tri-n-propylsilylacetic acid | 1026121-08-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tri-n-propylsilylacetic acid
• 英文别名: 2-Tripropylsilylacetic acid
• CAS: 1026121-08-3
• 化学式: C₁₁H₂₄O₂Si
• 分子量: 216.396
• InChiKey: NXCDNMMMXPIYRX-UHFFFAOYSA-N

物化性质

• 沸点：
  291.3±23.0 °C(predicted)
• 密度：
  0.899±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.75
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tri-n-propylsilylacetic acid 在 potassium hydroxide 作用下， 以 甲醇 、 乙腈 为溶剂， 以53%的产率得到1,2-bis(tri-n-propylsilyl)ethane
  参考文献：
  名称：

  Electrochemical Synthesis of 1,2-Disilylethanes from α-Silylacetic Acids

  摘要：

  The synthesis of 1,2-disilylethanes [R1R2R3Si-(CH2)(2)SiR1R2R3] is usually conducted by using noble metal reagents or catalysts. This work describes a new electrochemical synthetic method for their preparation in good yields by oxidation of alpha-silylacetic acids at Pt anodes (Kolbe electrolysis). Most of the reported synthesized 1,2-disilylethanes in this work are unknown.

  DOI：

  10.1021/jo200254z
• 作为产物：
  描述：

  三丙基氯硅烷 在 lithium diisopropyl amide 作用下， 反应 4.0h， 生成 tri-n-propylsilylacetic acid
  参考文献：
  名称：

  Electrochemical Synthesis of 1,2-Disilylethanes from α-Silylacetic Acids

  摘要：

  The synthesis of 1,2-disilylethanes [R1R2R3Si-(CH2)(2)SiR1R2R3] is usually conducted by using noble metal reagents or catalysts. This work describes a new electrochemical synthetic method for their preparation in good yields by oxidation of alpha-silylacetic acids at Pt anodes (Kolbe electrolysis). Most of the reported synthesized 1,2-disilylethanes in this work are unknown.

  DOI：

  10.1021/jo200254z

文献信息

• A convenient method for the synthesis of α-silylacetic acids
  作者：Alex V. Shtelman、James Y. Becker

  DOI：10.1016/j.tetlet.2008.03.050

  日期：2008.5

  A method is described for the preparation of alpha-silylacetic acids of the type R(3)SiCH(2)CO(2)H by treating trimethylsilyl acetate with LDA followed by quenching with chlorosilanes. (C) 2008 Elsevier Ltd. All rights reserved.