1-[6-(Cyclopentyloxymethyl)imidazo[1,2-b]pyridazin-2-yl]-3-methylurea | 1191891-38-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-[6-(Cyclopentyloxymethyl)imidazo[1,2-b]pyridazin-2-yl]-3-methylurea
• CAS: 1191891-38-9
• 化学式: C₁₄H₁₉N₅O₂
• 分子量: 289.337
• InChiKey: DBIWRAMKYMOKLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  环戊醇 、 1-[6-(Chloromethyl)imidazo[1,2-b]pyridazin-2-yl]-3-methylurea 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.5h， 以16%的产率得到1-[6-(Cyclopentyloxymethyl)imidazo[1,2-b]pyridazin-2-yl]-3-methylurea
  参考文献：
  名称：

  HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON P13K

  摘要：

  本发明的目的是提供一种化合物或其药用可接受的盐，其抑制PI3K的活性，以调节包括细胞的生长、分化、存活、增殖、迁移、代谢等在内的许多生物过程，因此对于预防/治疗炎症性疾病、动脉硬化、血管/循环疾病、癌症/肿瘤、免疫系统疾病、细胞增殖性疾病、传染性疾病等疾病是有用的。通过提供本说明书中所示的一种取代的2-氨基-5,6-氮杂融合环化合物或其药用可接受的盐来实现这一目标。

  公开号：

  EP2277881A1

文献信息

• HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON PI3K
  申请人：Taniyama Daisuke

  公开号：US20110105457A1

  公开（公告）日：2011-05-05

  The purpose of the present invention is to provide a compound or a pharmaceutically acceptable salt thereof which inhibits the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and is therefore useful for the prevention/treatment of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. This was achieved by providing a substituted 2-amino-5,6-nitrogenated fused ring compound shown in the present specification, or a pharmaceutically acceptable salt thereof.
• HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON P13K
  申请人：Shionogi&Co., Ltd.

  公开号：EP2277881A1

  公开（公告）日：2011-01-26

  The purpose of the present invention is to provide a compound or a pharmaceutically acceptable salt thereof which inhibits the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and is therefore useful for the prevention/treatment of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. This was achieved by providing a substituted 2-amino-5,6-nitrogenated fused ring compound shown in the present specification, or a pharmaceutically acceptable salt thereof.

  本发明的目的是提供一种化合物或其药用可接受的盐，其抑制PI3K的活性，以调节包括细胞的生长、分化、存活、增殖、迁移、代谢等在内的许多生物过程，因此对于预防/治疗炎症性疾病、动脉硬化、血管/循环疾病、癌症/肿瘤、免疫系统疾病、细胞增殖性疾病、传染性疾病等疾病是有用的。通过提供本说明书中所示的一种取代的2-氨基-5,6-氮杂融合环化合物或其药用可接受的盐来实现这一目标。