Butyl (S)-2-(2-BENZOYLPHENYLAMINO)-3-[3`-(3-HEPTYL-1-METHYLUREIDO) biphenyl-4-yl] propionate | 692258-39-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Butyl (S)-2-(2-BENZOYLPHENYLAMINO)-3-[3`-(3-HEPTYL-1-METHYLUREIDO) biphenyl-4-yl] propionate
• 英文别名: butyl (S)-2-(2-benzoylphenylamino)-3-[3'-(3-heptyl-1-methylureido)biphenyl-4-yl]propionate；butyl (2S)-2-(2-benzoylanilino)-3-[4-[3-[heptylcarbamoyl(methyl)amino]phenyl]phenyl]propanoate
• CAS: 692258-39-2
• 化学式: C₄₁H₄₉N₃O₄
• 分子量: 647.858
• InChiKey: AMQKCIOIKCHCBU-LHEWISCISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.7
• 重原子数：
  48
• 可旋转键数：
  19
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  87.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (S)-3-[3'-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-[2-(1-phenylmethanoyl)phenylamino]propionic acid 、 正丁醇 在 PS-carbodiimide 作用下， 以 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 为溶剂， 反应 21.0h， 以20%的产率得到Butyl (S)-2-(2-BENZOYLPHENYLAMINO)-3-[3`-(3-HEPTYL-1-METHYLUREIDO) biphenyl-4-yl] propionate
  参考文献：
  名称：

  [EN] BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
  [FR] NOUVEAUX COMPOSES BIAROMATIQUES QUI ACTIVENT LES RECEPTEURS TYPE PPAR DOLLAR G(G), ET LEUR UTILISATION DANS LES COMPOSITIONS COSMETIQUES ET PHARMACEUTIQUES

  摘要：

  公开号：

  WO2004046091A3

文献信息

• Novel biaromatic compounds which activate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Clary Laurence

  公开号：US20050256116A1

  公开（公告）日：2005-11-17

  Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

  具有下列结构式（I）的新型双芳香化合物被用于制备适用于人类或兽医药学（在皮肤科、心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域），或者制备化妆品组合物。
• NOVEL BIAROMATIC COMPOUNDS WHICH ACTIVATE PPARY TYPE RECEPTORS AND COSMETIC/PHARMACEUTICAL COMPOSITIONS COMPRISED THEREOF
  申请人：CLARY LAURENCE

  公开号：US20090062340A1

  公开（公告）日：2009-03-05

  Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

  具有以下结构式（I）的新型双芳香族化合物被制成适合于在人类或兽医学中（在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域中）进行治疗的制药组合物，或者制成化妆品组合物。
• Biaromatic compounds which activate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Galderma Research & Development

  公开号：US07452878B2

  公开（公告）日：2008-11-18

  Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

  具有以下结构式（I）的新型双芳香族化合物制成适用于人类或兽医药学（在皮肤科，以及心血管疾病，免疫疾病和/或与脂质代谢有关的疾病领域），或者制成化妆品组成物。
• BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMMA TYPE RECEPTORS AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
  申请人：GALDERMA RESEARCH & DEVELOPMENT

  公开号：EP1575911B1

  公开（公告）日：2010-01-13
• [EN] BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS<br/>[FR] NOUVEAUX COMPOSES BIAROMATIQUES QUI ACTIVENT LES RECEPTEURS TYPE PPAR DOLLAR G(G), ET LEUR UTILISATION DANS LES COMPOSITIONS COSMETIQUES ET PHARMACEUTIQUES
  申请人：GALDERMA RES & DEV

  公开号：WO2004046091A3

  公开（公告）日：2004-07-29