3-(1-羟基庚基)-4-(羟基甲基)四氢呋喃-2-酮 | 125761-52-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 3-(1-羟基庚基)-4-(羟基甲基)四氢呋喃-2-酮
• 中文别名: 2-氨基-N-[2-[[2-(1,3-二甲基丁基氨基)-2-羰基-乙基]氨基]-1-甲基-2-羰基-乙基]-3-(4-羟基苯基)丙酰胺
• 英文名称: 3-(1-Hydroxyheptyl)-4-(hydroxymethyl)oxolan-2-one
• CAS: 125761-52-6
• 化学式: C₁₂H₂₂O₄
• 分子量: 230.3
• InChiKey: JWZVDINGVWOBKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-heptanoyl-4-(hydroxymethyl)dihydrofuran-2(3H)-one 、 硼氢化钠 以4%的产率得到
  参考文献：
  名称：

  NIHIRA, TAKUYA;SHIMIZU, YOSHIHIRO;KIM, HYUN SOO;YAMADA, YASUHIRO, J. ANTIBIOTICS, 41,(1988) N2, C. 1828-1837

  摘要：

  DOI：

文献信息

• Compositions and methods for activation and overexpression of secondary metabolites in microorganisms
  申请人：Prospective Research, Inc.

  公开号：US20180346871A1

  公开（公告）日：2018-12-06

  Methods and compositions herein provide non-naturally occurring γ-butyrolactones (GBLs) in racemic mixtures that increase efficiency and effectiveness of screening for production of antibiotics, and enhance yields and express silent pathways. Non-naturally occurring GBLs were synthesized and found to stimulate antibiotic production in several different streptomycete strains. Antibiotic production by Streptomyces coelicolor was induced by a racemic mixture of non-cognate stereoisomers of VB-D, seven of which are non-naturally occurring. Further, novel A-factor-type GBL analogs stimulated antibiotic production in S. coelicolor . Synthesis in response to the treatment with the non-cognates GBL was observed for known compounds including undecylprodigiosin, desferrioxamine and streptorubin B, as was synthesis of a compound of unknown structure. A group of 37 additional microbial strains was screened by principal component analysis to determine optimal concentrations of each of a panel of four non-cognate synthetic GBLs for addition to cultures with optimal stimulation of secondary metabolites, and large scale fermentations were analyzed and product enhancement by the GBLs was observed.

  本文提供的方法和组合物提供了非自然存在的γ-丁内酯（GBLs）的混合物，可增加筛选生产抗生素的效率和有效性，并增强产量和表达沉默途径。已合成非自然存在的GBLs，并发现它们能刺激几种不同链霉菌菌株的抗生素产生。通过非同源立体异构体VB-D的混合物（其中七种非自然存在）可以诱导链霉菌共色素的抗生素产生。此外，新型A因子型GBL类似物刺激了S. coelicolor的抗生素产生。已知化合物，包括十一烷基紫质素，去铁蛋白和链霉红素B，以及一种未知结构的化合物，对非同源GBL的处理作出了合成反应。通过主成分分析筛选了37个额外的微生物菌株，以确定每种四种非同源合成GBL的最佳浓度，以优化次生代谢物的刺激，并对大规模发酵进行了分析，观察到GBLs的产物增强效果。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：ENEVOLV, INC.

  公开号：US20160186168A1

  公开（公告）日：2016-06-30

  The present disclosure provides compositions and methods for genomic engineering.
• US9944925B2
  申请人：——

  公开号：US9944925B2

  公开（公告）日：2018-04-17
• [EN] COMPOSITIONS AND METHODS FOR ACTIVATION AND OVEREXPRESSION OF SECONDARY METABOLITES IN MICROORGANISMS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR L'ACTIVATION ET LA SUREXPRESSION DE MÉTABOLITES SECONDAIRES DANS DES MICROORGANISMES
  申请人：PROSPECTIVE RES INC

  公开号：WO2017139429A1

  公开（公告）日：2017-08-17

  Methods and compositions herein provide non-naturally occurring γ-butyrolactones (GBLs) in racemic mixtures that increase efficiency and effectiveness of screening for production of antibiotics, and enhance yields and express silent pathways. Non-naturally occurring GBLs were synthesized and found to stimulate antibiotic production in several different streptomycete strains. Antibiotic production by Streptomyces coelicolor was induced by a racemic mixture of non-cognate stereoisomers of VB-D, seven of which are non-naturally occurring. Further, novel A-factor-type GBL analogs stimulated antibiotic production in S. coelicolor. Synthesis in response to the treatment with the non-cognates GBL was observed for known compounds including undecylprodigiosin, desferrioxamine and streptorubin B, as was synthesis of a compound of unknown structure. A group of 37 additional microbial strains was screened by principal component analysis to determine optimal concentrations of each of a panel of four non-cognate synthetic GBLs for addition to cultures with optimal stimulation of secondary metabolites, and large scale fermentations were analyzed and product enhancement by the GBLs was observed.