tert-butyl N-(4-aminobutyl)-N-(3-oxopropyl)dicarbamate | 303178-25-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl N-(4-aminobutyl)-N-(3-oxopropyl)dicarbamate
• 英文别名: tert-butyl N-[4-[(2-methylpropan-2-yl)oxycarbonylamino]butyl]-N-(3-oxopropyl)carbamate
• CAS: 303178-25-8
• 化学式: C₁₇H₃₂N₂O₅
• 分子量: 344.451
• InChiKey: DESWYRPXDOLPSY-UHFFFAOYSA-N

物化性质

• 沸点：
  460.0±38.0 °C(Predicted)
• 密度：
  1.045±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  84.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl N-(4-aminobutyl)-N-(3-oxopropyl)dicarbamate 在 盐酸 、 三乙酰氧基硼氢化钠 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 2.25h， 生成 3β-N-1-[N-(3-[4-aminobutyl])-1,3-diaminopropyldicarbamate]-7α,22-dihydroxy-23,24-bisnor-5α-cholane 22-sulfate trihydrochloride
  参考文献：
  名称：

  Synthesis and antimicrobial activity of squalamine analogue

  摘要：

  Synthesis and antimicrobial activity of squalamine analogue 2 are reported. The synthesis of 2 was accomplished from bisnoralcohol 3. The spermidine moiety was introduced via reductive amination of an appropriately functionalized 3 beta-aminosterol with spermidinyl aldehyde 17 utilizing sodium triacetoxyborohydride as the reducing agent. Compound 2 shows weaker antimicrobial activity than squalamine. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00128-0
• 作为产物：
  描述：

  (4-amino-butyl)-(3-hydroxy-propyl)-carbamic acid tert-butyl ester 在 pyridinium chlorochromate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 tert-butyl N-(4-aminobutyl)-N-(3-oxopropyl)dicarbamate
  参考文献：
  名称：

  Synthesis and antimicrobial activity of squalamine analogue

  摘要：

  Synthesis and antimicrobial activity of squalamine analogue 2 are reported. The synthesis of 2 was accomplished from bisnoralcohol 3. The spermidine moiety was introduced via reductive amination of an appropriately functionalized 3 beta-aminosterol with spermidinyl aldehyde 17 utilizing sodium triacetoxyborohydride as the reducing agent. Compound 2 shows weaker antimicrobial activity than squalamine. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00128-0

文献信息

• Synthesis and DNA damaging ability of enediyne–polyamine conjugates
  作者：Ichiro Suzuki、Akira Shigenaga、Hisao Nemoto、Masayuki Shibuya

  DOI：10.1016/j.tetlet.2003.12.139

  日期：2004.2

  Polyamine-enediyne conjugates were synthesized and exhibited potent DNA damaging ability under physiological conditions. The extent of their activity was shown to depend upon the polyamine length that regulates the DNA binding affinity of the conjugates, and enhanced DNA damaging activities were observed under slightly acidic conditions. (C) 2004 Elsevier Ltd. All rights reserved.
• Synthesis and antimicrobial activity of squalamine analogue
  作者：Hong-Seok Kim、Bo-Seung Choi、Kyung-Chan Kwon、Sang-Ok Lee、Hyun Jung Kwak、Cheol Hae Lee

  DOI：10.1016/s0968-0896(00)00128-0

  日期：2000.8

  Synthesis and antimicrobial activity of squalamine analogue 2 are reported. The synthesis of 2 was accomplished from bisnoralcohol 3. The spermidine moiety was introduced via reductive amination of an appropriately functionalized 3 beta-aminosterol with spermidinyl aldehyde 17 utilizing sodium triacetoxyborohydride as the reducing agent. Compound 2 shows weaker antimicrobial activity than squalamine. (C) 2000 Elsevier Science Ltd. All rights reserved.