人：Beecham Group p.l.c.

  公开号：EP0421752A2

  公开（公告）日：1991-04-10

  Compounds of formula (I) and their derivatives: wherein X is hydrogen or a group NHR¹, wherein R¹ is hydrogen or an amino protecting group, and R is an optionally substituted spiro, fused or bridged bicyclic group optionally containing one or more heteroatoms selected from oxygen, nitrogen and sulphur, are new and useful in the treatment of bacterial infections in humans and animals.

  式(I)化合物及其衍生物： 其中 X 是氢或基团 NHR¹，其中 R¹ 是氢或氨基保护基团，R 是任选取代的螺环、融合或桥接双环基团，任选含有一个或多个选自氧、氮和硫的杂原子，这些化合物是治疗人类和动物细菌感染的新型有用药物。